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In vitro cytotoxicity of a novel platinum(II) coordination complex containing diaminocyclohexane and dichloropropane

Rho YS, Chang SG, Lee WT, Jung JC

  • Korean J Physiol Pharmacol.
  • 2001 Aug;5(4):359-366.
We have synthesized a novel platinum(II) coordination complex containing cis-1,2-diaminocyclohexane (DACH) as a carrier ligand and 1,3-dichloropropane (DCP) as a leaving group. A new series of (Pt(cis-DACH)(DCP))(PC) was evaluated for its cytotoxic: activity...
Histopathologic study and expression of TGF-beta1 of choanal polyp

Ahn BH

  • Korean J Physiol Pharmacol.
  • 2001 Aug;5(4):353-357.
The pathogenesis of the nasal polyp is multifactorial and choanal polyps can be defined by its origin of genesis: antrochoanal (maxillochoanal), ethmochoanal and sphenochoanal polyp. Transforming growth factor-beta (TGF-beta) has various biologic activities,...
Lipopolysaccharide inhibits proliferation of the cultured vascular smooth muscle cells by stimulating inducible nitric oxide synthase and subsequent activation of guanylate cyclase

Choi HC, Lee SG, Kim JH, Kim JY, Sohn UD, Ha JH, Lee KY, Kim WJ

  • Korean J Physiol Pharmacol.
  • 2001 Aug;5(4):343-351.
This study was undertaken to investigate the mechanism of lipopolysaccharide (LPS) and nitric oxide (NO) as a regulator of vascular smooth muscle cell (VSMC) proliferation. VSMC was primarily cultured from rat aorta and...
The protective effect of melatonin administration against adriamycin-induced cardiotoxicity in rats

Han J, Kim C, Kim N, Park J, Yang Y, Kim E

  • Korean J Physiol Pharmacol.
  • 2001 Aug;5(4):333-342.
Adriamycin is a commonly used chemotherapeutic agent for cancer, including acute leukemia, lymphoma, and a number of solid human tumors. However, recent studies have recognized severe cardiotoxicity after an acute dose, which are...
Protective effect of rutin on splanchnic injury following ischemia and reperfusion in rats

Lee HM, Jang YY, Song JH, Kim KJ, Lim IJ, Shin YK

  • Korean J Physiol Pharmacol.
  • 2001 Aug;5(4):323-331.
A splanchic artery occlusion for 90 min followed by reperfusion of the mesenteric circulation resulted in a severe form of circulatory shock characterized by endothelial dysfunction, severe hypotension, marked intestinal tissue injury, and...
Inhibitory effect of quercetin and desferrioxamine in rat reflux esophagitis

Song HJ, Kil BJ, Kim IW, Min YS, Kim DS, Sohn UD

  • Korean J Physiol Pharmacol.
  • 2001 Aug;5(4):315-321.
This study was aimed to evaluate the effects of quercetin and desferrioxamine on the development of the reflux esophagitis induced surgically, on gastric secretion and on lipid peroxidation which is a marker of...
Decreased expression of aquaporin-2 water channels in the kidney in rats treated with reserpine

Lee JU, Oh YW, Kim S

  • Korean J Physiol Pharmacol.
  • 2001 Aug;5(4):307-313.
Whether there exists a Sympathetic neural mechanism regulating the expression of aquaporin (AQP) water channels in the kidney was investigated. Male Sprague-Dawley rats were treated with reserpine (1 mg/kg, IP), and the expression...
Regulation of phosphorylated cAMP response element-binding protein, Fos-related antigen and FosB expression by dopamine agonists in rat striatum

Choe ES, Kim JY

  • Korean J Physiol Pharmacol.
  • 2001 Aug;5(4):299-305.
Activation of D1-like dopamine receptors by psychostimulants, such as amphetamine, upregulates the expression of immediate early gene and opioid peptide gene in the striatum. The genomic changes are regulated by phosphorylated transcription factors...
G protein-coupled receptor signaling in gastrointestinal smooth muscle

Sohn UD, Kim DS, Murthy KS

  • Korean J Physiol Pharmacol.
  • 2001 Aug;5(4):287-297.
Contraction of smooth muscle is initiated by an increase in cytosolic Ca2+ leading to activation of Ca2+/calmodulin-dependnet myosin light chain (MLC) kinase and phosphorylation of MLC. The types of contraction and signaling mechanisms...

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