Anat Cell Biol.
2011 Dec;44(4):245-255. 10.5115/acb.2011.44.4.245.
Induced pluripotent stem cells and personalized medicine: current progress and future perspectives
- Affiliations
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- 1Department of Surgery, Gachon University Gil Hospital, Incheon, Korea. chunysmd@gmail.com
- 2Department of Anatomy and Cell Biology, Gachon University, Incheon, Korea.
- 3Center for Regenerative Medicine, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Korea.
- KMID: 1447438
- DOI: http://doi.org/10.5115/acb.2011.44.4.245
Abstract
- Generation of induced pluripotent stem cells (iPSCs) has revolutionized the field of regenerative medicine by providing researchers with a unique tool to derive disease-specific stem cells for study. iPSCs can self-renew and can differentiate into many cell types, offering a potentially unlimited source of cells for targeted differentiation into somatic effector cells. Hence, iPSCs are likely to be invaluable for therapeutic applications and disease-related research. In this review, we summarize the recent progress of iPSC generation that has been made with an emphasis on both basic and clinical applications including disease modeling, drug toxicity screening/drug discovery and cell replacement therapy.
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