- Macrophages in xenotransplantation
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Kim JY
- KMID: 2468157
- Korean J Transplant.
- 2019 Dec;33(4):74-82.
- doi: 10.4285/jkstn.2019.33.4.74
Xenotransplantation refers to organ transplantation across species. Immune rejection of xenografts is stronger and faster than that of allografts because of significant molecular differences between species. Recent studies have revealed... -
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- Olaparib induced senescence under P16 or P53 dependent manner in ovarian cancer
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Wang Z, Gao J, Zhou J, Liu H, Xu C
- KMID: 2457138
- J Gynecol Oncol.
- 2019 Mar;30(2):e26.
- doi: 10.3802/jgo.2019.30.e26
OBJECTIVE: Poly (ADP-ribose) polymerase (PARP) is an important molecule in the early stress response of DNA damage, which is involved in DNA damage repair and cellular senescence. Olaparib, as PARP... -
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- Establishment and identification of cell lines from type O blood Korean native pigs and their efficiency in supporting embryonic development via somatic cell nuclear transfer
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Taweechaipaisankul A, Kim GA, Jin JX, Yeom SC, Lee BC
- KMID: 2417563
- J Vet Sci.
- 2018 Jul;19(4):492-499.
- doi: 10.4142/jvs.2018.19.4.492
Due to their similarities with humans in anatomy, physiology, and genetics miniature pigs are becoming an attractive model for biomedical research. We aim to establish and evaluate blood type O... -
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- Xenotransplantation of Cultured Human Corneal Endothelial Cell Sheets
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Lee YP, Chung TY, Hyon JY, Shin YJ
- KMID: 2413811
- J Korean Ophthalmol Soc.
- 2018 Jun;59(6):497-504.
- doi: 10.3341/jkos.2018.59.6.497
PURPOSE: To investigate the possibility of transplantation into rabbits of collagenase-induced cultured human corneal endothelial cell plate-rabbit corneal stromal complexes. METHODS: Human corneal endothelial cells were isolated from residual corneal limbus... -
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- Analysis of swine leukocyte antigen class I gene profiles and porcine endogenous retrovirus viremia level in a transgenic porcine herd inbred for xenotransplantation research
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Matczyńska D, Sypniewski D, Gałka S, Sołtysik , Loch T, Nowak E, Smorąg Z, Bednarek I
- KMID: 2412129
- J Vet Sci.
- 2018 May;19(3):384-392.
- doi: 10.4142/jvs.2018.19.3.384
Molecular characterization of swine leukocyte antigen (SLA) genes is important for elucidating the immune responses between swine-donor and human-recipient in xenotransplantation. Examination of associations between alleles of SLA class I... -
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- Enrichment and In Vitro Culture of Spermatogonial Stem Cells from Pre-Pubertal Monkey Testes
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Kim YH, Kang HG, Kim BJ, Jung SE, Karmakar P, Kim SM, Hwang S, Ryu BY
- KMID: 2394989
- Tissue Eng Regen Med.
- 2017 Oct;14(5):557-566.
- doi: 10.1007/s13770-017-0058-x
Spermatogonial stem cells (SSCs) are essential for spermatogenesis throughout the lifespan of the male. However, the rarity of SSCs has raised the need for an efficient selection method, but little... -
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- Non-invasive Myocardial Strain Imaging to Evaluate Graft Failure in Cardiac Xenotransplantation
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Yang HS, Chee HK, Kim JS, Kim WS, Park JH, Shin KC, Park KS, Lee SW, Cho KH, Park WJ, Oh KB, Ahn C, Yun IJ
- KMID: 2375677
- J Korean Soc Transplant.
- 2017 Mar;31(1):25-33.
- doi: 10.4285/jkstn.2017.31.1.25
BACKGROUND: The shortage of human hearts for allotransplantation makes xenotransplantation a possible option for controllable organ providers. To detect acute xenograft rejection, invasive biopsy seems inevitable; however, this occasionally results... -
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- Intra-articular Xenotransplantation of Adipose-Derived Stromal Cells to Treat Osteoarthritis in a Goat Model
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Ko JY, Lee J, Lee J, Im GI
- KMID: 2371105
- Tissue Eng Regen Med.
- 2017 Feb;14(1):65-71.
- doi: 10.1007/s13770-016-0010-5
Adipose-derived stromal cells (ASCs) have been investigated as a cell source for tissue regeneration. The purpose of this study was first to confirm if medial meniscectomy induces osteoarthritis (OA) in... -
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- Eukaryotic Translation Initiation Factor 3a (eIF3a) Promotes Cell Proliferation and Motility in Pancreatic Cancer
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Wang SQ, Liu Y, Yao MY, Jin J
- KMID: 2468249
- J Korean Med Sci.
- 2016 Oct;31(10):1586-1594.
- doi: 10.3346/jkms.2016.31.10.1586
Identifying a target molecule that is crucially involved in pancreatic tumor growth and metastasis is necessary in developing an effective treatment. The study aimed to investigate the role of the... -
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- Ultrasound-Guided Delivery of siRNA and a Chemotherapeutic Drug by Using Microbubble Complexes: In Vitro and In Vivo Evaluations in a Prostate Cancer Model
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Bae YJ, Yoon YI, Yoon TJ, Lee HJ
- KMID: 2455420
- Korean J Radiol.
- 2016 Aug;17(4):497-508.
- doi: 10.3348/kjr.2016.17.4.497
OBJECTIVE: To evaluate the effectiveness of ultrasound and microbubble-liposome complex (MLC)-mediated delivery of siRNA and doxorubicin into prostate cancer cells and its therapeutic capabilities both in vitro and in vivo. MATERIALS... -
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- OTX1 Contributes to Hepatocellular Carcinoma Progression by Regulation of ERK/MAPK Pathway
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Li H, Miao Q, Xu CW, Huang JH, Zhou YF, Wu MJ
- KMID: 2373748
- J Korean Med Sci.
