- Riluzole Selective Antioxidant Effects in Cell Models Expressing Amyotrophic Lateral Sclerosis Endophenotypes
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Sala G, Arosio A, Conti E, Beretta S, Lunetta C, Riva N, Ferrarese , Tremolizzo L
- KMID: 2457408
- Clin Psychopharmacol Neurosci.
- 2019 Aug;17(3):438-442.
- doi: 10.9758/cpn.2019.17.3.438
OBJECTIVE: Until recently, riluzole was the only drug licensed for amyotrophic lateral sclerosis (ALS). In spite of its efficacy, the mechanism of action remains elusive, and both blocking of glutamate... -
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- Rhamnazin inhibits LPS-induced inflammation and ROS/RNS in raw macrophages
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Kim YJ
- KMID: 2357131
- J Nutr Health.
- 2016 Oct;49(5):288-294.
- doi: 10.4163/jnh.2016.49.5.288
PURPOSE: The aim of this work was to investigate the beneficial effects of rhamnazin against inflammation, reactive oxygen species (ROS)/reactive nitrogen species (RNS), and anti-oxidative activity in murine macrophage RAW264.7... -
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- Streptococcus mutans Strains Isolated in Korea Can Hardly Metabolize Exogenous Nitric Oxide
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Lee HJ, Bang IS
- KMID: 2133227
- Int J Oral Biol.
- 2015 Dec;40(4):217-221.
- doi: 10.11620/IJOB.2015.40.4.217
Cariogenic Streptococcus mutans encounters a variety of host defense factors produced in oral cavity. Nitric oxide (NO) and NO-mediated reactive nitrogen species are potential antimicrobials of innate immunity that can... -
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- Characterization of an Extracytoplasmic Chaperone Spy in Protecting Salmonella against Reactive Oxygen/Nitrogen Species
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Park YM, Lee HJ, Bang IS
- KMID: 2170789
- Int J Oral Biol.
- 2014 Dec;39(4):207-213.
- doi: 10.11620/IJOB.2014.39.4.207
Antimicrobial actions of reactive oxygen/nitrogen species (ROS/RNS) derived from products of NADPH oxidase and inducible nitric oxide (NO) synthase in host phagocytes inactivate various bacterial macromolecules. To cope with these... -
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- Diabetic Cardiomyopathy and Its Prevention by Nrf2: Current Status
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Chen J, Zhang Z, Cai L
- KMID: 2280677
- Diabetes Metab J.
- 2014 Oct;38(5):337-345.
- doi: 10.4093/dmj.2014.38.5.337
Diabetic cardiomyopathy (DCM), as one of the major cardiac complications in diabetic patients, is known to related with oxidative stress that is due to a severe imbalance between reactive oxygen... -
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- Clinical Applications of Antioxidants
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Park JH, Kweon GR
- KMID: 2168247
- Hanyang Med Rev.
- 2013 May;33(2):130-136.
- doi: 10.7599/hmr.2013.33.2.130
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are natural by-products of cellular physiological processes involving metabolism of compounds containing oxygen and nitrogen, respectively. Physiological defense mechanisms against ROS/RNS... -
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- A Systematic Review of Oxidative Stress and Safety of Antioxidants in Diabetes: Focus on Islets and Their Defense
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Karunakaran U, Park KG
- KMID: 2280711
- Diabetes Metab J.
- 2013 Apr;37(2):106-112.
- doi: 10.4093/dmj.2013.37.2.106
A growing body of evidence suggests that hyperglycemia-induced oxidative stress plays an important role in diabetic complications, especially beta-cell dysfunction and failure. Under physiological conditions, reactive oxygen species serve as... -
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- Reactive Oxygen and Nitrogen Species in Pathogenesis of Vascular Complications of Diabetes
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Son SM
- KMID: 2281399
- Diabetes Metab J.
- 2012 Jun;36(3):190-198.
