- Toll-like Receptors and Innate Immunity
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Yuk JM, Jo EK
- KMID: 2168650
- J Bacteriol Virol.
- 2011 Dec;41(4):225-235.
- doi: 10.4167/jbv.2011.41.4.225
Toll-like receptors (TLRs) are the best-characterized membrane-bound receptors in innate immune cells, including macrophages and dendritic cells. Upon recognition of specific ligands originating from pathogen- and modified self-derived molecules, TLRs... -
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- Autophagy and bacterial infectious diseases
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Yuk JM, Yoshimori , Jo EK
- KMID: 1120128
- Exp Mol Med.
- 2012 Feb;44(2):99-108.
- doi: 10.3858/emm.2012.44.2.032
Autophagy is a housekeeping process that maintains cellular homeostasis through recycling of nutrients and degradation of damaged or aged cytoplasmic constituents. Over the past several years, accumulating evidence has suggested... -
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- The Role of Nitric Oxide in Mycobacterial Infections
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Yang CS, Yuk JM, Jo EK
- KMID: 1474594
- Immune Netw.
- 2009 Apr;9(2):46-52.
- doi: 10.4110/in.2009.9.2.46
Although tuberculosis poses a significant health threat to the global population, it is a challenge to develop new and effective therapeutic strategies. Nitric oxide (NO) and inducible NO synthase (iNOS)... -
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- Host immune responses to mycobacterial antigens and their implications for the development of a vaccine to control tuberculosis
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Yuk JM, Jo EK
- KMID: 1730620
- Clin Exp Vaccine Res.
- 2014 Jul;3(2):155-167.
- doi: 10.7774/cevr.2014.3.2.155
Tuberculosis (TB) remains a worldwide health problem, causing around 2 million deaths per year. Despite the bacillus Calmette Guerin vaccine being available for more than 80 years, it has limited... -
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- Expression of cytokines and co-stimulatory molecules in the Toxoplasma gondii-infected dendritic cells of C57BL/6 and BALB/c mice
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Lee JH, Yuk JM, Cha GH, Lee YH
- KMID: 2544821
- Parasit Host Dis.
- 2023 May;61(2):138-146.
- doi: 10.3347/PHD.22150
Toxoplasma gondii is an intracellular protozoan parasite which can infect most warm-blooded animals and humans. Among the different mouse models, C57BL/6 mice are more susceptible to T. gondii infection compared... -
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- The Role of PI3K/AKT Pathway and NADPH Oxidase 4 in Host ROS Manipulation by Toxoplasma gondii
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Choi HG, Gao FF, Zhou W, Sun PR, Yuk JM, Lee YH, Cha GH
- KMID: 2505091
- Korean J Parasitol.
- 2020 Jun;58(3):237-247.
- doi: 10.3347/kjp.2020.58.3.237
Dendritic cell is one of the first innate immune cell to encounter T. gondii after the parasite crosses the host intestinal epithelium. T. gondii requires intact DC as a carrier... -
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- Characterization of Proinflammatory Responses and Innate Signaling Activation in Macrophages Infected with Mycobacterium scrofulaceum
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Kim KH, Kim TS, Lee JG, Park JK, Yang M, Kim JM, Jo EK, Yuk JM
- KMID: 2150821
- Immune Netw.
- 2014 Dec;14(6):307-320.
- doi: 10.4110/in.2014.14.6.307
Mycobacterium scrofulaceum is an environmental and slow-growing atypical mycobacterium. Emerging evidence suggests that M. scrofulaceum infection is associated with cervical lymphadenitis in children and pulmonary or systemic infections in immunocompromised... -
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- Dipenyleneiodonium Induces Growth Inhibition of Toxoplasma gondii through ROS Induction in ARPE-19 Cells
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Sun PR, Gao FF, Choi HG, Zhou W, Yuk JM, Kwon J, Lee YH, Cha GH
- KMID: 2448139
- Korean J Parasitol.
