Int J Oral Biol.  2018 Dec;43(4):171-175. 10.11620/IJOB.2018.43.4.171.

Quorum Sensing Regulation of Biofilm Formation by Periodontal Pathogens

Affiliations
  • 1Department of Oral Microbiology and Immunology, School of Dentistry, Seoul National University, Seoul 03080, Republic of Korea. bongchoi@snu.ac.kr

Abstract

Quorum sensing (QS) is a cell density-dependent communication mechanism between bacteria through small signaling molecules. When the number of QS signaling molecules reaches a threshold, they are transported back into the cells or recognized by membrane-bound receptors, triggering gene expression which affects various phenotypes including bioluminescence, virulence, adhesion, and biofilm formation. These phenotypes are beneficial for bacterial survival in harsh environments. This review summarizes the application of QS inhibitors for control of biofilm formation and virulence expression of periodontal pathogens.

Keyword

Periodontitis; Subgingival biofilm; F. nucleatum AI-2; QS Inhibitors

MeSH Terms

Bacteria
Biofilms*
Gene Expression
Periodontitis
Phenotype
Quorum Sensing*
Virulence
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