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Serum albumin is the strongest predictor of anti-tumor necrosis factor nonresponse in inflammatory bowel disease in resource-constrained regions lacking therapeutic drug monitoring

Kumar P, Vuyyuru SK, Das P, Kante B, Ranjan MK, Thomas DM, Mundhra S, Sahu P, Venigalla PM, Jain S, Goyal S, Golla R, Virmani S, Singh MK, Sachdeva K, Sharma R, Dash NR, Makharia G, Kedia S, Ahuja V

Background/Aims: Evidence on predictors of primary nonresponse (PNR), and secondary loss of response (SLR) to anti-tumor necrosis factor (anti-TNF) agents in inflammatory bowel disease is scarce from Asia. We evaluated...
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The diagnostic accuracy of ultrasonography over manual aspiration for gastric reserve volume estimation in critically ill patients

Sharma R, Dogra RK, Pathania J, Sharma A

Background: Although gastric reserve volume (GRV) is a surrogate marker for gastrointestinal dysfunction and feeding intolerance. There is ambiguity in its estimation in most of the international guidelines due to...
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Effect of preexisting human leukocyte antigen donor-specific antibodies especially human leukocyte antigen-DQ on kidney transplant outcome

Mehrotra S, Sharma R, Kapoor R, Agarwal M, Kumar A, Bhaskar V

Background: Luminex based anti-human leukocyte antigen (HLA) antibody assay to detect donor-specific antibodies (DSA) sin-gle antigen bead (SAB) assay a useful tool for pretransplant immunologic risk evaluation. Methods: One-hundred-nineteen prospective kidney...
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An Insight of Nanomaterials in Tissue Engineering from Fabrication to Applications

Sharma R, Kumar S, B, Gupta A, Dheer N, Jain P, Singh P, Kumar V

Tissue engineering is a research domain that deals with the growth of various kinds of tissues with the help of synthetic composites. With the culmination of nanotechnology and bioengineering, tissue...
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Sperm Morphology Assessment in the Era of Intracytoplasmic Sperm Injection: Reliable Results Require Focus on Standardization, Quality Control, and Training

Agarwal A, Sharma R, Gupta S, Finelli R, Parekh N, Selvam MKP, Henkel R, Durairajanayagam D, Pompeu C, Madani S, Belo A, Singh N, Covarrubias S, Darbandi S, Sadeghi R, Darbandi M, Vogiatzi P, Boitrelle F, Simopoulou M, Saleh R, Arafa M, Majzoub A, Kandil H, Zini A, Ko E, Alvarez JG, Martinez M, Ramsay J, Jindal S, Busetto GM, Sallam H, Maldonado I, Anagnostopoulou C, Alves MG, Sengupta P, Gilany K, Evenson DP, Lewis SE, Gosalvez J, Ambar RF, Shah R

Semen analysis is the first, and frequently, the only step in the evaluation of male fertility. Although the laboratory procedures are conducted according to the World Health Organization (WHO) guidelines,...
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Antisperm Antibody Testing: A Comprehensive Review of Its Role in the Management of Immunological Male Infertility and Results of a Global Survey of Clinical Practices

Gupta S, Sharma R, Agarwal A, Boitrelle F, Finelli R, Farkouh A, Saleh R, Abdel-Meguid TAA, Gül M, Zilaitiene B, Ko E, Rambhatla A, Zini A, Leisegang K, Kuroda S, Henkel R, Cannarella R, Palani A, Cho CL, Ho CC, Zylbersztejn DS, Pescatori E, Chung E, Dimitriadis F, Pinggera GM, Busetto GM, Balercia G, Salvio G, Colpi GM, Çeker G, Taniguchi H, Kandil H, Park HJ, Rosas IM, Rosette Jdl, Cardoso JPG, Ramsay J, Alvarez J, Corral Molina JM, Khalafalla K, Bowa K, Tremellen K, Evgeni E, Rocco L, Rodriguez Peña MG, Sabbaghian M, Martinez M, Arafa M, Al-Marhoon MS, Tadros N, Garrido N, Rajmil O, Sengupta P, Vogiatzi P, Kavoussi P, Birowo P, Kosgi R, Bani-Hani S, Micic S, Parekattil S, Jindal S, Le TV, Mostafa T, Toprak T, Morimoto Y, Malhotra V, Aghamajidi A, Durairajanayagam D, Shah R

