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The Role of Serotonin in Ventricular Repolarization in Pregnant Mice

Cui S, Park H, Park H, Mun D, Lee SH, Kim H, Yun N, Kim H, Kim M, Pak HN, Lee MH, Joung B

PURPOSE: The mechanisms underlying repolarization abnormalities during pregnancy are not fully understood. Although maternal serotonin (5-hydroxytryptamine, 5-HT) production is an important determinant for normal fetal development in mice, its role...
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Combination of nefopam and remifentanil is more effective to reduce rocuronium-induced withdrawal response compared with remifentanil alone: a prospective, double-blinded, randomized control study

Jung KT, Kim SH, So KY, Moon HM

BACKGROUND: We investigated the effect of combination of nefopam and remifentanil under the hypothesis that nefopam would effectively prevent rocuronium-induced withdrawal response by blocking serotonin receptors and providing a synergistic...
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Morphologic changes in the spinal cord following intrathecal palonosetron-HCl injection in rats

Yoo SH, Chung JH, Seo Y, Choi MK, Choi WK, Kim JB

BACKGROUND: Intravenous palonosetron-HCl, a second-generation antagonist of selective serotonin type 3 (5-HT3) receptors, can prevent chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV). 5-HT3 receptors are abundant...
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Serotonin reuptake inhibitors and bone health: A review of clinical studies and plausible mechanisms

Wadhwa R, Kumar M, Talegaonkar S, Vohora D

Selective serotonin reuptake inhibitors (SSRIs) are currently the treatment of choice in depression and constitute major portion of prescription in depressive patients. The role of serotonin receptors in bone is...
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Ketanserin and Naftopidil Enhance the Potentiating Effect of Alpha-Methyl-Serotonin on the Neurally-Induced Contraction of Human Isolated Urinary Bladder Muscle Strips

Hattori T, Lluel P, Rouget C, Rekik M, Yoshiyama

PURPOSE: The aim of this study was to assess the potential involvement of a specific subtype of 5-hydroxytryptamine (5-HT), 5HT(2) receptors in neurally-induced contractions of the human detrusor. METHODS: Contractile responses...
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Lamotrigine, an antiepileptic drug, inhibits 5-HT₃ receptor currents in NCB-20 neuroblastoma cells

Kim KJ, Jeun SH, Sung KW

Lamotrigine is an antiepileptic drug widely used to treat epileptic seizures. Using whole-cell voltage clamp recordings in combination with a fast drug application approach, we investigated the effects of lamotrigine...
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Hippocampal serotonin-2A receptor-immunoreactive neurons density increases after testosterone therapy in the gonadectomized male mice

Nikmahzar , Jahanshahi M, Ghaemi A, Naseri GR, Moharreri , Lotfinia A

The change of steroid levels may also exert different modulatory effects on the number and class of serotonin receptors present in the plasma membrane. The effects of chronic treatment of...
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The Role of Visceral Hypersensitivity in Irritable Bowel Syndrome: Pharmacological Targets and Novel Treatments

Farzaei MH, Bahramsoltani R, Abdollahi , Rahimi R

  • KMID: 2433449
  • J Neurogastroenterol Motil.
  • 2016 Oct;22(4):558-574.
  • doi: 10.5056/jnm16001
Irritable bowel syndrome (IBS) is the most common disorder referred to gastroenterologists and is characterized by altered bowel habits, abdominal pain, and bloating. Visceral hypersensitivity (VH) is a multifactorial process...
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Clinical Practices and Outcomes on Chemotherapy-Induced Nausea and Vomiting Management in South Korea: Comparison with Asia-Pacific Data of the Pan Australasian Chemotherapy Induced Emesis Burden of Illness Study

Lee MA, Cho EK, Oh SY, Ahn JB, Lee JY, Burke T, Jung H, Kim JG

PURPOSE: This study reported patient outcomes of chemotherapy-induced nausea and vomiting (CINV) prophylaxis for highly emetogenic chemotherapy (HEC) and moderately emetogenic chemotherapy (MEC) regimens and evaluated its adherence to acute-phase...
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Comparison of the efficacy of ramosetron and palonosetron for prevention of postoperative nausea and vomiting in patients undergoing gynecologic oncology surgery

Yoon HJ, Jee YS, Kim YD

BACKGROUND: Postoperative nausea and vomiting (PONV) is a major concern during the post-surgical period. 5-hydroxy-tryptamine (5-HT3) receptor antagonists may be useful for the prevention of PONV. The recently developed 5-HT3...
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Mast Cells and Irritable Bowel Syndrome: From the Bench to the Bedside

