Clin Pediatr Hematol Oncol.
2011 Oct;18(2):140-143.
A Case of Secondary Precursor B-cell Acute Lymphoblastic Leukemia Occurring after Treatment of Hemophagocytic Lymphohistiocytosis
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- 1Department of Pediatrics, Graduate School of Medicine, Gachon University of Medicine and Science, Incheon, Korea. isjeon@gilhospital.com
Abstract
- Hemophagocytic lymphohistiocytosis (HLH), although uncommon, is illustrated as a dramatic clinical presentation of multi-systemic inflammation due to the impaired activity of cytotoxic T-cell and NK cell. Etoposide, an important component of the HLH treatment, is thought to have a leukemogenic potential. Furthermore, it has been suggested that the underlying immunologic dysfunction in HLH might be involved in the occurrence of secondary leukemia. Only a few cases of secondary ALLs after HLH have been reported. We report herein a case of secondary precursor B-cell ALL which occurred after the treatment of HLH.
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