- The Role of Serotonin in Ventricular Repolarization in Pregnant Mice
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Cui S, Park H, Park H, Mun D, Lee SH, Kim H, Yun N, Kim H, Kim M, Pak HN, Lee MH, Joung B
- KMID: 2418792
- Yonsei Med J.
- 2018 Mar;59(2):279-286.
- doi: 10.3349/ymj.2018.59.2.279
PURPOSE: The mechanisms underlying repolarization abnormalities during pregnancy are not fully understood. Although maternal serotonin (5-hydroxytryptamine, 5-HT) production is an important determinant for normal fetal development in mice, its role... -
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- Combination of nefopam and remifentanil is more effective to reduce rocuronium-induced withdrawal response compared with remifentanil alone: a prospective, double-blinded, randomized control study
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Jung KT, Kim SH, So KY, Moon HM
- KMID: 2436056
- Anesth Pain Med.
- 2018 Jan;13(1):53-60.
- doi: 10.17085/apm.2018.13.1.53
BACKGROUND: We investigated the effect of combination of nefopam and remifentanil under the hypothesis that nefopam would effectively prevent rocuronium-induced withdrawal response by blocking serotonin receptors and providing a synergistic... -
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- Morphologic changes in the spinal cord following intrathecal palonosetron-HCl injection in rats
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Yoo SH, Chung JH, Seo Y, Choi MK, Choi WK, Kim JB
- KMID: 2388836
- Anesth Pain Med.
- 2017 Jul;12(3):224-229.
- doi: 10.17085/apm.2017.12.3.224
BACKGROUND: Intravenous palonosetron-HCl, a second-generation antagonist of selective serotonin type 3 (5-HT3) receptors, can prevent chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV). 5-HT3 receptors are abundant... -
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- Serotonin reuptake inhibitors and bone health: A review of clinical studies and plausible mechanisms
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Wadhwa R, Kumar M, Talegaonkar S, Vohora D
- KMID: 2387462
- Osteoporos Sarcopenia.
- 2017 Jun;3(2):75-81.
- doi: 10.1016/j.afos.2017.05.002
Selective serotonin reuptake inhibitors (SSRIs) are currently the treatment of choice in depression and constitute major portion of prescription in depressive patients. The role of serotonin receptors in bone is... -
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- Ketanserin and Naftopidil Enhance the Potentiating Effect of Alpha-Methyl-Serotonin on the Neurally-Induced Contraction of Human Isolated Urinary Bladder Muscle Strips
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Hattori T, Lluel P, Rouget C, Rekik M, Yoshiyama
- KMID: 2375590
- Int Neurourol J.
- 2017 Mar;21(1):20-28.
- doi: 10.5213/inj.1732758.379
PURPOSE: The aim of this study was to assess the potential involvement of a specific subtype of 5-hydroxytryptamine (5-HT), 5HT(2) receptors in neurally-induced contractions of the human detrusor. METHODS: Contractile responses... -
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- Lamotrigine, an antiepileptic drug, inhibits 5-HT₃ receptor currents in NCB-20 neuroblastoma cells
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Kim KJ, Jeun SH, Sung KW
- KMID: 2371035
- Korean J Physiol Pharmacol.
- 2017 Mar;21(2):169-177.
- doi: 10.4196/kjpp.2017.21.2.169
Lamotrigine is an antiepileptic drug widely used to treat epileptic seizures. Using whole-cell voltage clamp recordings in combination with a fast drug application approach, we investigated the effects of lamotrigine... -
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- Hippocampal serotonin-2A receptor-immunoreactive neurons density increases after testosterone therapy in the gonadectomized male mice
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Nikmahzar , Jahanshahi M, Ghaemi A, Naseri GR, Moharreri , Lotfinia A
- KMID: 2365556
- Anat Cell Biol.
- 2016 Dec;49(4):259-272.
- doi: 10.5115/acb.2016.49.4.259
The change of steroid levels may also exert different modulatory effects on the number and class of serotonin receptors present in the plasma membrane. The effects of chronic treatment of... -
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- The Role of Visceral Hypersensitivity in Irritable Bowel Syndrome: Pharmacological Targets and Novel Treatments
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Farzaei MH, Bahramsoltani R, Abdollahi , Rahimi R
- KMID: 2433449
- J Neurogastroenterol Motil.
- 2016 Oct;22(4):558-574.
- doi: 10.5056/jnm16001
Irritable bowel syndrome (IBS) is the most common disorder referred to gastroenterologists and is characterized by altered bowel habits, abdominal pain, and bloating. Visceral hypersensitivity (VH) is a multifactorial process... -
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- Clinical Practices and Outcomes on Chemotherapy-Induced Nausea and Vomiting Management in South Korea: Comparison with Asia-Pacific Data of the Pan Australasian Chemotherapy Induced Emesis Burden of Illness Study
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Lee MA, Cho EK, Oh SY, Ahn JB, Lee JY, Burke T, Jung H, Kim JG
- KMID: 2356244
- Cancer Res Treat.
- 2016 Oct;48(4):1420-1428.
- doi: 10.4143/crt.2015.309
PURPOSE: This study reported patient outcomes of chemotherapy-induced nausea and vomiting (CINV) prophylaxis for highly emetogenic chemotherapy (HEC) and moderately emetogenic chemotherapy (MEC) regimens and evaluated its adherence to acute-phase... -
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- Comparison of the efficacy of ramosetron and palonosetron for prevention of postoperative nausea and vomiting in patients undergoing gynecologic oncology surgery
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Yoon HJ, Jee YS, Kim YD
- KMID: 2344929
- Anesth Pain Med.
- 2016 Jul;11(3):264-268.
