Korean J Gastroenterol.  2006 Jan;47(1):59-64.

A Case of Cronkhite-Canada Syndrome Showing Resolution with Helicobactor pylori Eradication and Omeprazole

• Kim MS
• Jung HK
• Jung HS
• Choi JY
• Na YJ
• Pyun GW
• Ryu JH
• Moon IH
• Jo MS

Abstract

We describe a 58-year-old woman who was incidentally found to have gastric and colonic polyposis, hypoalbuminemia, cutaneous hyperpigmentation and onychodystrophy (Cronkhite-Canada syndrome). Histology of polyps from the stomach showed features of juvenile or retention type (hamartomatous) polyps with Helicobacter pylori (H. pylori) infection. The large pedunculated colonic polyps showed hamartomatous polyps with adenomatous component and polypectomy was performed. After the treatment with H. pylori eradication and omeprazole, the gastric polyposis, hypoalbuminemia and anemia regressed, and endoscopic polypectomy of gastric polyps were performed. After the continuous use of omeprazole for 14 months, the patient showed complete resolution of clinical features of Cronkhite-Canada syndome. The experience of this case suggests that eradication of H. pylori and proton pump inhibitor treatment might be considered in patients with gastric polyposis combined with Cronkhite-Canada syndome.

Keyword

Cronkhite-Canada syndrome; Helicobacter pylori; Omeprazole

MeSH Terms

Anti-Ulcer Agents/*therapeutic use
Colonic Polyps/complications/microbiology/pathology
Female
Helicobacter Infections/complications/*drug therapy
*Helicobacter pylori
Humans
Hyperpigmentation/pathology
Middle Aged
Nails, Malformed/pathology
Omeprazole/*therapeutic use
Polyps/*complications/microbiology/pathology
Proton Pumps/antagonists & inhibitors
Stomach Neoplasms/*complications/microbiology/pathology
Syndrome