Int J Oral Biol.  2010 Dec;35(4):203-207.

Inhibitory Effect of Pentose on Biofilm Formation by Oral Bacteria

  • 1Department of Oral Microbiology and Immunology, College of Dentistry, Dankook University, Anseo-Dong, Dongnam-Gu, Cheonan, Choongnam, 330-714, Korea.


A number of bacterial species coexist in oral cavities as a biofilm rather than a planktonic arrangement. By forming an oral biofilm with quorum sensing properties, microorganisms can develop a higher pathogenic potential and stronger resistance to the host immune system and antibiotics. Hence, the inhibition of biofilm formation has become a major research issue for the future prevention and treatment of oral diseases. In this study, we investigated the effects of pentose on biofilm formation and phenotypic changes using wild type oral bacteria obtained from healthy human saliva. D-ribose and D-arabinose were found to inhibit biofilm formation, but have no effects on the growth of each oral bacterium tested. Pentoses may thus be good candidate biofilm inhibitors without growth-inhibition activity and be employed for the future prevention or treatment of oral diseases.


biofilm; quorum sensing; pentose; D-ribose; D-arabinose
Full Text Links
  • IJOB
export Copy
  • Twitter
  • Facebook
Similar articles
Copyright © 2021 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: