Korean J Otorhinolaryngol-Head Neck Surg.  2014 Feb;57(2):124-127. 10.3342/kjorl-hns.2014.57.2.124.

New Treatment for Isolated Invasive Aspergillosis of Sphenoid Sinus in Immunocompetent Subjects: Sphenoid Nasalization Combined with Voriconazole

  • 1Department of Otorhinolaryngology-Head and Neck Surgery, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, Korea.
  • 2Department of Infectious Diseases, Jeju National University Hospital, Jeju National University College of Medicine, Jeju, Korea.
  • 3Department of Otorhinolaryngology-Head and Neck Surgery,Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea. kicubi@nate.com


Isolated invasive fungal sinusitis of sphenoid sinus in a healthy immunocompetent person is extremely rare. Classical treatment of invasive fungal sinusitis is wide sphenoidotomy and surgical debridement combined with antifungal agents, mostly amphotericin B. We describe a case of a 72-year-old immunocompetent woman who presented with deep-seated orbital pain and was diagnosed as isolated invasive aspergillosis in sphenoid sinus invading orbital apex and cavernous sinus. This case was treated successfully with a new combination treatment of sphenoid nasalization and voriconazole, a new antifungal agent. There was no evidence of postoperative recurrence and side effects during the usage of voriconazole.


Invasive aspergillosis; Invasive fungal sinusitis; Sphenoid sinus; Sphenoidotomy; Voriconazole
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