- Role of Post-translational Modification of Silent Mating Type Information Regulator 2 Homolog 1 in Cancer and Other Disorders
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Lee YH, Kim SJ, Surh YJ
- KMID: 2533965
- J Cancer Prev.
- 2022 Sep;27(3):157-169.
- doi: 10.15430/JCP.2022.27.3.157
Silent mating type information regulator 2 homolog 1 (SIRT1), an NAD + -dependent histone/protein deacetylase, has multifarious physiological roles in development, metabolic regulation, and stress response. Thus, its abnormal expression... -
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- Nuclear Localization of Fibroblast Growth Factor Receptor 1 in Breast Cancer Cells Interacting with Cancer Associated Fibroblasts
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Suh J, Kim DH, Kim SJ, Cho NC, Lee YH, Jang JH, Surh YJ
- KMID: 2528095
- J Cancer Prev.
- 2022 Mar;27(1):68-76.
- doi: 10.15430/JCP.2022.27.1.68
Cancer-associated fibroblasts (CAFs) represent a major component of the tumor microenvironment and interplay with cancer cells by secreting cytokines, growth factors and extracellular matrix proteins. When estrogen receptor-negative breast cancer... -
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- Non-canonical vs. Canonical Functions of Heme Oxygenase-1 in Cancer
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Jagadeesh ASV, Fang X, Kim SH, Guillen-Quispe YN, Zheng J, Surh YJ, Kim SJ
- KMID: 2528081
- J Cancer Prev.
- 2022 Mar;27(1):7-15.
- doi: 10.15430/JCP.2022.27.1.7
Heme oxygenase-1 (HO-1) is a critical stress-responsive enzyme that has antioxidant and anti-inflammatory functions. HO-1 catalyzes heme degradation, which gives rise to the formation of carbon monoxide (CO), biliverdin, and... -
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- Potential Role of Heme Oxygenase-1 in the Resolution of Experimentally Induced Colitis through Regulation of Macrophage Polarization
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Gwak SY, Kim SJ, Park J, Kim SH, Joe Y, Lee HN, Kim W, Muna IA, Na HK, Chung HT, Surh YJ
- KMID: 2526998
- Gut Liver.
- 2022 Mar;16(2):246-258.
- doi: 10.5009/gnl210058
Background/Aims: Heme oxygenase-1 (HO-1) plays a central role in cellular defense against inflammatory insults, and its induction in macrophages potentiates their efferocytic activity. In this study, we explored the potential... -
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- STAT3 as a Potential Target for Tumor Suppressive Effects of 15-Deoxy-Δ12,14-prostaglandin J2 in Triple Negative Breast Cancer
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Kim SJ, Cho NC, Hahn YI, Kim SH, Fang X, Surh YJ
- KMID: 2521109
- J Cancer Prev.
- 2021 Sep;26(3):207-217.
- doi: 10.15430/JCP.2021.26.3.207
STAT3 plays a prominent role in proliferation and survival of tumor cells. Thus, STAT3 has been considered to be a prime target for development of anti-cancer therapeutics. The electrophilic cyclopentenone... -
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- Protective Effects of Silibinin on Helicobacter pyloriinduced Gastritis: NF-κB and STAT3 as Potential Targets
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Cho K, Lee HG, Piao JY, Kim SJ, Na HK, Surh YJ
- KMID: 2517363
- J Cancer Prev.
- 2021 Jun;26(2):118-127.
- doi: 10.15430/JCP.2021.26.2.118
More than half of the world’s populations are considered to be infected by Helicobacter pylori. It causes a chronic inflammation of the stomach, which is implicated in the pathogenesis of... -
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- Heregulin-β1 Activates NF-E2-related Factor 2 and Induces Manganese Superoxide Dismutase Expression in Human Breast Cancer Cells via Protein Kinase B and Extracellular Signal-regulated Protein Kinase Signaling Pathways
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Park JY, Saeidi S, Kim EH, Kim DH, Na HK, Keum JS, Surh YJ
- KMID: 2514695
- J Cancer Prev.
- 2021 Mar;26(1):54-63.
