Korean J Clin Microbiol.  2009 Mar;12(1):6-10. 10.5145/KJCM.2009.12.1.6.

T Types, emm Genotypes and Antibiotic Resistance of Streptococcus pyogenes Isolated fromSchool Children in Jinju, 2006

• Koh EH
• Kim IS
• Kim S

• KMID: 1469963
• DOI: http://doi.org/10.5145/KJCM.2009.12.1.6

Abstract

BACKGROUND
Streptococcus pyogenes is the most common cause of bacterial pharyngitis. T antigens and emm genotypes are essential markers for an epidemiological study of S. pyogenes. Macrolide resistance of S. pyogenes is a serious obstracle to successfully treating a sore throat.
METHODS
One-hundred forty-seven strains of S. pyogenes isolated from healthy school children in 2006 were subjected to T typing and emm genotyping. A disk diffusion method was applied for several antibiotics. A double disk diffusion test was performed to evaluate the phenotype distribution of macrolide resistance.
RESULTS
Among T antigens and emm genotypes, T11 (19.7%) and emm78 (16.7%), respectively, were the most common in 2006. Both T5/27/44 (2.3%) and emm44/61 (9.1%) declined to a great extent from about 29% in 2004. The rate of resistance to antibiotics were 11.6% to erythromycin, 4.8% to clindamycin, 21.8% to tetracycline, and 7.5% to ofloxacin. M and cMLSB phenotypes were 52.9% and 41.2% respectively.
CONCLUSION
T typing and emm genotyping proved a dynamic change in their distribution in 2006 compared to the results of 2004. Erythromycin and clindamycin resistance remained low as in 2004, whereas ofloxacin resistance increased slightly. M and cMLSB phenotypes were equivalent in 2006, whereas cMLSB was predominant in 2004.

Keyword

Streptococcus pyogenes; T type; Erythromycin resistance; emm; Sore throat; Pharyngitis

MeSH Terms

Anti-Bacterial Agents
Antigens, Viral, Tumor
Child
Clindamycin
Diffusion
Drug Resistance, Microbial
Epidemiologic Studies
Erythromycin
Genotype
Humans
Ofloxacin
Pharyngitis
Phenotype
Streptococcus
Streptococcus pyogenes
Tetracycline
Anti-Bacterial Agents
Antigens, Viral, Tumor
Clindamycin
Erythromycin
Ofloxacin
Tetracycline