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Hepatokines as a Link between Obesity and Cardiovascular Diseases

Yoo HJ, Choi KM

Non-alcoholic fatty liver disease, which is considered a hepatic manifestation of metabolic syndrome, independently increases the risks of developing cardiovascular disease (CVD) and type 2 diabetes mellitus. Recent emerging evidence...
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Mechanism of Lipid Induced Insulin Resistance: An Overview

Bhattacharya S, Kundu R, Dasgupta S, Bhattacharya S

Type 2 diabetes (T2D) is rapidly spreading throughout the world. It's an insidious disease and still treated in an indirect manner without having specific drug target. In majority cases T2D...
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Evaluation of Arterial Stiffness in Patients with Behçet's Disease by Using Noninvasive Radiological Methods such as Intima-Media Thickness of the Carotid, Ankle-Brachial Pressure Index, Coronary Artery Calcium Scoring, and Their Relation to Serum Fetuin-A Levels: A Case-Control Study

Uyar B, Solak A, Genc B, Akyildiz M, Sahin N, Uyar IS, Saklamaz A

BACKGROUND: Behcet's disease (BD) is a chronic, recurrent inflammatory systemic vasculitis. Evidence for increased atherosclerosis in BD has been observed. The relation between cardiovascular risk factors and increased atherosclerosis in...
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Coronary artery calcification and serum markers

Kim SB

  • KMID: 2256405
  • Korean J Med.
  • 2007 May;72(5):443-445.
Coronary artery calcification is associated with the increased cardiovascular mortality and the extent of atheromatous plaque, especially in the hemodialysis patients. Vascular calcification was in the past considered a passive...
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Discovery of the serum biomarker proteins in severe preeclampsia by proteomic analysis

Park J, Cha DH, Lee SJ, Kim YN, Kim YH, Kim KP

Preeclapsia (PE) is a severe disorder that occurs during pregnancy, leading to maternal and fetal morbidity and mortality. PE affects about 3-8% of all pregnancies. In this study, we conducted...
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Nicotinamide riboside regulates inflammation and mitochondrial markers in AML12 hepatocytes

Lee HJ, Yang SJ

BACKGROUND/OBJECTIVES: The NAD+ precursor nicotinamide riboside (NR) is a type of vitamin B3 found in cow's milk and yeast-containing food products such as beer. Recent studies suggested that NR prevents...
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Associations of serum fetuin-A and oxidative stress parameters with polycystic ovary syndrome

Sak S, Uyanikoglu H, Incebiyik , Incebiyik , Hilali NG, Sabuncu T, Sak E

OBJECTIVE: The aim of this study was to compare serum fetuin-A levels and oxidative stress markers, as indicators of insulin resistance, in women with polycystic ovary syndrome (PCOS) and in...
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Serum osteoprotegerin and fetuin-A level is associated with coronary artery calcification score in the patients with end-stage renal disease

Kim SW, Jung HH, Han H

  • KMID: 2256407
  • Korean J Med.
  • 2007 May;72(5):451-458.
BACKGROUND: Coronary artery calcification is frequently seen in hemodialysis patients. The development and progression of coronary artery calcification is similar to osteogenesis, and a naturally occurring serum inhibitor of calcification...
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Plasma Fetuin-A Levels and Risk of Type 2 Diabetes Mellitus in A Chinese Population: A Nested Case-Control Study

Wang Y, Koh WP, Jensen MK, Yuan JM, Pan A

BACKGROUND: Fetuin-A is a hepatokine that involved in the pathogenesis of insulin resistance. Previous epidemiological studies have found a positive association between blood fetuin-A and type 2 diabetes mellitus (T2DM)...
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Association between Healthy Eating Index-2010 and Fetuin-A Levels in Patients with Type 2 Diabetes: a Case-Control Study

Roshanzamir F, Miraghajani M, Mansourian M, Ghiasvand , Safavi SM

The Healthy Eating Index-2010 (HEI-2010) assesses compliance with the 2010 Dietary Guidelines for Americans. Studies suggest that adherence to the HEI-2010 is related to lower the risk of type 2...
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A Low Intact PTH Is Associated with Simple Vascular Calcifications in Hemodialysis Patients

Oh SW, Kim SC, Cha JJ, Kim HW, Yang HN, Kim MG, Jo SK, Cho WY, Kim HK

  • KMID: 2080180
  • Korean J Nephrol.
  • 2011 May;30(3):260-268.
PURPOSE: Cardiovascular diseases are a common cause of mortality in patients with end stage renal disease and are associated with vascular calcification (VC) and arterial stiffness. In addition to high...
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Serum Visfatin and Fetuin-A Levels and Glycemic Control in Patients with Obese Type 2 Diabetes Mellitus

Gunduz FO, Yildirmak , Temizel M, Faki Y, Cakmak M, Durmuscan , Sezgin F

BACKGROUND: Visfatin is an adipokine produced by visceral adipose tissue and has insulin-mimicking effects. Fetuin-A is a hepatic secretory protein that binds the insulin receptor and inhibits insulin action both...
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Left ventricular dysfunction in relation with systemic inflammation in chronic obstructive pulmonary disease patients

Gulen ST, Eryilmaz U, Yilmaz M, Karadag F

BACKGROUND/AIMS: Most important cause of mortality in chronic obstructive pulmonary disease (COPD) patients is known to be cardiovascular disease (CVD). The objective of the present study was to evaluate the...
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Serum osteoprotegerin is associated with vascular stiffness and the onset of new cardiovascular events in hemodialysis patients

Lee JE, Kim HJ, Moon SJ, Nam JS, Kim JK, Kim SK, Yun GY, Ha SK, Park HC

BACKGROUND/AIMS: Osteoprotegerin (OPG) and fetuin-A are vascular calcification regulators that may be related to high cardiovascular (CV) mortality in hemodialysis (HD) patients. We evaluated the relationship between OPG, fetuin-A, and...
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Exendin-4 Inhibits the Expression of SEPP1 and Fetuin-A via Improvement of Palmitic Acid-Induced Endoplasmic Reticulum Stress by AMPK

Lee J, Hong SW, Park SE, Rhee EJ, Park CY, Oh KW, Park SW, Lee WY

BACKGROUND: Selenoprotein P (SEPP1) and fetuin-A, both circulating liver-derived glycoproteins, are novel biomarkers for insulin resistance and nonalcoholic fatty liver disease. However, the effect of exendin-4 (Ex-4), a glucagon-like peptide-1...
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Effects of Lowering Dialysate Calcium Concentrations on Arterial Stiffness in Patients Undergoing Hemodialysis

Kim JK, Moon SJ, Park HC, Lee JS, Sim SR, Bae SC, Ha SK

BACKGROUND/AIMS: We assessed changes in hemodynamic and arterial stiffness parameters following reductions of dialysate calcium concentrations in patients undergoing hemodialysis. METHODS: In this prospective study, 20 patients on maintenance hemodialysis (10...
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