Antisperm antibodies (ASA), as a cause of male infertility, have been detected in infertile males as early as 1954. Multiple causes of ASA production have been identified, and they are...
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Renal Replacement Lipomatosis: A Rare and Often Ignored Entity

Sharma R, Khera S, Singh M, Sarangi SS, Begam I

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Efficacy and tolerability of hyperbaric oxygen therapy in small bowel stricturing Crohn’s disease: a pilot study

Kante B, Sahu P, Kedia S, Vuyyuru SK, Soni K, Singhal M, Sharma R, Makharia G, Ahuja V

Background/Aims: Existing therapeutic options for complicated Crohn’s disease (CD) like biologics and surgery are limited by inadequate long-term efficacy, cost, and adverse effects. Tissue hypoxia is important in CD pathogenesis...
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Relevance of Leukocytospermia and Semen Culture and Its True Place in Diagnosing and Treating Male Infertility

Sharma R, Gupta S, Agarwal A, Henkel R, Finelli R, Parekh N, Saleh R, Arafa M, Ko E, Zini A, Tadros N, Shah R, Ambar RF, Elbardisi H, Sengupta P, Martinez M, Boitrelle F, Simopoulou M, Vogiatzi P, Gosalvez J, Kavoussi P, Kandil H, Palani A, Peña MR, Rajmil O, Busetto GM, Anagnostopoulou C, Micic S, Alves MG, Rocco L, Mostafa T, Alvarez JG, Jindal S, Sallam HN, Rosas IM, Lewis SE, AlSaid S, Altan M, Park HJ, Ramsay J, Parekattil S, Sabbaghian M, Tremellen K, Khalafalla K, Durairajanayagam D, Colpi GM

The current WHO 2010 manual for human semen analysis defines leukocytospermia as the presence of peroxidase-positive leukocytes at a concentration >1×10 6 /mL of semen. Granular leukocytes when activated are...
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A Comprehensive Guide to Sperm Recovery in Infertile Men with Retrograde Ejaculation

Gupta S, Sharma R, Agarwal A, Parekh N, Finelli R, Shah R, Kandil H, Saleh R, Arafa M, Ko E, Simopoulou M, Zini A, Rajmil O, Kavoussi P, Singh K, Ambar RF, Elbardisi H, Sengupta P, Martinez M, Boitrelle F, Alves MG, Khalafalla K, Roychoudhury S, Busetto GM, Gosalvez J, Tadros N, Palani A, Rodriguez MG, Anagnostopoulou C, Micic S, Rocco L, Mostafa T, Alvarez JG, Jindal S, Sallam H, Rosas IM, Lewis SEM, AlSaid S, Altan M, Park HJ, Ramsay J, Parekattil S, Sabbaghian M, Tremellen K, Vogiatzi P, Sadighi Gilani MA, Evenson DP, Colpi GM

Retrograde ejaculation (RE) is a condition defined as the backward flow of the semen during ejaculation, and when present can result in male infertility. RE may be partial or complete,...
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Addition of computed tomography chest increases the diagnosis rate in patients with suspected intestinal tuberculosis

Kedia S, Sharma R, Vuyyuru SK, Madhu D, Sahu P, Kante B, Das P, Goyal A, Madan K, Makharia G, Ahuja V

Background/Aims: Intestinal tuberculosis (ITB) is difficult to diagnose due to poor sensitivity of definitive diagnostic tests. ITB may be associated with concomitant pulmonary tuberculosis (PTB) which may remain undetected on...
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Standardized Laboratory Procedures, Quality Control and Quality Assurance Are Key Requirements for Accurate Semen Analysis in the Evaluation of Infertile Male

Agarwal A, Sharma R, Gupta S, Finelli R, Parekh N, Selvam MKP, Pompeu CP, Madani S, Belo A, Darbandi M, Singh N, Darbandi S, Covarrubias S, Sadeghi R, Arafa M, Majzoub A, Caraballo M, Giroski A, McNulty K, Durairajanayagam D, Henkel R