Zhang L, Song J, Hou X

  • KMID: 2203567
  • J Neurogastroenterol Motil.
  • 2016 Apr;22(2):181-192.
  • doi: 10.5056/jnm15137
Irritable bowel syndrome (IBS) is traditionally defined as a functional disorder since it lacks demonstrable pathological abnormalities. However, in recent years, low grade inflammatory infiltration, often rich in mast cells,...
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Serotonin as a New Therapeutic Target for Diabetes Mellitus and Obesity

Oh CM, Park S, Kim H

Serotonin (5-hydroxytryptamine [5-HT]) is a monoamine that has various functions in both neuronal and non-neuronal systems. In the central nervous system, 5-HT regulates mood and feeding behaviors as a neurotransmitter....
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Pharmacologic Agents for Chronic Diarrhea

Lee KJ

Chronic diarrhea is usually associated with a number of non-infectious causes. When definitive treatment is unavailable, symptomatic drug therapy is indicated. Pharmacologic agents for chronic diarrhea include loperamide, 5-hydroxytryptamine type...
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Association of 5-HT3B Receptor Gene Polymorphisms with the Efficacy of Ondansetron for Postoperative Nausea and Vomiting

Kim MS, Lee JR, Choi EM, Kim EH, Choi SH

PURPOSE: Postoperative nausea and vomiting (PONV) is a common problem after general anesthesia. Although 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists have significantly reduced PONV, over 35% of patients treated with...
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Distribution of 5-HT3, 5-HT4, and 5-HT7 Receptors Along the Human Colon

Yaakob NS, Chinkwo KA, Chetty N, Coupar IM, Irving HR

  • KMID: 2433475
  • J Neurogastroenterol Motil.
  • 2015 Jul;21(3):361-369.
  • doi: 10.5056/jnm14157
BACKGROUND/AIMS: Several disorders of the gastrointestinal tract are associated with abnormal serotonin (5-HT) signaling or metabolism where the 5-HT3 and 5-HT4 receptors are clinically relevant. The aim was to examine...
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New Generation Laxatives

Hong SN, Shin JE, Hong KS, Jung KW, Lee TH, Lee BE, Park SY, Kim SE, Park KS, Choi SC, Constipation Research group of the Korean Society of Neurogastroenterology and Motility

A significant proportion of chronic constipation patients are dissatisfied with their treatment. Recently, a number of new medications have been introduced for patients refractory to conventional laxatives, such as prucalopride,...
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The relationship between perioperative nausea and vomiting and serum serotonin concentrations in patients undergoing cesarean section under epidural anesthesia

Lim BG, Choi SS, Jeong YJ, Lim YJ, Kim YC, Park KU, Lee DK, Lee MK

BACKGROUND: Serotonin-also known as 5-hydroxytryptamine or 5-HT-can induce nausea and vomiting (NV) by peripheral mechanisms via the activation of 5-HT3 receptors. In this study, we observed perioperative NV, including intraoperative...
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Multicenter nonrandomized trial of ramosetron versus palonosetron in controlling chemotherapy-induced nausea and vomiting for colorectal cancer

Kim JS, Kim JY, Lee SJ, Park DK, Namgung H, Kim CN, Choi WJ, Baek MJ

PURPOSE: Chemotherapy-induced nausea and vomiting (CINV) have a negative impact on patients' quality of life and frequently pointed to as a major factor for treatment abandonment. Serotonin (5-HT3) receptor antagonist...
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Strategy to Manage Irritable Bowel Syndrome in Korea

Kim JH, Sung IK

  • KMID: 2269332
  • Korean J Med.
  • 2014 Jun;86(6):695-697.
Irritable bowel syndrome (IBS) is one of the most prevalent functional gastrointestinal disorders. It is a multi-factorial disorder due to abnormal gastrointestinal motility, low-grade inflammation, visceral hypersensitivity, and communication between...
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Ginger and Its Pungent Constituents Non-Competitively Inhibit Serotonin Currents on Visceral Afferent Neurons

Jin Z, Lee G, Kim S, Park CS, Park YS, Jin YH

Nausea and emesis are a major side effect and obstacle for chemotherapy in cancer patients. Employ of antiemetic drugs help to suppress chemotherapy-induced emesis in some patients but not all...
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