J Bacteriol Virol.  2012 Sep;42(3):181-188. 10.4167/jbv.2012.42.3.181.

Staphylococcus aureus Membrane Vesicles and Its Potential Role in Bacterial Pathogenesis

• Lee JC

• KMID: 1434746
• DOI: http://doi.org/10.4167/jbv.2012.42.3.181

Abstract

The production of extracellular vesicles is a ubiquitous process in both Gram-negative and Gram-positive bacteria. Gram-negative bacteria produce and secrete outer membrane vesicles during in vitro culture and in vivo infection and their contribution to bacterial pathogenesis has been well characterized. However, little is known about extracellular vesicles in Gram-positive bacteria. Until now, only few Gram-positive bacterial species, Staphylococcus aureus, Bacillus anthracis, B. cereus, and B. subtilis, have been found to produce membrane vesicles (MVs), but their contribution to bacterial pathogenesis has not been understood. Here, I discuss S. aureus MVs in terms of MV production, interaction of MVs with host cells, and immune response against MVs to understand its potential role in S. aureus pathogenesis.

Keyword

Membrane vesicles; Bacterial pathogenesis; Virulence determinants; Proteomes

MeSH Terms

Bacillus anthracis
Gram-Negative Bacteria
Gram-Positive Bacteria
Membranes
Proteome
Staphylococcus
Staphylococcus aureus
Proteome

Figure

• 

  Figure 1 Membrane vesicle production in S. aureus. (A). Transmission electron micrograph (TEM) of MVs prepared from S. aureus ATCC 25923 cultured in Luria-Bertani broth. (B) Production and secretion of MVs from S. aureus 06ST1048 during in vivo infection. Mice were infected with S. aureus 06ST1048 intratracheally for 18 h. The infected lung tissues were prepared for TEM analysis. Arrows indicate MVs produced by S. aureus.

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