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Sodium/glucose Co-Transporter 2 Inhibitor, Empagliflozin, Alleviated Transient Expression of SGLT2 after Myocardial Infarction

Lee SY, Lee TW, Park GT, Kim JH, Lee HC, Han JH, Yoon A, Yoon D, Kim S, Jung SM, Choi JH, Chon MK, Lee SH, Hwang KW, Kim J, Park YH, Kim JH, Chun KJ, Hur J

Background and Objectives: Large clinical studies of sodium/glucose cotransporter 2 (SGLT2) inhibitors have shown a significant beneficial effect on heart failure-associated hospitalization and cardiovascular events. As SGLT2 is known to...
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Mesenchymal stem cells enable delivery of an oncolytic adenovirus specifically to the tumor without posing any risk associated with systemic administration of naked virions to the host

Yoon A, Hong J, Yun CO

Background: Systemic delivery oncolytic virus to tumors remains a major challenge due to its poor tumor tropism and immunogenicity. Methods: In this regard, we hypothesize that mesenchymal stem cells (MSCs) with...
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Activation of transforming growth factor-β and epithelialmesenchymal transition enhance regulatory T cells-mediated metastasis

Yoon A, Hong J, Yun CO

Background: Even though substantial portion of patients with melanoma diagnosis are present with distant metastases, the un-derlying oncogenic process remains unclear.  Methods: We have hypothesized that regulatory T cells (Tregs) play...
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Factors Affecting of Relevance Index of the Regional Public Hospital: Focused on Refined Diagnosis-Related Group Impacts

Yoon A, Woo KS, Shin YJ

BACKGROUND: An important function of the regional public hospital is to satisfy the basic medical needs of the community through the stable provision of high-quality medical services. The purpose of...
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The Versatility of Framework Regions of Chicken V(H) and V(L) to Mutations

Shin JW, Kim SI, Yoon A, Jin J, Park HB, Kim H, Chung J

To identify the interchangeability of V(H) and V(L) framework region (FR) residues, we artificially introduced random mutations at all residue positions in a chicken monoclonal antibody, which has only one...
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Genome-wide hepatic DNA methylation changes in high-fat diet-induced obese mice

Yoon A, Tammen SA, Park S, Han SN, Choi SW

BACKGROUND/OBJECTIVES: A high-fat diet (HFD) induces obesity, which is a major risk factor for cardiovascular disease and cancer, while a calorie-restricted diet can extend life span by reducing the risk...
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Next-generation sequencing enables the discovery of more diverse positive clones from a phage-displayed antibody library

Yang W, Yoon A, Lee S, Kim S, Han J, Chung J

Phage display technology provides a powerful tool to screen a library for a binding molecule via an enrichment process. It has been adopted as a critical technology in the development...
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Ig-like domain 6 of VCAM-1 is a potential therapeutic target in TNFα-induced angiogenesis

Kim TK, Park CS, Na HJ, Lee K, Yoon A, Chung J, Lee S

Tumor necrosis factor alpha (TNFα)-induced angiogenesis plays important roles in the progression of various diseases, including cancer, wet age-related macular degeneration, and rheumatoid arthritis. However, the relevance and role of...
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A phosphorylation pattern-recognizing antibody specifically reacts to RNA polymerase II bound to exons

Han J, Lee JH, Park S, Yoon S, Yoon A, Hwang DB, Lee HK, Kim MS, Lee Y, Yang WJ, Youn HD, Kim H, Chung J

The C-terminal domain of RNA polymerase II is an unusual series of repeated residues appended to the C-terminus of the largest subunit and serves as a flexible binding scaffold for...
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Food Allergy Management Status by Dietitians and Nutrition Teachers in Elementary and Middle Schools in Incheon

Yoon A, Lee SK

OBJECTIVES: Food allergy appears to be increasing in prevalence and can potentially result in significant damaging impact on children's mental and physical health. This study investigated how dietitians/nutrition teachers in...
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Pulmonary metastasectomy in uterine malignancy: outcomes and prognostic factors

Paik ES, Yoon A, Lee YY, Kim TJ, Lee JW, Bae DS, Kim BG

OBJECTIVE: The aim of this study was to investigate outcomes in uterine cancer patients undergoing pulmonary metastasectomy and prognostic factors associated with survival after the procedure. METHODS: A retrospective study was...
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Tributyltin increases the expression of apoptosis- and adipogenesis-related genes in rat ovaries

Lee H, Lim S, Yun S, Yoon A, Park G, Yang H

OBJECTIVE: Tributyltin (TBT), an endocrine disrupting chemical, has been reported to decrease ovarian function by causing apoptosis in the ovary, but the mechanism is not fully understood. Therefore, we examined...
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Primary signet ring cell carcinoma of the uterine cervix: A case report

Yoon A, Kim SH, Kim HJ, Bae DS, Lee JW

Primary signet ring cell carcinoma of the cervix is extremely rare. A 47-year-old woman visited for postcoital vaginal bleeding during the last six months. Gynecologic examination revealed mild cervical erosion...
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Single-port access laparoscopic staging operation for a borderline ovarian tumor

Yoon A, Kim TJ, Lee WS, Kim BG, Bae DS

Minimally invasive surgery is widely used in benign gynecologic diseases and may be used in malignancies. We performed a single-port access laparoscopy staging - bilateral salpingo-oophorectomy, laparoscopy-assisted vaginal hysterectomy, bilateral...
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