Res Vestib Sci.
2009 Dec;8(2):161-163.
Downbeat, Gaze-evoked and Perverted Head-shaking Nystagmus Associated with Dapsone Toxicity
- Affiliations
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- 1Department of Neurology, Chonbuk National University College of Medicine, Jeonju, Korea. ohsun@chonbuk.ac.kr
Abstract
- Dapsone is an agent commonly used to treat leprosy and its most common adverse effect is a hemolytic anemia. We present a patient who showed transient downbeat, bilateral horizontal gaze-evoked nystagmus (GEN), and perverted head-shaking nystagmus after taking a large dose of dapsone. These oculomotor abnormalities are assumed to be a reversible vestibulocerebellar dysfunction caused by over-dose of dapsone.
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