J Korean Soc Coloproctol.  2006 Oct;22(5):346-349.

Sigmoid Colon Cancer with Isolated Metastasis to the Left Kidney

• Kim HJ
• Choi HJ
• Kang WK
• Oh SN
• Jung CK
• Oh ST

Abstract

We report the case of a 63-year-old female with sigmoid colon cancer and isolated metastasis to the left kidney at the time of initial diagnosis. An anterior resection of the sigmoid colon and a left nephrectomy were performed. Three cycles of adjuvant chemotherapy consisting of oxaliplatin, 5-fluorouracil, and leucovorin were given, but two months after the surgery, multiple metastases of the liver were detected on a CT scan. The patient refused further treatment and died 5 months after the discovery of an isolated metastasis. An isolated metastasis to the kidney is very rare in clinical practice. A nephrectomy for kidney metastasis has no effect on survival and quality of life, and a nephrectomy may also compromise the choice of chemotherapy agents that require renal clearance; thus, a careful evaluation of renal function is necessary before a nephrectomy. At present, kidney metastasis should be regarded as an advanced metastatic disease, and aggressive chemotherapy, including target therapy, should prolong survival and improve the quality of life. However, when a synchronous or a metachronous renal tumor is suspected, a nephrectomy should be performed for accurate diagnosis and treatment.

Keyword

Sigmoid colon cancer; Kidney metastasis; Nephrectomy; Synchronous cancer

MeSH Terms

Chemotherapy, Adjuvant
Colon, Sigmoid*
Diagnosis
Drug Therapy
Female
Fluorouracil
Humans
Kidney*
Leucovorin
Liver
Middle Aged
Neoplasm Metastasis*
Nephrectomy
Quality of Life
Sigmoid Neoplasms*
Tomography, X-Ray Computed
Fluorouracil
Leucovorin