- 2016 Aug;31(8):1215-1223.
- doi: 10.3346/jkms.2016.31.8.1215
Orthodenticlehomeobox 1 (OTX1) overexpression had previously been associated with the progression of several tumors. The present study aimed to determine the expression and role of OTX1 in human hepatocellular carcinoma... -
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- Current Status of Solid Organ Xenotransplantation
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Yun IJ
- KMID: 2327965
- J Korean Soc Transplant.
- 2016 Jun;30(2):69-76.
- doi: 10.4285/jkstn.2016.30.2.69
Solid organ xenotransplantation using transgenic pig organs is proposed as an alternative method for allo-transplantation. To accomplish this, immunologic and non-immunologic barriers for xenotransplantation should be overcome, and experiments on... -
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- Implications of Calcineurin/NFAT Inhibitors' Regulation of Dendritic Cells and Innate Immune Cells in Islet Xenotransplantation
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Kim YH, Lee WW, Park CG
- KMID: 2168737
- J Bacteriol Virol.
- 2016 Mar;46(1):1-12.
- doi: 10.4167/jbv.2016.46.1.1
Calcineurin inhibitors, such as cyclosporine and tacrolimus (FK506) are broadly used in organ transplantations as immune suppressants. As the calcineurin/NFAT signaling pathway has been identified as critical pathway in the... -
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- Successful Xenograft of Endoscopic Ultrasound-Guided Fine-Needle Aspiration Specimen from Human Extrahepatic Cholangiocarcinoma into an Immunodeficient Mouse
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Jang SY, Bae HI, Lee IK, Park HK, Cho CM
- KMID: 2377940
- Gut Liver.
- 2015 Nov;9(6):805-808.
- doi: 10.5009/gnl14279
Patient-derived tumor xenograft is the transfer of primary human tumors directly into an immunodeficient mouse. Patient-derived tumor xenograft plays an important role in the development and evaluation of new chemotherapeutic... -
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- Increase in Anti-Gal IgM Level is Associated With Early Graft Failure in Intraportal Porcine Islet Xenotransplantation
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Kang HJ, Lee H, Park EM, Kim JM, Shin JS, Kim JS, Park CG, Kim SJ
- KMID: 2363264
- Ann Lab Med.
- 2015 Nov;35(6):611-617.
- doi: 10.3343/alm.2015.35.6.611
BACKGROUND: Anti-Gal is a major antibody induced in non-human primates (NHPs) after xenotransplantation. To understand the mechanism of graft rejection, we investigated the association between anti-Gal responses and graft failure... -
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- Islet Encapsulation Using Chondrocyte
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Lee JI, Kim JY, Lee JG, Kim YS
- KMID: 1941312
- J Korean Soc Transplant.
- 2014 Dec;28(4):187-194.
- doi: 10.4285/jkstn.2014.28.4.187
Diabetes mellitus is one of the leading metabolic diseases that cause an increasing rate of mortality and morbidity. Recently, rather than the current drug treatment, pancreatic islet transplantation has been... -
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- Effects of Platelet-Rich Plasma, Adipose-Derived Stem Cells, and Stromal Vascular Fraction on the Survival of Human Transplanted Adipose Tissue
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Kim DY, Ji YH, Kim DW, Dhong ES, Yoon ES
- KMID: 2151413
- J Korean Med Sci.
- 2014 Nov;29(Suppl 3):S193-S200.
- doi: 10.3346/jkms.2014.29.S3.S193
Traditional adipose tissue transplantation has unpredictable viability and poor absorption rates. Recent studies have reported that treatment with platelet-rich plasma (PRP), adipose-derived stem cells (ASCs), and stromal vascular fraction (SVF)... -
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- Intratumoral Heterogeneity of Breast Cancer Xenograft Models: Texture Analysis of Diffusion-Weighted MR Imaging
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Yun BL, Cho N, Li M, Jang MH, Park SY, Kang HC, Kim B, Song IC, Moon WK
- KMID: 1734944
- Korean J Radiol.
- 2014 Oct;15(5):591-604.
- doi: 10.3348/kjr.2014.15.5.591
OBJECTIVE: To investigate whether there is a relationship between texture analysis parameters of apparent diffusion coefficient (ADC) maps and histopathologic features of MCF-7 and MDA-MB-231 xenograft models. MATERIALS AND METHODS: MCF-7... -
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- Evaluation of biocompatibility of alpha-1,3 galactosyltransferase knockout pig bone graft in a rat calvarial defect model
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Kim SE, Choi GH, Shim KM, Choi SH, Lee SM, Kang SS
- KMID: 1709210
- J Biomed Res.
- 2014 Jun;15(2):86-91.
The current study was conducted to evaluate the biocompatibility of alpha-1,3 galactosyltransferase knockout pig bone graft in a rat calvarial defect model. Porcine cancellous bones were harvested from general and... -
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- No expression of porcine endogenous retrovirus after pig to monkey xenotransplantation
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Hwang S, Jung YD, Cho K, Ock SA, Oh KB, Kim HS, Yun IJ, Ahn C, Park JK, Im S
- KMID: 1707449
- Lab Anim Res.
- 2014 Jun;30(2):90-93.
- doi: 10.5625/lar.2014.30.2.90
This study was performed to investigate the expression of two porcine endogenous retrovirus (PERV) elements, PERV gag and full-length conserved PERV, in blood cells collected periodically from organ-recipient monkeys that... -
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