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L-plastin: Structure, Regulation, and Roles in Cancer Invasion and in Macrophages

Kim HJ, Lee HH

The cytoskeleton consists of 3 filamentous components: intermediate filaments, microtubules, and actin filaments. Actin filaments continuously assemble and disassemble far out of equilibrium to adapt cells in response to external...
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Localization of cytoskeletal proteins in Cryptosporidium parvum using double immunogold labeling

Yu JR, Lee SH

Actin and some actin binding proteins such as tropomyosin, -actinin and troponin T were localized by simultaneous double immunogold labeling in several developmental stages of Cryptosporidium parvum. All of the...
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Staurosporine and cytochalasin D induce chondrogenesis by regulation of actin dynamics in different way

Kim M, Song K, Jin EJ, Sonn J

  • KMID: 1389731
  • Exp Mol Med.
  • 2012 Sep;44(9):521-528.
Actin cytoskeleton has been known to control and/or be associated with chondrogenesis. Staurosporine and cytochalasin D modulate actin cytoskeleton and affect chondrogenesis. However, the underlying mechanisms for actin dynamics regulation...
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Distribution of actin and tropomyosin in Cryptosporidium muris

Yu JR

Actin and tropomyosin of Cryptosporidium muris were localized by immunogold labeling. Two kinds of antibodies for actin labeling were used. The polyclonal antibody to skeletal muscle (chicken back muscle)...
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Localization of actin and myosin in Cryptosporidium parvum using immunogold staining

Yu JR, Chai JY

The location of actin and myosin of the several stages of Cryptosporidium parvum was observed. The tissue antigen of C. parvum was prepared through immunosuppression of ICR mice with Depomedrol....
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Change of alpha-SM Actin Expression Induced by the Antibody for TGF-beta in Fibroblast NIH3T3 Culture: The basic research for the inhibition of wound contracture

Lee BH, Kang HK, Kim JJ, Kim DK, Yoon DW

  • KMID: 1835259
  • J Korean Soc Coloproctol.
  • 2001 Jun;17(3):113-118.
PURPOSE: The purpose of this experiment is to measure the expression of TGF-beta and alpha-SM actin (smooth muscle actin) from fibroblast culture by the duration of culture days and to...
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Propofol Decreases Cell Volume and Intracellular Calcium, and Rearranges Actin Filaments in Astroglial Cells

Kim MH, Yang MK

BACKGROUND: Regulation of cell volume is one of the major physiologic functions in living cells. Intracellular calcium ion and cytoskeletal component of cell membrane play pivotal roles in cell volume...
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Cytotoxicological Effect of Tebufenozide, an Insect Growth Regulator (IGR) : Stimulation of Filamentous Actin Reorganization and Enhancement of Hsp27 Expression in Drosophila Kc Cells

Hwang JN, Jung HJ, Seo YR

  • KMID: 1611499
  • Korean J Physiol Pharmacol.
  • 2004 Dec;8(6):351-354.
The cytotoxicological responses to insect growth regulator (IGR), using tebufenozide as ecdysteroid mimic, were investigated in Drosophila Kc cells. Treatment of Kc cells with tebufenozide showed significant growth inhibition and...
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Actin Engine in Immunological Synapse

Piragyte I, Jun CD

T cell activation and function require physical contact with antigen presenting cells at a specialized junctional structure known as the immunological synapse. Once formed, the immunological synapse leads to sustained...
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Endothelial F-actin changes in the alkali burned rabbit cornea

Kim EK, Kim HB, Chung YT, Kim IC

The healing mechanism of corneal endothelium after alkali burn was not completely understood. Rabbit cornea was burned with 1N sodium hydxoside for 1 minute. Endothelial F-actin was stained with NBD-phallacidin...
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Molecular and biochemical characterization of a novel actin bundling protein in Acanthamoeba

