- Ubiquitin Ligases in Cholesterol Metabolism
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Jiang W, Song BL
- KMID: 2280686
- Diabetes Metab J.
- 2014 Jun;38(3):171-180.
- doi: 10.4093/dmj.2014.38.3.171
To maintain cholesterol homeostasis, the processes of cholesterol metabolism are regulated at multiple levels including transcription, translation, and enzymatic activity. Recently, the regulation of protein stability of some key players... -
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- Proteolytic Regulation of Retinoblastoma Family Protein p107 by Ubiquitin - proteasome Pathway
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Jang JS, Park BK, Hwang SG
- KMID: 2175114
- J Korean Cancer Assoc.
- 2000 Apr;32(2):417-421.
PURPOSE: Proteolysis is an important way to regulate cell cycle regulatory proteins. Ubiquitin- proteasome pathway regards as highly selective proteolytic machinary mostly in physiological state. We investigated the role of ubiquitin-proteasome pathway... -
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- The Ubiquitin-Proteasome System and F-box Proteins in Pathogenic Fungi
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Liu TB, Xue C
- KMID: 2312649
- Mycobiology.
- 2011 Dec;39(4):243-248.
The ubiquitin-proteasome system is one of the major protein turnover mechanisms that plays important roles in the regulation of a variety of cellular functions. It is composed of E1 (ubiquitin-activating... -
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- Regulation of Cellular Antiviral Signaling by Modifications of Ubiquitin and Ubiquitin-like Molecules
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Li K, Zhong B
- KMID: 2404889
- Immune Netw.
- 2018 Feb;18(1):e4.
- doi: 10.4110/in.2018.18.e4
The initiation of cellular antiviral signaling depends on host pattern-recognition receptors (PRRs)-mediated recognition of viral nucleic acids that are known as classical pathogen-associated molecular patterns (PAMPs). PRRs recruit adaptor proteins... -
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- HIF-1alpha Upregulation due to Depletion of the Free Ubiquitin Pool
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Kim J, So D, Shin HW, Chun YS, Park JW
- KMID: 2344170
- J Korean Med Sci.
- 2015 Oct;30(10):1388-1395.
- doi: 10.3346/jkms.2015.30.10.1388
Hypoxia-inducible factor 1alpha (HIF-1alpha), which transactivates a variety of hypoxia-induced genes, is rapidly degraded under nomoxia through the hydroxylation-ubiquitination-proteasome pathway. In this study, we addressed how HIF-1alpha is stabilized by... -
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- Expression of Ubiquitin and Neural Cell Adhesion Molecule in the Muscles of Spastic Cerebral Palsy Patients
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Jung SH, Hahn SB, Kong SY, Kim HW
- KMID: 2023979
- J Korean Orthop Res Soc.
- 2007 Apr;10(1):35-43.
PURPOSE: This study was performed to examine the histopathologic changes of muscles and the expression patterns of ubiquitin and N-CAM (neural cell adhesion molecule) in accordance with cerebral palsy patient's... -
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- Ubiquitin C-terminal Hydrolase L1 Regulates Lipid Raft-dependent Endocytosis
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Kang SJ, Kim JS, Park SM
- KMID: 2424732
- Exp Neurobiol.
- 2018 Oct;27(5):377-386.
- doi: 10.5607/en.2018.27.5.377
Ubiquitin C-terminal hydrolase L1 (UCH-L1) is a deubiquitinating enzyme that is highly expressed in neurons, and gathering evidence indicates that UCH-L1 may play pathogenic roles in many neurodegenerative disorders such... -
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- The Role of Tripartite Motif Family Proteins in TGF-β Signaling Pathway and Cancer
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Lee HJ
- KMID: 2447447
- J Cancer Prev.
- 2018 Dec;23(4):162-169.
- doi: 10.15430/JCP.2018.23.4.162
TGF-β signaling plays a tumor suppressive role in normal and premalignant cells but promotes tumor progression during the late stages of tumor development. The TGF-β signaling pathway is tightly regulated... -
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- Regulation of Protein Degradation by Proteasomes in Cancer
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Jang HH
- KMID: 2447446
- J Cancer Prev.
- 2018 Dec;23(4):153-161.
- doi: 10.15430/JCP.2018.23.4.153
Imbalance of protein homeostasis (proteostasis) is known to cause cellular malfunction, cell death, and diseases. Elaborate regulation of protein synthesis and degradation is one of the important processes in maintaining... -
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- Ubiquitination of Aquaporin: in the kidney
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Lee YJ, Kwon TH
- KMID: 1464781
- Electrolyte Blood Press.
- 2009 Jun;7(1):1-4.
- doi: 10.5049/EBP.2009.7.1.1
Ubiquitination is known to be important for endocytosis and lysosomal degradation of aquaporin-2 (AQP2). Ubiquitin (Ub) is covalently attached to the lysine residue of the substrate proteins and activation and... -
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- Pja2 Inhibits Wnt/β-catenin Signaling by Reducing the Level of TCF/LEF1
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Song Y, Lee S, Kim JR, Jho EH
- KMID: 2429557
- Int J Stem Cells.
