J Clin Neurol.  2006 Dec;2(4):283-285. 10.3988/jcn.2006.2.4.283.

Downbeat, Positional, and Perverted Head-Shaking Nystagmus Associated with Lamotrigine Toxicity

• Oh SY
• Kim JS
• Lee YH
• Lee AY
• Kim J
• Kim JM

• KMID: 1980472
• DOI: http://doi.org/10.3988/jcn.2006.2.4.283

Abstract

Lamotrigine is an effective antiepileptic drug with few adverse effects. Nystagmus is one of the commonly observable signs of lamotrigine overdose, which may result from central nervous system involvement. However, the physiologic basis of lamotrigine-induced nystagmus is not fully understood. Here we report a patient who presented with lamotrigine-associated nystagmus that was probably related to cerebellar dysfunction.

Keyword

Lamotrigine toxicity; Downbeat nystagmus; Perverted head-shaking nystagmus

MeSH Terms

Central Nervous System
Cerebellar Diseases
Humans

Figure

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  Figure 1 Brain MRI scan showing no evidence of Arnold-Chiari malformation or a discrete lesion in the nodulus or flocculus.

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