Alafag JI, Moon EK, Hong YC, Chung DI, Kong HH

Actin binding proteins play key roles in cell structure and movement particularly as regulators of the assembly, stability and localization of actin filaments in the cytoplasm. In the present study,...
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Odontogenic Ameloblast-Associated Protein (Odam) Plays Crucial Roles in Osteoclast Differentiation via Control of Actin Ring Formation

Lee HK, Park JC

PURPOSE: In osteoclast differentiation, actin-rich membrane protrusions play a crucial role in cell adhesion. Odontogenic ameloblast-associated protein (Odam) contributes to cell adhesion by inducing actin rearrangement. Odam-mediated RhoA activity may...
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In vitro treatment of lipopolysaccharide increases invasion of Pasteurella multocida serotype B:2 into bovine aortic endothelial cells

Yap SK, Zakaria Z, Othman SS, Omar AR

Pasteurella multocida serotype B:2 causes hemorrhagic septicemia in cattle and buffalo. The invasion mechanism of the bacterium when invading the bloodstream is unclear. This study aimed to characterize the effects...
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p53 and DNA-dependent protein kinase catalytic subunit independently function in regulating actin damage-induced tetraploid G1 arrest

Chae HD, Kim SY, Park SE, Kim J, Shin DY

We previously reported that the p53 tumor suppressor protein plays an essential role in the induction of tetraploid G1 arrest in response to perturbation of the actin cytoskeleton, termed actin...
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The Effects of Tranilast gamma on the Cellular Proliferation and alpha-Smooth Muscle Actin Expression in the Cultured Keratocytes of Rabbit

Lee JS, Jung SC

  • KMID: 2126071
  • J Korean Ophthalmol Soc.
  • 2004 Apr;45(4):668-674.
PURPOSE: To evaluate the effects of Tranilast gamma on the cellular proliferation and expression of alpha-smooth muscle actin on the cultured keratocytes of the rabbit that influence the formation of...
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p41-Arc, a regulatory subunit of Arp2/3 complex, can induce premature senescence in the absence of p53 and Rb

Yun UJ, Park SE, Shin DY

Cellular senescence is a tumor-suppressive process instigated by proliferation in the absence of telomere replication, by cellular stresses such as oncogene activation, or by activation of the tumor suppressor proteins,...
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Diverse Effects of Small Molecule Inhibitors on Actin Cytoskeleton Dynamics in HIV-1 Infection

Shin Y, Choi BS, Kim KC, Kim K, Yoon CH

The dynamics of the actin cytoskeleton plays a pivotal role in the process of cell division, the transportation of organelles, vesicle trafficking and cell movement. Human immunodeficiency virus type 1...
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Swiprosin-1 Regulates Cytokine Expression of Human Mast Cell Line HMC-1 through Actin Remodeling

Ramesh TP, Kim YD, Kwon MS, Jun CD, Kim SW

BACKGROUND: Swiprosin-1 was identified in human CD8+ lymphocytes, mature B cells and non-lymphonoid tissue. We have recently reported that swiprosin-1 is expressed in mast cells and up-regulated in both in...
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beta PAK-interacting exchange factor may regulate actin cytoskeleton through interaction with actin

Lee CS, Kim KY, Im JB, Choi JW, Kim HK, Park JS, Shin EY, Kim SR, Kim EG

  • KMID: 1103327
  • Exp Mol Med.
  • 2004 Dec;36(6):582-587.
p21-activated kinase (PAK)-interacting exchange factor (PIX) is known to be involved in regulation of Cdc42/Rac GTPases and PAK activity. PIX binds to the proline-rich region of PAK, and regulates biological...
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Effect of Pregnancy on Knee Joint Contracture in the Rat

Kim JS, Kang SY

  • KMID: 2323334
  • J Korean Acad Rehabil Med.
  • 1999 Dec;23(6):1095-1103.
OBJECTIVE: To study the effect of pregnancy on knee joint contracture in the rat, because the laxity of peripheral joint increases during pregnacy. METHOD: We evaluated the difference of contracture between...
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