Korean J Phys Anthropol.  2007 Dec;20(4):301-309.

Effect of Whole Body Vibration on Trabecular Bone in OVX Rats

Affiliations
  • 1Department of Biomedical Engineering, Yonsei University, Korea. hanskim@yonsei.ac.kr
  • 2Institute of Medical Engineering, Yonsei University, Korea.
  • 3Department of Anatomy, College of Medicine, Konkuk University, Korea.

Abstract

Previous studies showed that whole body vibration could prevent bone resorption and stimulate new bone formation. The aim of this study is to detect and track effect of whole body vibration for osteoporotic bone of OVX rats. 12 Female rats were used and allocated into 5 group, CON, SHAM, WBV 17, WBV 30 and WBV 45. Rats except SHAM group were ovariectomised to induce osteoporosis. Rats in WBV groups were stimulated whole body vibration at magnitude of 1 mm(peak-peak) and frequency 17 Hz, 30 Hz and 45 Hz, repectively, for 8 weeks (20 min, 5 days/week). The 4th lumbar in rats were scanned at a resolution of 35 micrometer at baseline, before stimulation, and 8 weeks by In-vivo Micro-CT. To detect and track changes of morphological characteristics in lumbar trabecuar bone of rats, structural parameters were measured and calculated from acquiring images. In the results, changes of structural characteristics of WBV group were smaller than those of CON group. Loss of quantity of trabecular bone in WBV 45 was the least. In contrast, that in WBV 17 was the biggest. These results showed that reasonable whole body vibration beneficially affected osteoporotic bones. In addition to, whole body vibration was likely to be substituted partly for drug treatment.

Keyword

In-vivo Micro-CT; Osteoporosis; Trabecular bone; Whole body vibration; Morphological characteristics

MeSH Terms

Animals
Bone Resorption
Female
Humans
Osteogenesis
Osteoporosis
Rats*
Vibration*
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