- 2018 Nov;11(2):242-247.
- doi: 10.15283/ijsc18032
Ubiquitination of proteins plays an essential role in various cellular processes, including protein degradation, DNA repair, and cell signaling pathways. Previous studies have shown that protein ubiquitination is implicated in... -
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- F-box only protein 9 is an E3 ubiquitin ligase of PPARγ
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Lee KW, Kwak SH, Koo YD, Cho YK, Lee HM, Jung HS, Cho YM, Park YJ, Chung SS, Park KS
- KMID: 2361521
- Exp Mol Med.
- 2016 May;48(5):e234.
- doi: 10.1038/emm.2016.31
Peroxisome proliferator-activated receptor gamma (PPARγ) is a critical regulator of carbohydrate and lipid metabolism, adipocyte differentiation and inflammatory response. Post-translational modification of PPARγ and its degradation involve several pathways, including... -
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- Purification and Identification of Ubiquitin Binding Proteins from Erythrocytes of Patients with Dementia
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Kim HS, Cheon JS, Oh BH, Lee SJ
- KMID: 2186206
- J Korean Geriatr Psychiatry.
- 2003 Jun;7(1):57-66.
OBJECTIVE: The continuous synthesis and degradation of proteins in the cell are essential for the maintenance of cellular homeostasis. Intracellular protein degradation largely occurs in the lysosome and cytoplasm. The... -
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- Ubiquitin E3 Ligase Pellino-1 Inhibits IL-10-mediated M2c Polarization of Macrophages, Thereby Suppressing Tumor Growth
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Kim D, Koh J, Ko JS, Kim HY, Lee H, Chung DH
- KMID: 2461196
- Immune Netw.
- 2019 Oct;19(5):e32.
- doi: 10.4110/in.2019.19.e32
Pellino-1 is a ubiquitin (Ub) E3 ligase that plays a role in M1, but not M2a polarization of macrophages. However, it is unknown whether Pellino-1 regulates IL-10-mediated M2c polarization of... -
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- Modulating cellular balance of Rps3 mono-ubiquitination by both Hel2 E3 ligase and Ubp3 deubiquitinase regulates protein quality control
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Jung Y, Kim HD, Yang HW, Kim HJ, Jang CY, Kim J
- KMID: 2396795
- Exp Mol Med.
- 2017 Nov;49(11):e390.
- doi: 10.1038/emm.2017.128
When a ribosome complex is stalled during the translation elongation process in eukaryotes, the mono-ubiquitination of Rps3 has recently been shown to be critical to ribosome quality control. We have... -
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- Selective expression of death receptor 4 and induction of apoptosis by HPV E6
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Choi E, Koh H, Shin S, Kim K
- KMID: 2244946
- Korean J Gynecol Oncol Colposc.
- 2002 Jun;13(2):139-145.
Human papillomaviruses, especially type 16 and 18, have been known to be closely associated with human cervix cancer. The E6 and E7 proteins encoded by these viruses disrupt normal cell... -
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- Herpesvirus-encoded Deubiquitinating Proteases and Their Roles in Regulating Immune Signaling Pathways
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Kwon KM, Ahn JH
- KMID: 1501992
- J Bacteriol Virol.
- 2013 Dec;43(4):244-252.
- doi: 10.4167/jbv.2013.43.4.244
Viruses interact with the host ubiquitination system in a variety of ways. Viral proteins are often a substrate for ubiquitination, which leads to proteasomal degradation. Viruses also have functions to... -
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- DNA-Damage Inducible 1 is a Property of Human Non-Small Cell Lung Cancer
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Lee JY, Kang E, Lim BJ, Chang YS, Kim SK
- KMID: 2319731
- Tuberc Respir Dis.
- 2012 Feb;72(2):124-131.
BACKGROUND: DNA damage-inducible 1 (Ddi1), one of the ubiquitin-like and ubiquitin-associated family of proteins, may function in the regulation of the ubiquitin-proteasome pathway, which has been validated as a target... -
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- Cytoskeletal Changes in Cortical Dysplasia
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Lee MY, Chung JH, Woo YJ, Kim HI, Lee MC
- KMID: 1979395
- Korean J Pathol.
- 2000 Apr;34(4):300-309.
Cortical dysplasia is a cause of intractable epilepsy and a candidate for surgical resection to control epileptic attacks. The neuronal cytomegaly and balloon cell change are the diagnostic hallmarks of... -
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- The Molecular Biologic Study about the Role of Deubiquitination Gene in Bladder Tumor Progression
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Kim HY, Lee YG, Lee SE
- KMID: 2292517
- Korean J Urol.
- 2002 Dec;43(12):1019-1023.
PURPOSE: Ubiqutin-proteasome-mediated proteolysis is an important pathway of nonlysosomal protein degradation, which controls the timed destruction of cellular regulatory proteins of the p21, p27, p53 gene (p53), Retinoblastoma gene (Rb),... -
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