- Transcriptional induction of DLC-1 gene through Sp1 sites by histone deacetylase inhibitors in gastric cancer cells
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Kim TY, Kim IS, Jong HS, Lee JW, Kim TY, Jung M, Bang YJ
- KMID: 1072944
- Exp Mol Med.
- 2008 Dec;40(6):639-646.
- doi: 10.3858/emm.2008.40.6.639
We previously reported that trichostatin A (TSA), a histone deacetylase (HDAC) inhibitor, induced DLC-1 mRNA expression and accumulated acetylated histones H3 and H4 associated with the DLC-1 promoter in DLC-1... -
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- The mutational landscape of hepatocellular carcinoma
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Lee JS
- KMID: 2351021
- Clin Mol Hepatol.
- 2015 Sep;21(3):220-229.
- doi: 10.3350/cmh.2015.21.3.220
The development of hepatocellular carcinoma (HCC) is a complex process, and HCC arises from the accumulation of multiple genetic alterations leading to changes in the genomic landscape. Current advances in... -
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- Neural cell adhesion molecule (NCAM) promotes the differentiation of hippocampal precursor cells to a neuronal lineage, especially to a glutamatergic neural cell type
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Shin MH, Lee EG, Lee SH, Lee YS, Son H
- KMID: 1121093
- Exp Mol Med.
- 2002 Dec;34(6):401-410.
Rat hippocampal precursor cells isolated from hippocampi of embryonic day 16.5 (E16.5) rat embryos were found to proliferate in the presence of basic fibroblast growth factor. Addition of soluble... -
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- Constitutive stabilization of hypoxia-inducible factor alpha selectively promotes the self-renewal of mesenchymal progenitors and maintains mesenchymal stromal cells in an undifferentiated state
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Park IH, Kim KH, Choi HK, Shim JS, Whang SY, June Hahn , Kwon OJ, Oh IH
- KMID: 2154263
- Exp Mol Med.
- 2013 Sep;45(9):e44.
With the increasing use of culture-expanded mesenchymal stromal cells (MSCs) for cell therapies, factors that regulate the cellular characteristics of MSCs have been of major interest. Oxygen concentration has been... -
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- Cyclooxygenase-2 Expression Is Related to the Epithelial-to-Mesenchymal Transition in Human Colon Cancers
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Jang TJ, Jeon KH, Jung KH
- KMID: 1777097
- Yonsei Med J.
- 2009 Dec;50(6):818-824.
- doi: 10.3349/ymj.2009.50.6.818
PURPOSE: Down-regulation of E-cadherin is a hallmark of the epithelial-to-mesenchymal transition (EMT). EMT progression in cancer cells is associated with the loss of certain epithelial markers and the acquisition of... -
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- Isolation and Characterization of Chorionic Mesenchymal Stromal Cells from Human Full Term Placenta
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Koo BK, Park IY, Kim J, Kim JH, Kwon A, Kim M, Kim Y, Shin JC, Kim JH
- KMID: 1714195
- J Korean Med Sci.
- 2012 Aug;27(8):857-863.
- doi: 10.3346/jkms.2012.27.8.857
This study focused on the characterization of mesenchymal stromal cells (MSCs) from the chorion of human full term placenta from 15 donors. Chorionic MSCs revealed homologous fibroblast-like morphology and expressed... -
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- 5-azacytidine induces cardiac differentiation of P19 embryonic stem cells
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Choi SC, Yoon JH, Shim WJ, Ro YM, Lim DS
- KMID: 1103318
- Exp Mol Med.
- 2004 Dec;36(6):515-523.
The P19 embryonal carcinoma cell line is a useful model cells for studies on cardiac differentiation. However, its low efficacy of differentiation hampers its usefulness. We investigated the effect of... -
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- Detection of antibodies against glucose 6-phosphate isomerase in synovial fluid of rheumatoid arthritis using surface plasmon resonance (BIAcore)
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Kim JY, Lee MH, Jung KI, Na HY, Cha HS, Ko EM, Kim TJ
- KMID: 1109321
- Exp Mol Med.
- 2003 Aug;35(4):310-316.
We have used a surface plasmon resonance biosensor (SPR, BIACORE 2000) to detect antibodies against glucose 6-phosphate isomerase (GPI) in synovial fluids of rheumatoid arthritis (RA) and osteoarthritis (OA). Recombinant... -
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- p53 gene transfer does not enhance E2F-1-mediated apoptosis in human colon cancer cells
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Draus JM, Elliott MJ, Atienza C, Stilwell A, Wong SL, Dong Y, Yang H, McMasters
- KMID: 1457532
- Exp Mol Med.
- 2001 Dec;33(4):209-219.
E2F-1 and p53 are sequence specific transcription factors that are intimately involved in the regulation of the cell cycle. In addition to their role in cell cycle control, both E2F-1... -
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- Dual-Blocking of PI3K and mTOR Improves Chemotherapeutic Effects on SW620 Human Colorectal Cancer Stem Cells by Inducing Differentiation
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Kim MJ, Koo JE, Han GY, Kim B, Lee YS, Ahn C, Kim CW
- KMID: 2363495
- J Korean Med Sci.
- 2016 Mar;31(3):360-370.
- doi: 10.3346/jkms.2016.31.3.360
Cancer stem cells (CSCs) have tumor initiation, self-renewal, metastasis and chemo-resistance properties in various tumors including colorectal cancer. Targeting of CSCs may be essential to prevent relapse of tumors after... -
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