- Genetic Architecture of Circulating Very-Long-Chain (C24:0 and C22:0) Ceramide Concentrations
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Cresci S, Zhang R, Yang Q, Duncan MS, Xanthakis , Jiang X, Vasan RS, Schaffer J, Peterson L
- KMID: 2470809
- J Lipid Atheroscler.
- 2020 Jan;9(1):172-183.
- doi: 10.12997/jla.2020.9.1.172
OBJECTIVE: Total ceramide concentrations are linked with increased insulin resistance and cardiac dysfunction. However, recent studies have demonstrated that plasma concentrations of specific very-long-chain fatty ceramides (C24:0 and C22:0) are... -
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- Complete genome sequence of a methicillin-resistant Staphylococcus schleiferi strain from canine otitis externa in Korea
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Lee GY, Yang SJ
- KMID: 2469026
- J Vet Sci.
- 2020 Jan;21(1):e11.
- doi: 10.4142/jvs.2020.21.e11
The increase in canine skin and soft tissue infections, such as pyoderma and otitis, caused by Staphylococcus schleiferi strains, is of significant zoonotic concern. In this study, we report the... -
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- Review of statistical methods for survival analysis using genomic data
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Lee S, Lim H
- KMID: 2468867
- Genomics Inform.
- 2019 Dec;17(4):e41.
- doi: 10.5808/GI.2019.17.4.e41
Survival analysis mainly deals with the time to event, including death, onset of disease, and bankruptcy. The common characteristic of survival analysis is that it contains “censored†data, in which... -
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- DNA methylation: a cause and consequence of type 2 diabetes
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Kim M
- KMID: 2468864
- Genomics Inform.
- 2019 Dec;17(4):e38.
- doi: 10.5808/GI.2019.17.4.e38
DNA methylation is a relatively stable epigenetic modification that can regulate and stabilize gene expression patterns and hence establish cell identity. Because metabolic intermediates are key factors of DNA methylation... -
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- Molecular Genetics of von Willebrand Disease in Korean Patients: Novel Variants and Limited Diagnostic Utility of Multiplex Ligation-Dependent Probe Amplification Analyses
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Kim HJ, Kim SK, Yoo KY, Lee KO, Yun JW, Kim SH, Kim HJ, Park SK
- KMID: 2450949
- Ann Lab Med.
- 2019 Nov;39(6):545-551.
- doi: 10.3343/alm.2019.39.6.545
BACKGROUND: von Willebrand disease (VWD), characterized by quantitative or qualitative defects of von Willebrand factor (VWF), is the most common inheritable bleeding disorder. Data regarding the genetic background of VWD... -
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- Trends in Genomics & Informatics: a statistical review of publications from 2003 to 2018 focusing on the most-studied genes and document clusters
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Kim JH, Nam HJ, Park HS
- KMID: 2462039
- Genomics Inform.
- 2019 Sep;17(3):e25.
- doi: 10.5808/GI.2019.17.3.e25
Genomics & Informatics (NLM title abbreviation: Genomics Inform) is the official journal of the Korea Genome Organization. Herein, we conduct a statistical analysis of the publications of Genomics & Informatics... -
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- The interaction between gut microbiome and nutrients on development of human disease through epigenetic mechanisms
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Lee HS
- KMID: 2462038
- Genomics Inform.
- 2019 Sep;17(3):e24.
- doi: 10.5808/GI.2019.17.3.e24
Early environmental exposure is recognized as a key factor for long-term health based on the Developmental Origins of Health and Disease hypothesis. It considers that early-life nutrition is now being... -
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- Current status and future direction of digital health in Korea
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Shin SY
- KMID: 2455807
- Korean J Physiol Pharmacol.
- 2019 Sep;23(5):311-315.
- doi: 10.4196/kjpp.2019.23.5.311
Recently, digital health has gained the attention of physicians, patients, and healthcare industries. Digital health, a broad umbrella term, can be defined as an emerging health area that uses brand... -
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- Challenges and Considerations in Sequence Variant Interpretation for Mendelian Disorders
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Kim YE, Ki CS, Jang MA
- KMID: 2450964
- Ann Lab Med.
- 2019 Sep;39(5):421-429.
- doi: 10.3343/alm.2019.39.5.421
In 2015, the American College of Medical Genetics and Genomics (ACMG), together with the Association for Molecular Pathology (AMP), published the latest guidelines for the interpretation of sequence variants, which... -
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- Fungal Genomics in Dermatology
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Lee YB, Lee SY, Seo JM, Kang MJ, Yu DS
- KMID: 2462934
- Korean J Med Mycol.
- 2019 Jun;24(2):37-44.