- doi: 10.4093/dmj.2012.36.3.190
Macrovascular and microvascular diseases are currently the principal causes of morbidity and mortality in subjects with diabetes. Disorders of the physiological signaling functions of reactive oxygen species (superoxide and hydrogen... -
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- Direct Detection of Reactive Nitrogen Species in Experimental Autoimmune Uveitis
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Bae SR, Wu GS, Sevanian A, Schultz BE, Zamir E, Rao NA
- KMID: 1105026
- Korean J Ophthalmol.
- 2007 Mar;21(1):21-27.
- doi: 10.3341/kjo.2007.21.1.21
PURPOSE: Demonstrate unequivocally the generation of nitric oxide in experimental autoimmune uveoretinitis by electron spin resonance spectroscopy (ESR) using ferrous iron complex of N-methyl-D-glucamine dithiocarbamate, (MGD)2-Fe2+, as a spin... -
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- The Antioxidative and Antimicrobial Effects of Gloiopeltis Tenax
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Jung YH, Jung BM, Kang DY, Ku MJ, Shin MO, Bae SJ
- KMID: 2269984
- Korean J Nutr.
- 2006 Jun;39(4):366-371.
In this study, we investigated the antioxidative and antimicrobial activities of red algae Gloiopeltis tenax (GT). GT was extracted with methanol and then further fractionated it into four different types:... -
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- Influences of Particles on Pro-inflammatory Signalings in Pre-osteoclasts
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Choi YH, Yang HM, Lee JH, Choi JS, Kang YH, Shin SR, Park YW, Kim DY, Chang JD, Lee SS
- KMID: 1575165
- J Korean Orthop Res Soc.
- 2006 Apr;9(1):18-28.
PURPOSE: To evaluate the roles of macrophages and their influences on the signal transduction in the periprosthetic osteolysis, the pro-inflammatory signals were analyzed in particles-stimulated macrophages. MATERIALS AND METHODS: Raw 264.7... -
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- Comparison of the Protective Effect of Indole beta-carbolines and R-(-)-deprenyl Against Nitrogen Species-Induced Cell Death in Experimental Culture Model of Parkinson's Disease
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Han YS, Kim JM, Cho JS, Lee CS, Kim DE
- KMID: 2287717
- J Clin Neurol.
- 2005 Apr;1(1):81-91.
- doi: 10.3988/jcn.2005.1.1.81
BACKGROUND: The membrane permeability transition of mitochondria has been suggested to be involved in toxic and oxidative forms of cell injury. Mitochondrial dysfunction is considered to play a critical role... -
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- Acetoaminophen-induced accumulation of 8-oxodeoxyguanosine through reduction of Ogg1 DNA repair enzyme in C6 glioma cells
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Wan J, Bae MA, Song BJ
- KMID: 755668
- Exp Mol Med.
- 2004 Feb;36(1):71-77.
Large doses of acetaminophen (APAP) could cause oxidative stress and tissue damage through production of reactive oxygen/nitrogen (ROS/RNS) species and quinone metabolites of APAP. Although ROS/RNS are known to modify... -
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- Effect of NMDA Receptor Antagonist and NOS Inhibitor on Spinal Sensory Neurons of Neuropathic Pain Animal Model
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Lee KC, Choi YS, Lee HB, Park ST
- KMID: 1946651
- J Korean Pain Soc.
- 2002 Jun;15(1):13-18.
BACKGROUND: In order to evaluate the effect of N-methyl-D-aspartate (NMDA) receptor antagonist, D-2-amino-5-phosphonovaleric acid (APV), nitric oxide synthase (NOS) inhibitor, and aminoguanidine (AGH) on rat spinal sensory neurons from the... -
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- Effects of Particulate Matters on A549 and RAW 264.7 Cells
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Baak YM, Kim JH, Kim KA, Ro CU, Kim HJ, Lim Y
- KMID: 2140436
- Korean J Prev Med.
- 2001 Feb;34(1):41-46.
OBJECTIVES: To investigate the effects of particulate matter (PM), a marker of environmental pollution derived from combustion sources, on lung epithelial cells (A549) and macrophage (RAW 264.7). METHODS: The production of... -
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