- doi: 10.15430/JCP.2021.26.1.54
Heregulin-β1, a ligand of ErbB-2 and ErbB-3/4 receptors, has been reported to potentiate oncogenicity and metastatic potential of breast cancer cells. In the present work, treatment of human mammary cancer... -
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- Interaction between Peptidyl-prolyl Cis-trans Isomerase NIMA-interacting 1 and GTP-H-Ras: Implications for Aggressiveness of Human Mammary Epithelial Cells and Drug Resistance
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Saeidi S, Joo S, Kim SJ, Jagadeesh ASV, Surh YJ
- KMID: 2510153
- J Cancer Prev.
- 2020 Dec;25(4):234-243.
- doi: 10.15430/JCP.2020.25.4.234
Aberrant activation of Ras has been implicated in aggressiveness of breast cancer. Among Ras isoforms (H-, K-, and N-), H-Ras has been known to be primarily responsible for invasion and... -
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- 15-Deoxy-Δ12,14 -prostaglandin J2 Induces Epithelial-tomesenchymal Transition in Human Breast Cancer Cells and Promotes Fibroblast Activation
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Choi 1 J, Suh JY, Kim DH, Na HK, Surh YJ
- KMID: 2506970
- J Cancer Prev.
- 2020 Sep;25(3):152-163.
- doi: 10.15430/JCP.2020.25.3.152
In inflammation-associated carcinogenesis, COX-2 is markedly overexpressed, resulting in accumulation of various prostaglandins. 15-deoxy-Δ 12,14 -prostaglandin J 2 (15d-PGJ2 ) is one of the terminal products of COX-2-catalyzed... -
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- 15-Deoxy-Δ12,14-prostaglandin J2 Induces Apoptosis in Ha-ras-transformed Human Breast Epithelial Cells by Targeting IκB kinase–NF-κB Signaling
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Na HK, Yang H, Surh YJ
- KMID: 2503566
- J Cancer Prev.
- 2020 Jun;25(2):100-110.
- doi: 10.15430/JCP.2020.25.2.100
15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2), an endogenous ligand for PPARγ, has differential effects on cancer cell proliferation and survival depending on the dose and the type of cells. In the present study, we... -
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- Effects of Genetic and Pharmacologic Inhibition of COX-2 on Colitis-associated Carcinogenesis in Mice
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Lee JS, Kim HS, Hahm KB, Surh YJ
- KMID: 2505224
- J Cancer Prev.
- 2020 Mar;25(1):27-37.
- doi: 10.15430/JCP.2020.25.1.27
COX-2 has been inappropriately overexpressed in various human malignancies, and is considered as one of the representative targetsfor the chemoprevention of inflammation-associated cancer. In order to assess the role of... -
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- 17β-Estradiol reduces inflammation and modulates antioxidant enzymes in colonic epithelial cells
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Son HJ, Kim N, Song CH, Lee SM, Lee HN, Surh YJ
- KMID: 2502017
- Korean J Intern Med.
- 2020 Mar;35(2):310-319.
- doi: 10.3904/kjim.2018.098
Background/Aims: Estrogen is known to have protective effect in colorectal cancer development. The aims of this study are to investigate whether estradiol treatment reduces inflammation in CCD841CoN, a female human... -
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- Genistein Inhibits Proliferation of BRCA1 Mutated Breast Cancer Cells: The GPR30-Akt Axis as a Potential Target
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Kim GY, Suh J, Jang JH, Kim DH, Park OJ, Park SK, Surh YJ
- KMID: 2468809
- J Cancer Prev.
- 2019 Dec;24(4):197-207.
- doi: 10.15430/JCP.2019.24.4.197
BACKGROUND: BRCA1 mutated breast cancer cells exhibit the elevated cell proliferation and the higher metastatic potential. G protein-coupled receptor 30 (GPR30) has been shown to regulate growth of hormonally responsive... -
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- Baicalein Inhibits Dextran Sulfate Sodium-induced Mouse Colitis
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Zhong X, Surh YJ, Do SG, Shin E, Shim KS, Lee CK, Na HK
- KMID: 2454672
- J Cancer Prev.
- 2019 Jun;24(2):129-138.