- doi: 10.17966/JMI.2019.24.2.37
To date, hundreds of fungal genomes have been sequenced, and many more are underway. Recently developed cutting-edge techniques generate very large amounts of data, and the field of fungal genomics... -
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- Antifungal Mechanism of Action of Lauryl Betaine Against Skin-Associated Fungus Malassezia restricta
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Do E, Lee HG, Park M, Cho YJ, Kim DH, Park SH, Eun D, Park T, An S, Jung WH
- KMID: 2455704
- Mycobiology.
- 2019 Jun;47(2):242-249.
- doi: 10.1080/12298093.2019.1625175
Betaine derivatives are considered major ingredients of shampoos and are commonly used as antistatic and viscosity-increasing agents. Several studies have also suggested that betaine derivatives can be used as antimicrobial... -
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- Oral Metagenomic Analysis Techniques
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Chung SK
- KMID: 2451786
- J Dent Hyg Sci.
- 2019 Jun;19(2):86-95.
- doi: 10.17135/jdhs.2019.19.2.86
The modern era of microbial genome analysis began in earnest in the 2000s with the generalization of metagenomics and gene sequencing techniques. Studying complex microbial community such as oral cavity... -
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- Methylation Signature for Prediction of Progression Free Survival in Surgically Treated Clear Cell Renal Cell Carcinoma
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Kang HW, Park H, Seo SP, Byun YJ, Piao XM, Kim SM, Kim WT, Yun SJ, Jang W, Shon HS, Ryu KH, Lee SC, Kim WJ, Kim YJ
- KMID: 2445802
- J Korean Med Sci.
- 2019 May;34(19):e144.
- doi: 10.3346/jkms.2019.34.e144
BACKGROUND: Little is known about epigenetic silencing of genes by promoter hypermethylation in renal cell carcinoma (RCC). The aim of this study was to identify prognostic methylation markers in surgically... -
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- Essential Elements for Establishing Clinical Next-generation Sequencing Testing
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Park KJ, Lee W, Chun S, Min WK
- KMID: 2441822
- Lab Med Online.
- 2019 Apr;9(2):37-44.
- doi: 10.3343/lmo.2019.9.2.37
Over the past decade, next-generation sequencing (NGS) has evolved at an astonishing pace and has revolutionized clinical medicine as well as genomics research. The rapid advancements in NGS technologies have... -
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- An Enzymolysis-Assisted Agrobacterium tumefaciens-Mediated Transformation Method for the Yeast-Like Cells of Tremella fuciformis
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Wang Y, Xu D, Sun X, Zheng L, Chen L, Ma A
- KMID: 2455600
- Mycobiology.
- 2019 Mar;47(1):59-65.
- doi: 10.1080/12298093.2018.1559121
Agrobacterium tumefaciens-mediated transformation (ATMT), as a simple and versatile method, achieves successful transformation in the yeast-like cells (YLCs) of Tremella fuciformis with lower efficiency. Establishment of a more efficient transformation... -
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- Enrichment of rare alleles within epigenetic chromatin marks in the first intron
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Jo SS, Choi SS
- KMID: 2447799
- Genomics Inform.
- 2019 Mar;17(1):e9.
- doi: 10.5808/GI.2019.17.1.e9
In previous studies, we demonstrated that some sites in the first intron likely regulate gene expression. In the present work, we sought to further confirm the functional relevance of first... -
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- Statistical Analysis of Metagenomics Data
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Calle ML
- KMID: 2447796
- Genomics Inform.
- 2019 Mar;17(1):e6.
- doi: 10.5808/GI.2019.17.1.e6
Understanding the role of the microbiome in human health and how it can be modulated is becoming increasingly relevant for preventive medicine and for the medical management of chronic diseases.... -
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- In this issue, there are 10 articles: two review articles, six original articles, one clinical genomics, and one application note
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Park T
- KMID: 2447791
- Genomics Inform.
- 2019 Mar;17(1):e1.
- doi: 10.5808/GI.2019.17.1.e1
No abstract available. -
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- Radiomics and radiogenomics of primary liver cancers
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Jeong WK, Jamshidi N, Felker ER, Raman SS, Lu DS
- KMID: 2447246
- Clin Mol Hepatol.
- 2019 Mar;25(1):21-29.
- doi: 10.3350/cmh.2018.1007
Concurrent advancements in imaging and genomic biomarkers have created opportunities to identify non-invasive imaging surrogates of molecular phenotypes. In order to develop such imaging surrogates radiomics and radiogenomics/imaging genomics will... -
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- Imaging Informatics: A New Horizon for Radiology in the Era of Artificial Intelligence, Big Data, and Data Science
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Kim JH
- KMID: 2442512
- J Korean Soc Radiol.
- 2019 Mar;80(2):176-201.
- doi: 10.3348/jksr.2019.80.2.176
We are witnessing the big wave of Industrial Revolution 4.0, enabled by artificial intelligence (AI) and big data, which has shaken the entire industry and day-to-day life as well as... -
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