- 2019 Apr;57(2):83-92.
- doi: 10.3347/kjp.2019.57.2.83
Based on the reactive oxygen species (ROS) regulatory properties of diphenyleneiodonium (DPI), we investigated the effects of DPI on host-infected T. gondii proliferation and determined specific concentration that inhibit the... -
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- Small Heterodimer Partner and Innate Immune Regulation
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Yuk JM, Jin HS, Jo EK
- KMID: 2169687
- Endocrinol Metab.
- 2016 Mar;31(1):17-24.
- doi: 10.3803/EnM.2016.31.1.17
The nuclear receptor superfamily consists of the steroid and non-steroid hormone receptors and the orphan nuclear receptors. Small heterodimer partner (SHP) is an orphan family nuclear receptor that plays an... -
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- 4-Hydroxybenzaldehyde Restricts the Intracellular Growth of Toxoplasma gondii by Inducing SIRT1-Mediated Autophagy in Macrophages
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lee J, Choi JW, Han HY, Kim WS, Song HY, Byun EB, Byun EH, Lee YH, Yuk JM
- KMID: 2501952
- Korean J Parasitol.
- 2020 Feb;58(1):7-14.
- doi: 10.3347/kjp.2020.58.1.7
Toxoplasma gondii is an intracellular protozoan parasite that infects approximately one third of the human popu- lation worldwide. Considering the toxicity and side effects of anti-toxoplasma medications, it is important... -
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- IL-12 and IL-23 Production in Toxoplasma gondii- or LPS-Treated Jurkat T Cells via PI3K and MAPK Signaling Pathways
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Ismail HA, Kang BH, Kim JS, Lee JH, Choi IW, Cha GH, Yuk JM, Lee YH
- KMID: 2403712
- Korean J Parasitol.
- 2017 Dec;55(6):613-622.
- doi: 10.3347/kjp.2017.55.6.613
IL-12 and IL-23 are closely related in structure, and have been shown to play crucial roles in regulation of immune responses. However, little is known about the regulation of these... -
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- Fasciola hepatica: Infection Status of Freshwater Snails Collected from Gangwon-do (Province), Korea
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Lee JH, Quan JH, Choi IW, Park GM, Cha GH, Kim HJ, Yuk JM, Lee YH
- KMID: 2374811
- Korean J Parasitol.
- 2017 Feb;55(1):95-98.
- doi: 10.3347/kjp.2017.55.1.95
Fasciola hepatica is a trematode that causes zoonosis, mainly in cattle and sheep, and occasionally in humans. Few recent studies have determined the infection status of this fluke in Korea.... -
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- Nitric Oxide Synthesis is Modulated by 1,25-Dihydroxyvitamin D3 and Interferon-gamma in Human Macrophages after Mycobacterial Infection
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Lee JS, Yang CS, Shin DM, Yuk JM, Son JW, Jo EK
- KMID: 1474580
- Immune Netw.
- 2009 Oct;9(5):192-202.
- doi: 10.4110/in.2009.9.5.192
BACKGROUND: Little information is available the role of Nitric Oxide (NO) in host defenses during human tuberculosis (TB) infection. We investigated the modulating factor(s) affecting NO synthase (iNOS) induction in... -
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- Involvement of PI3K/AKT and MAPK Pathways for TNF-alpha Production in SiHa Cervical Mucosal Epithelial Cells Infected with Trichomonas vaginalis
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Yang JB, Quan JH, Kim YE, Rhee YE, Kang BH, Choi IW, Cha GH, Yuk JM, Lee YH
- KMID: 2381753
- Korean J Parasitol.
- 2015 Aug;53(4):371-377.
- doi: 10.3347/kjp.2015.53.4.371
Trichomonas vaginalis induces proinflammation in cervicovaginal mucosal epithelium. To investigate the signaling pathways in TNF-alpha production in cervical mucosal epithelium after T. vaginalis infection, the phosphorylation of PI3K/AKT and MAPK... -
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