Yonsei Med J.  1991 Mar;32(1):16-23. 10.3349/ymj.1991.32.1.16.

Effects of iodinated fatty acid ester on human hepatocellular carcinoma cells

• Kim H
• Park C
• Lee YB
• Yoo HS
• Park JH
• Lee WY

• KMID: 1117732
• DOI: http://doi.org/10.3349/ymj.1991.32.1.16

Abstract

The interaction between Lipiodol and cells was studied by treating Lipiodol in a human hepatocellular carcinoma cell line(Hep) and mouse fibroblast cell line (L929). Irregular, sustained radioactivity was released from both cell lines shortly after incubation in the radioiodinated Lipiodol mixed media. Lipiodol droplets were found to be firmly attached to the cells following the incubation and these cells were strongly positive for fat stains. The radioiodinated Lipiodol demonstrated the same behavior of accumulation within the cell and on the cell membrane. Although the amount of Lipiodol attached was almost equal in both of the cell lines, the final amount accumulated in the cells was larger in the Hep cells. The accumulation of Lipiodol within the cell and on the cell membrane may play a significant role for its selective targeting and its prolonged retention in the solid tumor.

Keyword

Lipiodol; I-131-Lipiodol; hepatocellular carcinoma

MeSH Terms

Carcinoma, Hepatocellular/*pathology/therapy
Human
Iodine Radioisotopes/diagnostic use/therapeutic use
Iodized Oil/pharmacokinetics/*pharmacology/therapeutic use
Liver Neoplasms/*pathology/therapy
Support, Non-U.S. Gov't
Tumor Cells, Cultured/drug effects