J Korean Endocr Soc.  2009 Dec;24(4):277-280. 10.3803/jkes.2009.24.4.277.

A Case of Prolonged Hypoglycemia Post Topiramate Treatment an Anti-convulsant, in a Type 2 Diabetic Patient

• Lee MJ
• Yom YS
• Lim HW
• Kim ST
• Lee YM
• Cho YZ
• Lee KW
• Kim BJ
• Park KY
• Lim DM

• KMID: 1468548
• DOI: http://doi.org/10.3803/jkes.2009.24.4.277

Abstract

Topiramate is a drug used to treat epilepsy, and is known for its effects including reduced appetite resulting in lower body weight, and the lowering of neutral fat. In addition, topiramate is known to reduce blood sugar levels by increasing insulin sensitivity and by increasing insulin secretion by glucose stimulation. The authors report a case of persistent hypoglycemia, in a patient who had been administrating topiramate, as a treatment for epilepsy following an episode of cerebral infarction.

Keyword

diabetes mellitus; hypoglycemia; topiramate

MeSH Terms

Appetite
Blood Glucose
Body Weight
Cerebral Infarction
Diabetes Mellitus
Epilepsy
Fructose
Glucose
Humans
Hypoglycemia
Insulin
Insulin Resistance
Blood Glucose
Fructose
Glucose
Insulin

Figure

• 

  Fig. 1 Pancreatic dynamic CT shows about 2.8 × 2.0 cm-sized, lobulating contoured cystic mass with thin wall, but no enhancing solid portion in pancreatic head (white arrow). There is no associated pancreatic duct dilatation, pancreatic parenchymal swelling, or peripancreatic fluid collection.

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