J Korean Soc Radiol.  2011 Jan;64(1):91-95. 10.3348/jksr.2011.64.1.91.

KIT-negative Gastrointestinal Stromal Tumor in a Child: A Case Report

• Lim SW
• Lee YH
• Park SH
• Choi DY
• Choi GH

• KMID: 1443589
• DOI: http://doi.org/10.3348/jksr.2011.64.1.91

Abstract

We report here on the imaging findings of the case of KIT-negative gastrointestinal stromal tumor (GIST) in the stomach of a 12-year-old girl. Radiologic studies revealed the presence of a huge exophytic growing mass that originated from the gastric wall and this mass consisted of solid and cystic components on USG, CT and MR. The cystic regions were mainly located at the periphery of the mass and they were revealed to be myxoid degeneration and hemorrhage on histopathologic examination. The tumor consisted of epithelioid and typical spindle cells and they showed negative immunoreactivity for KIT. Although KIT-negative GISTs are rare, they can be considered in the differential diagnosis when a large heterogeneous extraluminal mass that contains solid portions and various degrees of peripheral cystic regions is observed.

MeSH Terms

Child
Diagnosis, Differential
Gastrointestinal Stromal Tumors
Hemorrhage
Humans
Stomach

Figure

• 

  Fig. 1 A 12-year-old girl presented with a KIT-negative gastrointestinal stromal tumor of the stomach. A. Abdominal ultrasonography shows a huge mass with heterogenous echogenicity and the mass is composed of cystic and solid regions. B, C. Axial pre- and post- contrast CT images show a huge mass (arrows) occupying the abdominal cavity. The mass shows enhancing solid and non-enhancing cystic components. D. Coronal contrast-enhanced CT image shows a heterogeneously enhanced exophytic mass (arrow) originating from the gastric wall of the lower body (asterisk). E-G. Axial T1-weighted MR image (E), T2-weighted MR image (F) and contrast-enhanced T1-weighted MR image (G) show a complex mass with cystic and solid regions. The solid regions (asterisk) have intermediate signal intensity on both the T1- and T2-weighted images with slight contrast enhancement on the contrast-enhanced T1-weighted image. The cystic regions (arrow) show low signal intensity on the T1-weighted image and high signal intensity on the T2-weighted image without contrast enhancement on the contrast-enhanced T1-weighted image. H. Photograph of gross pathologic specimen revealed that the tumor had cystic regions that showed myxoid degeneration (arrow) and hemorrhage (asterisk).

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