- doi: 10.17085/apm.2016.11.3.264
BACKGROUND: Postoperative nausea and vomiting (PONV) is a major concern during the post-surgical period. 5-hydroxy-tryptamine (5-HT3) receptor antagonists may be useful for the prevention of PONV. The recently developed 5-HT3... -
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- Mast Cells and Irritable Bowel Syndrome: From the Bench to the Bedside
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Zhang L, Song J, Hou X
- KMID: 2203567
- J Neurogastroenterol Motil.
- 2016 Apr;22(2):181-192.
- doi: 10.5056/jnm15137
Irritable bowel syndrome (IBS) is traditionally defined as a functional disorder since it lacks demonstrable pathological abnormalities. However, in recent years, low grade inflammatory infiltration, often rich in mast cells,... -
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- Serotonin as a New Therapeutic Target for Diabetes Mellitus and Obesity
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Oh CM, Park S, Kim H
- KMID: 2162080
- Diabetes Metab J.
- 2016 Apr;40(2):89-98.
- doi: 10.4093/dmj.2016.40.2.89
Serotonin (5-hydroxytryptamine [5-HT]) is a monoamine that has various functions in both neuronal and non-neuronal systems. In the central nervous system, 5-HT regulates mood and feeding behaviors as a neurotransmitter.... -
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- Pharmacologic Agents for Chronic Diarrhea
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Lee KJ
- KMID: 2070745
- Intest Res.
- 2015 Oct;13(4):306-312.
- doi: 10.5217/ir.2015.13.4.306
Chronic diarrhea is usually associated with a number of non-infectious causes. When definitive treatment is unavailable, symptomatic drug therapy is indicated. Pharmacologic agents for chronic diarrhea include loperamide, 5-hydroxytryptamine type... -
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- Association of 5-HT3B Receptor Gene Polymorphisms with the Efficacy of Ondansetron for Postoperative Nausea and Vomiting
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Kim MS, Lee JR, Choi EM, Kim EH, Choi SH
- KMID: 2163638
- Yonsei Med J.
- 2015 Sep;56(5):1415-1420.
- doi: 10.3349/ymj.2015.56.5.1415
PURPOSE: Postoperative nausea and vomiting (PONV) is a common problem after general anesthesia. Although 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists have significantly reduced PONV, over 35% of patients treated with... -
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- Distribution of 5-HT3, 5-HT4, and 5-HT7 Receptors Along the Human Colon
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Yaakob NS, Chinkwo KA, Chetty N, Coupar IM, Irving HR
- KMID: 2433475
- J Neurogastroenterol Motil.
- 2015 Jul;21(3):361-369.
- doi: 10.5056/jnm14157
BACKGROUND/AIMS: Several disorders of the gastrointestinal tract are associated with abnormal serotonin (5-HT) signaling or metabolism where the 5-HT3 and 5-HT4 receptors are clinically relevant. The aim was to examine... -
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- New Generation Laxatives
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Hong SN, Shin JE, Hong KS, Jung KW, Lee TH, Lee BE, Park SY, Kim SE, Park KS, Choi SC, Constipation Research group of the Korean Society of Neurogastroenterology and Motility
- KMID: 2269163
- Korean J Med.
- 2015 Jan;88(1):9-14.
- doi: 10.3904/kjm.2015.88.1.9
A significant proportion of chronic constipation patients are dissatisfied with their treatment. Recently, a number of new medications have been introduced for patients refractory to conventional laxatives, such as prucalopride,... -
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- The relationship between perioperative nausea and vomiting and serum serotonin concentrations in patients undergoing cesarean section under epidural anesthesia
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Lim BG, Choi SS, Jeong YJ, Lim YJ, Kim YC, Park KU, Lee DK, Lee MK
- KMID: 2425272
- Korean J Anesthesiol.
- 2014 Dec;67(6):384-390.
- doi: 10.4097/kjae.2014.67.6.384
BACKGROUND: Serotonin-also known as 5-hydroxytryptamine or 5-HT-can induce nausea and vomiting (NV) by peripheral mechanisms via the activation of 5-HT3 receptors. In this study, we observed perioperative NV, including intraoperative... -
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- Multicenter nonrandomized trial of ramosetron versus palonosetron in controlling chemotherapy-induced nausea and vomiting for colorectal cancer
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Kim JS, Kim JY, Lee SJ, Park DK, Namgung H, Kim CN, Choi WJ, Baek MJ
- KMID: 1804093
- Ann Surg Treat Res.
- 2014 Jul;87(1):9-13.
- doi: 10.4174/astr.2014.87.1.9
PURPOSE: Chemotherapy-induced nausea and vomiting (CINV) have a negative impact on patients' quality of life and frequently pointed to as a major factor for treatment abandonment. Serotonin (5-HT3) receptor antagonist... -
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- Strategy to Manage Irritable Bowel Syndrome in Korea
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Kim JH, Sung IK
- KMID: 2269332
- Korean J Med.
- 2014 Jun;86(6):695-697.
Irritable bowel syndrome (IBS) is one of the most prevalent functional gastrointestinal disorders. It is a multi-factorial disorder due to abnormal gastrointestinal motility, low-grade inflammation, visceral hypersensitivity, and communication between... -
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- Ginger and Its Pungent Constituents Non-Competitively Inhibit Serotonin Currents on Visceral Afferent Neurons
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Jin Z, Lee G, Kim S, Park CS, Park YS, Jin YH
- KMID: 2285504
- Korean J Physiol Pharmacol.
- 2014 Apr;18(2):149-153.
- doi: 10.4196/kjpp.2014.18.2.149
Nausea and emesis are a major side effect and obstacle for chemotherapy in cancer patients. Employ of antiemetic drugs help to suppress chemotherapy-induced emesis in some patients but not all... -
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