Semen analysis is a basic test for evaluating male fertility potential, as it plays an essential role in driving the future management and treatment of infertility in couples. Manual semen...
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A Web-Based Global Educational Model for Training in Semen Analysis during the COVID-19 Pandemic

Agarwal A, Finelli R, Durairajanayagam D, Leisegang K, Sharma R, Gupta S, Singh N, Belo A, Darbandi M, Madani S, Covarrubias S, Darbandi S, Sadeghi R, Pompeu C, Boitrelle F, Kandil H, Saleh R, Arafa M, Vogiatzi P, Rosas IM, Anagnostopoulou C, Chockalingam A, Wirka KA, Sallam HN, Shah R, Henkel R

Purpose: In response to the COVID-19 pandemic, the American Center for Reproductive Medicine (ACRM) transitioned its annual training in assisted reproductive technology (ART) from a hands-on, laboratory-based training course to...
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High mucosal cytomegalovirus DNA helps predict adverse short-term outcome in acute severe ulcerative colitis

Jain S, Namdeo D, Sahu P, Kedia S, Sahni P, Das P, Sharma R, Gupta V, Makharia G, Dar L, Travis SP, Ahuja V

Background/Aims: Predictors of short-term outcome of intravenous (IV) steroid therapy in acute severe ulcerative colitis (ASUC) have been well described, but the impact of cytomegalovirus (CMV) infection as a predictor...
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Scrutiny of COVID-19 response strategies among severely affected European nations

Stephen S, Issac A, Radhakrishnan RV, Jacob J, Vijay V, Jose S, Azhar S, Nair AS, Krishnan N, Sharma R, Dhandapani M

Although the health care systems in Europe are considered the global benchmark, European nations were severely affected by the coronavirus disease 2019 (COVID-19) pandemic. This manuscript aimed to examine the...
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Comparative Performance of Line Probe Assay (Version 2) and Xpert MTB/RIF Assay for Early Diagnosis of Rifampicin-Resistant Pulmonary Tuberculosis

Yadav RN, Kumar Singh B, Sharma R, Chaubey J, Sinha S, Jorwal P

Background: The emergence of drug-resistant tuberculosis (TB), is a major menace to cast off TB worldwide. Line probe assay (LPA; GenoType MTBDRplus ver. 2) and Xpert MTB/RIF assays are two...
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Efficacy and tolerability of exclusive enteral nutrition in adult patients with complicated Crohn’s disease

Sharma S, Gupta A, Kedia S, Agarwal S, Singh N, Goyal S, Jain S, Gupta V, Sahu P, Vuyyuru SK, Kante B, Sharma R, Panwar R, Sahni P, Makharia G, Ahuja V

Background/Aims: Exclusive enteral nutrition (EEN), an established modality for pediatric Crohn’s disease (CD) is seldomly utilized in adults. The present study reports the outcome of EEN in adult CD patients...
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Perinatal outcome and possible vertical transmission of coronavirus disease 2019: experience from North India

Sharma R, Seth S, Sharma R, Yadav S, Mishra P, Mukhopadhyay S

Background: The consequences of severe acute respiratory syndrome corona virus 2 on mother and fetus remain unknown due to a lack of robust evidence from prospective studies. Purpose: This study evaluated...
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Best Practice Guidelines for Andrology Laboratory Services during COVID-19 Crisis: Cleveland Clinic’s Experience

Agarwal A, Sharma R, Gupta S, Caraballo M, Finelli R, Madani S, Panner Selvam MK

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Protein Fingerprinting of Seminal Plasma Reveals Dysregulation of Exosome-Associated Proteins in Infertile Men with Unilateral Varicocele

Selvam MKP, Agarwal A, Sharma R, Samanta L, Gupta S, Dias TR, Martins AD

Purpose: Aberrant expression of seminal plasma proteins are associated with altered homeostasis that may affect the fertilizing ability of spermatozoa. However, the precise roles of seminal exosomes on sperm function...
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