- Modulation of transglutaminase expression in rat skeletal muscle by induction of atrophy and endurance training
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Park SC, Kim WH, Lee MC, Seong SC, Song KY, Choe MA
- KMID: 644841
- J Korean Med Sci.
- 1994 Dec;9(6):490-496.
- doi: 10.3346/jkms.1994.9.6.490
The persistence of muscle fiber number regardless of size reduction in muscle atrophy has not yet been fully explained. For the mechanism inherent in skeletal muscle tissues for preventing cellular... -
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- Transglutaminase 2 Expression and Its Prognostic Significance in Clear Cell Renal Cell Carcinoma
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Park MJ, Baek HW, Rhee YY, Lee C, Park JW, Kim HW, Moon KC
- KMID: 2381351
- J Pathol Transl Med.
- 2015 Jan;49(1):37-43.
- doi: 10.4132/jptm.2014.10.25
BACKGROUND: A few recent studies have demonstrated a possible role of transglutaminase 2 (TG2) in tumorigenesis or progression of renal cell carcinoma (RCC). The aim of this study was to... -
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- Role of crosslinked protein in lung injury following total body irradiation and bone marrow transplantation
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Lee SY, Kim YJ, Kim YJ
- KMID: 1119340
- Exp Mol Med.
- 2003 Dec;35(6):565-571.
The aberrant protein crosslinks formation during lung injury as results total body irradiation (TBI) and bone marrow transplantation (BMT) therapy has been examined as apossible contributory factor in organ or... -
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- Intimal Hyperplasia in Loop-Injured Carotid Arteries Is Attenuated in Transglutaminase 2-Null Mice
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Min SK, Min SI, Jeong EM, Cho SY, Ha J, Kim SJ, Kim IG
- KMID: 1734923
- J Korean Med Sci.
- 2014 Mar;29(3):363-369.
- doi: 10.3346/jkms.2014.29.3.363
Arterial restenosis frequently develops after open or endovascular surgery due to intimal hyperplasia. Since tissue transglutaminase (TG2) is known to involve in fibrosis, wound healing, and extracellular matrix remodeling, we... -
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- Differential gene expression of transglutaminase 2 in term pregnancy with and without labor
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Kim OK, Kim A, Seo MW, Ahn HY, Yang DE, Lee GS, Shin JC
- KMID: 2273344
- Korean J Obstet Gynecol.
- 2008 May;51(5):510-517.
OBJECTIVE: Our purpose was to investigate transglutaminase 2 (TGM2) mRNA and protein expressions in term placentas and fetal membranes delivered with labor compared to no labor. METHODS: Samples were obtained from... -
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- Cell Surface Tissue Transglutaminase-induced Activation of Phosphoinositol 3-Kinase/Akt Pathway
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Kim SO, Kim MK, Lee SS, Cho BR, Kim DJ
- KMID: 2071919
- Korean J Phys Anthropol.
- 2009 Sep;22(3):245-254.
Multifunctional tissue transglutaminase (tTGase) is found in the cytoplasm and cell surface, as well as in the extracellular matrix. However, it is difficult to determine the exact function of tTGase... -
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- A Novel Therapeutic Target in Inflammatory Uveitis: Transglutaminase 2 Inhibitor
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Sohn J, Chae JB, Lee SY, Kim SY, Kim JG
- KMID: 1098790
- Korean J Ophthalmol.
- 2010 Feb;24(1):29-34.
- doi: 10.3341/kjo.2010.24.1.29
PURPOSE: Our goal was to investigate the effects of inhibition of transglutaminase 2 (TGase 2) on endotoxin-induced uveitis (EIU) METHODS: EIU was induced in female Lewis rats by single footpad... -
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- Biomarkers Predicting Isocyanate-Induced Asthma
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Palikhe NS, Kim JH, Park HS
- KMID: 2260373
- Allergy Asthma Immunol Res.
- 2011 Jan;3(1):21-26.
- doi: 10.4168/aair.2011.3.1.21
Three diisocyanates can cause occupational asthma (OA): toluene diisocyanate (TDI), 4,4 diphenylmethane diisocyanate (MDI), and 1,6-hexamethylene diisocyanate (HDI). We analyzed potential biomarkers of isocyanate-induced OA, based on investigated immunologic, genetic,... -
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- Effects of Transglutaminase 2 Inhibition on Ventilator-Induced Lung Injury
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Suh IB, Yoon DW, Oh WO, Lee EJ, Min KH, Hur GY, Lee SH, Lee SY, Lee SY, Shin C, Shim JJ, In KH, Kang KH, Kim JH
- KMID: 1774462
- J Korean Med Sci.
- 2014 Apr;29(4):556-563.
- doi: 10.3346/jkms.2014.29.4.556
This study was performed to examine the role of transglutaminase 2 (TG2) in ventilator-induced lung injury (VILI). C57BL/6 mice were divided into six experimental groups: 1) control group; 2) lipopolysaccharide... -
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- Transglutaminase 2 Expression Predicts Progression Free Survival in Non-Small Cell Lung Cancer Patients Treated with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor
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Jeong JH, Cho BC, Shim HS, Kim HR, Lim SM, Kim SK, Chung KY, Islam SM, Song JJ, Kim SY, Kim JH
- KMID: 1777495
- J Korean Med Sci.
- 2013 Jul;28(7):1005-1014.
- doi: 10.3346/jkms.2013.28.7.1005
Transglutaminase 2 (TG2), a cross-linking enzyme, is involved in drug resistance and in the constitutive activation of nuclear factor kappa B (NF-kappaB). We investigated the association of non-small cell lung... -
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- Different inhibition characteristics of intracellular transglutaminase activity by cystamine and cysteamine
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Jeon JH, Lee HJ, Jang GY, Kim CW, Shin DM, Cho SY, Yeo EJ, Park SC, Kim IG
- KMID: 1103326
- Exp Mol Med.
- 2004 Dec;36(6):576-581.
The treatment of cystamine, a transglutaminase (TGase) inhibitor, has beneficial effects in several diseases including CAG-expansion disorders and cataract. We compared the inhibition characteristics of cystamine with those of cysteamine,... -
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- A model for the reaction mechanism of the transglutaminase 3 enzyme
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Ahvazi B, Steinert P
- KMID: 1109310
- Exp Mol Med.
- 2003 Aug;35(4):228-242.
Transglutaminase enzymes (TGases) catalyze the calcium dependent formation of an isopeptide bond between protein-bound glutamine and lysine substrates. Previously we have shown that activated TGase 3 acquires two additional calcium... -
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- Tissue Transglutaminase Autoantibodies in Patients with IgM Rheumatoid Factors
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Song KS, Choi JR
- KMID: 1103926
- Yonsei Med J.
- 2004 Oct;45(5):960-962.
- doi: 10.3349/ymj.2004.45.5.960
The recent identification of tissue transglutaminase (tTG) as the autoantigen for celiac disease-associated anti-endomysial antibodies (EMA) has allowed the use of rapid immunoassay to detect the presence of autoantibodies, anti-tTG,... -
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- Transglutaminase 2 inhibits apoptosis induced by calciumoverload through down-regulation of Bax
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Cho SY, Lee JH, Bae HD, Jeong EM, Jang GY, Kim CW, Shin DM, Jeon JH, Kim IG
- KMID: 983956
- Exp Mol Med.
- 2010 Sep;42(9):639-650.
- doi: 10.3858/emm.2010.42.9.063
An abrupt increase of intracellular Ca2+ is observed in cells under hypoxic or oxidatively stressed conditions. The dysregulated increase of cytosolic Ca2+ triggers apoptotic cell death through mitochondrial swelling and... -
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