J Korean Med Sci.  2000 Jun;15(3):337-342. 10.3346/jkms.2000.15.3.337.

Congenital cytomegalovirus infection: three autopsy case reports

• Ko HM
• Kim KS
• Park JW
• Lee YJ
• Lee MY
• Lee MC
• Park CS
• Juhng SW
• Choi C

• KMID: 1128634
• DOI: http://doi.org/10.3346/jkms.2000.15.3.337

Abstract

We report three autopsy cases of congenital cytomegalovirus (CMV) infection in fetuses with a review of literature. The clinical manifestations in these cases of congenital CMV infection include intrauterine fetal death, hydrops fetalis, and CMV pneumonia associated with cardiovascular defect. The pathological characteristics were as follows: 1) the kidney was the most frequently involved organ, followed by lung and liver, 2) CMV inclusions were found predominantly in epithelial cells and to a lesser degree in endothelial cells, 3) intrahepatic bile duct epithelial cells were frequently involved, and 4) inflammatory reaction around CMV inclusions was not prominent in the early stage of pregnancy. Diagnostic confirmation was obtained by in situ hybridization (ISH) using a biotinylated CMV-DNA probe, which demonstrated intranuclear inclusions and sometimes recognized cells that did not show intranuclear inclusion.

Keyword

Autopsy; Cytomegalovirus; Inclusion Bodies; In situ Hybridzation

MeSH Terms

Autopsy
Case Report
Cytomegalovirus Infections/virology
Cytomegalovirus Infections/pathology*
Cytomegalovirus Infections/congenital*
Female
Fetal Diseases
Human
Male
Pregnancy
Pregnancy Complications, Infectious