- doi: 10.15430/JCP.2019.24.2.129
BACKGROUND: Baicalein is a bioactive flavone that is originally extracted from the root of Scutellaria baicalensis Georgi. This plant has long served as Chinese herbal medicine in the management of... -
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- Ajoene, a Major Organosulfide Found in Crushed Garlic, Induces NAD(P)H:quinone Oxidoreductase Expression Through Nuclear Factor E2-related Factor-2 Activation in Human Breast Epithelial Cells
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Cho SJ, Ryu JH, Surh YJ
- KMID: 2454670
- J Cancer Prev.
- 2019 Jun;24(2):112-122.
- doi: 10.15430/JCP.2019.24.2.112
BACKGROUND: NAD(P)H:quinone oxidoreductase-1 (NQO1) is a widely-distributed flavin adenine dinucleotide-dependent flavoprotein that promotes obligatory 2-electron reductions of quinones, quinoneimines, nitroaromatics, and azo dyes. This reduces quinone levels and thereby minimizes... -
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- Effect of Estradiol in an Azoxymethane/Dextran Sulfate Sodium-Treated Mouse Model of Colorectal Cancer: Implication for Sex Difference in Colorectal Cancer Development
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Son HJ, Sohn SH, Kim N, Lee HN, Lee SM, Nam RH, Park JH, Song CH, Shin E, Na HY, Kim JS, Lee DH, Surh YJ
- KMID: 2464410
- Cancer Res Treat.
- 2019 Apr;51(2):632-648.
- doi: 10.4143/crt.2018.060
PURPOSE: This study demonstrates that estradiol downregulates inflammation and inhibits colorectal cancer (CRC) development in azoxymethane/dextran sulfate sodium (AOM/DSS) mouse model. MATERIALS AND METHODS: AOM/DSS-treated male and female mice were sacrificed... -
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- Effects of 17β-Estradiol on Colonic Permeability and Inflammation in an Azoxymethane/Dextran Sulfate Sodium-Induced Colitis Mouse Model
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Song CH, Kim N, Sohn SH, Lee SM, Nam RH, Na HY, Lee DH, Surh YJ
- KMID: 2427459
- Gut Liver.
- 2018 Nov;12(6):682-693.
- doi: 10.5009/gnl18221
BACKGROUND/AIMS: Intestinal barrier dysfunction is a hallmark of inflammatory bowel diseases (IBDs) such as ulcerative colitis. This dysfunction is caused by increased permeability and the loss of tight junctions in... -
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- Comparative Effects of Curcumin and Tetrahydrocurcumin on Dextran Sulfate Sodium-induced Colitis and Inflammatory Signaling in Mice
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Yang JY, Zhong X, Kim SJ, Kim DH, Kim HS, Lee JS, Yum HW, Lee J, Na HK, Surh YJ
- KMID: 2416948
- J Cancer Prev.
- 2018 Mar;23(1):18-24.
- doi: 10.15430/JCP.2018.23.1.18
BACKGROUND: Curcumin, a yellow ingredient of turmeric (Curcuma longa Linn, Zingiberaceae), has long been used in traditional folk medicine in the management of inflammatory disorders. Although curcumin has been reported... -
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- Açaà Berries Inhibit Colon Tumorigenesis in Azoxymethane/Dextran Sulfate Sodium-Treated Mice
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Choi YJ, Choi YJ, Kim N, Nam RH, Lee S, Lee HS, Lee HN, Surh YJ, Lee DH
- KMID: 2412191
- Gut Liver.
- 2017 Mar;11(2):243-252.
- doi: 10.5009/gnl16068
BACKGROUND/AIMS: The aim of this study was to investigate the protective effect of açaà against azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced colorectal cancer development. METHODS: The effect of açaà on tumorigenesis was... -
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- Resveratrol Inhibits IL-6-Induced Transcriptional Activity of AR and STAT3 in Human Prostate Cancer LNCaP-FGC Cells
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Lee MH, Kundu JK, Keum YS, Cho YY, Surh YJ, Choi BY
- KMID: 2380320
- Biomol Ther.
- 2014 Sep;22(5):426-430.
- doi: 10.4062/biomolther.2014.061
Prostate cancer is the most frequently diagnosed cancer. Although prostate tumors respond to androgen ablation therapy at an early stage, they often acquire the potential of androgen-independent growth. Elevated transcriptional... -
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