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CD24⁺ Cell Depletion Permits Effective Enrichment of Thymic iNKT Cells While Preserving Their Subset Composition

Park JY, Kwon J, Kim EY, Fink J, Kim HK, Park JH

Invariant NKT (iNKT) cells are a small subset of thymus-generated T cells that produce cytokines to control both innate and adaptive immunity. Because of their very low frequency in the...
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T Cell's Sense of Self: a Role of Self-Recognition in Shaping Functional Competence of Naïve T Cells

Kim HO, Cho JH

Post-thymic naïve T cells constitute a key cellular arm of adaptive immunity, with a well-known characteristic of the specificity and robustness of responses to cognate foreign antigens which is presented...
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The Anti-apoptotic Effect of Ghrelin on Restraint Stress-Induced Thymus Atrophy in Mice

Lee JH, Kim TJ, Kim JW, Yoon JS, Kim HS, Lee KM

Thymic atrophy is a complication that results from exposure to many environmental stressors, disease treatments, and microbial challenges. Such acute stress-associated thymic loss can have a dramatic impact on the...
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Selection of Thymocytes Expressing Transgenic TCR Specific for a Minor Histocompatibility Antigen, H60

Ju JM, Kim MB, Ryu SJ, Kim JY, Chang J, Choi EY

Minor histocompatibility antigens are MHC-bound peptides and contribute to the generation of allo-responses after allogeneic transplantation. H60 is a dominant minor H antigen that induces a strong CD8 T-cell response...
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The Role of Dendritic Cells in Central Tolerance

Oh J, Shin JS

Dendritic cells (DCs) play a significant role in establishing self-tolerance through their ability to present self-antigens to developing T cells in the thymus. DCs are predominantly localized in the medullary...
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Analyses of the TCR repertoire of MHC class II-restricted innate CD4+ T cells

Kang BH, Min HS, Lee YJ, Choi B, Kim EJ, Lee J, Kim JR, Cho KH, Kim TJ, Jung KC, Park SH

Analysis of the T-cell receptor (TCR) repertoire of innate CD4+ T cells selected by major histocompatibility complex (MHC) class II-dependent thymocyte-thymocyte (T-T) interaction (T-T CD4+ T cells) is essential for...
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Methylmercury Exposure and Health Effects

Hong YS, Kim YM, Lee KE

  • KMID: 1499657
  • J Prev Med Public Health.
  • 2012 Nov;45(6):353-363.
Methylmercury is a hazardous substance that is of interest with regard to environmental health, as inorganic mercury circulating in the general environment is dissolved into freshwater and seawater, condensed through...
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T Cell Receptor Signaling That Regulates the Development of Intrathymic Natural Regulatory T Cells

Song KD, Hwang S, Yun CH

T cell receptor (TCR) signaling plays a critical role in T cell development, survival and differentiation. In the thymus, quantitative and/or qualitative differences in TCR signaling determine the fate of...
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Expression of IL-17A during Thymus Regeneration in the Rat

Choi HJ, Lee HW, Park JH, Oh SO, Baek SY, Kim BS, Yoon S

  • KMID: 1449621
  • Korean J Phys Anthropol.
  • 2011 Sep;24(3):141-154.
IL-17A is a pro-inflammatroy cytokine secreted by activated T cells. The IL-17 family consist of IL-17A, IL-17B, IL-17C, IL-17D, IL-17E and IL-17F. IL-17A and IL-17F are produced primarily in activated...
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Characterization of Monoclonal Antibodies against Human Leukocyte Common Antigen (CD45)

Shin HM, Cho WD, Lee GK, Lee SH, Lee KM, Ji GY, Yoon SS, Koo JH, Lee HC, Lee KH, Song HG

BACKGROUND: The leukocyte common antigen (CD45) is a transmembrane-type protein tyrosine phosphatase that has five isoforms. METHODS: We generated seven murine mAbs against human CD45 by injecting cells from different origins,...
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Polybrominated Diphenyl Ethers Orally Administration to Mice Were Tansferred to Offspring during Gestation and Lactation with Disruptions on the Immune System

Hong SK, Sohn KH, Kim IY, Lee JK, Ju JH, Kim JH, Lim CH, Han BS, Jung HC, Lee JY, Park KL

