J Korean Neuropsychiatr Assoc.  1998 Mar;37(2):394-399.

Risperidone-Induced Mania in Psychoses

Affiliations
  • 1Department of Neuropsychiatry, College of Medicine, Soonchunhyang University, Seoul, Korea.

Abstract

Risperidone is one of a new class of atypical antipsychotic drug that combines potent dopamine(D2) and serotonin(5-HT2) receptor antagonist properties. In the last few years, there have been several report of risperidone-induced manic symptoms during treatment of schizoaffective disorder or schizophrenia. We report three cases of mania developed in two schizophrenia patients and one amphetamine-induced psychotic disorder which appear to have been precipitated by rispendone. This inducing effect might be attributed to its ability to block postsynaptic 5-HT2 receptors, a property that distinguishes it self from other antipsychotic agents. The blocking of serotonin receptors by risperidone may create a perceived depletion of serotonin similar to that seen in affective disorder and lead to mania. Therefore, we should be cautions in the treatment of psychotic disorder with risperidone.

Keyword

Risperidone; Mania; 5-HT2 receptor
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