BACKGROUND: The present study was undertaken to examine the immunological effects of pentabrominated diphenyl ether (penta-BDE) and decabrominated diphenyl ether (deca-BDE) on the immune system of the dams and the...
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A Case of Successful Treatment of Cutaneous Aspergillosis with Voriconazole at the Low Cyclosporine Trough Level in a Renal Transplant

Park SJ

Aspergillosis is a serious infectious complication with high mortality in transplant recipients. Voriconazole is a broad spectrum triazole antifungal agent, but it has a drug-drug interaction with immunosuppressants. Herein we...
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Expression of the p75NTR Neurotrophin Receptor in the Thymic Medullary Epithelial Cells and Interdigitating Dendritic Cells during Rat Thymus Regeneration Following Acute Thymic Involution

Shim NR, Kim HJ, Oh SO, Baek SY, Kim BS, Kim JB, Yoon S

  • KMID: 2092957
  • Korean J Anat.
  • 2009 Jun;42(2):105-114.
The existence of a functional link between the nervous and immune systems has been well established. The present study was to characterize the expression of p75NTR during thymus regeneration from...
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Immune Cell Activation and Co-X-irradiation Effect of Eleutherococcus senticosus Maxim Root

Kwon HC, Park JS, Choi DS

  • KMID: 2097236
  • J Korean Soc Ther Radiol Oncol.
  • 2007 Sep;25(3):185-191.
PURPOSE: This study was performed to investigate the effects of immune cell activation and the antitumor effect for the combination of treatment with X-irradiation and Eleutherococcus senticosus Maxim Root (ESMR)...
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Expression of CD70 during Thymus Regeneration in the Rat

Kim SM, Kim MN, Lee HW, Kim BS, Kim JB, Yoon S

  • KMID: 1510221
  • Korean J Anat.
  • 2006 Dec;39(6):471-481.
The thymus is the central lymphoid organ for development of bone marrow-derived precursor cells into mature T-cells. The thymic stroma provides the specialized microenvironment for the proliferation, differentiation, and maturation...
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The Studies on the Factors Related to Normal Hair Growth During Postnatal Growth Periods in C57BL/6N, Hairless and Alopecia Areata Mice Model

Lee MW, Oh CH, Kwon J, Song CH, Lee CH

  • KMID: 2283200
  • Korean J Phys Anthropol.
  • 2005 Mar;18(1):13-27.
We have examined the factors related to hair growth regulation during postnatal growth periods in C57BL/6N, hairless and alopecia areata mice model. We first studied the number, localization and granulation...
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CD24 Expression in Gastric Adenocarcinoma Is Associated with Tumor Invasiveness

Jung KC, Seo JN, Kim TW, Choi YM, Oh KI, Song HH, Shin HS, Park YE

  • KMID: 2277693
  • Korean J Pathol.
  • 2004 Dec;38(6):388-393.
BACKGROUND: CD24, also referred to as the heat stable antigen in mice, is a glycosyl phosphatidylinositol- linked glycoprotein expressed by thymocytes, B cells, neutrophils and immature neuronal cells. It has...
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Antigen Nonspecific Death of Immature Thymocytes by Corticosteroids and TNF

Oh K, Surh CD, Cho J, Lee DS

BACKGROUND: In the thymus, developing thymocytes continually interact with thymic epithelial cell components. Self MHC restriction of mature T cells are imposed in the thymus through interaction of immature double...
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Ultrastructure of Different Types of Thymic Epithelial Cells in the Rat Thymus

Kim BS, Lee KH, Lee HW, Kim JB, Kim SI, Yoon S

  • KMID: 1610766
  • Korean J Anat.
  • 2003 Aug;36(4):309-322.
Thymic epithelial cells constitute a major component of the thymic microenvironment. The thymus is involved in the regulation of the proliferation, maturation and differentiation of thymocytes. There is some controversy...
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The Differential Staging of Murine Thymic Lymphoma Cell Lines, Scid.adh, R1.1 and EL-4

Chae JS, Kim HJ, Park WS, Bae Y, Jung KC

BACKGROUND: Scid.adh is a recently developed murine thymic lymphoma cell line, which has been used as in vitro model for the study of double negative stage III thymocytes. In this...
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