- RNA polymerase II carboxy-terminal domain with multiple connections
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Cho EJ
- KMID: 1047075
- Exp Mol Med.
- 2007 Jun;39(3):247-254.
The largest subunit of eukaryotic RNA polymerase II contains a unique domain at its carboxy-terminus, which is referred to as the carboxy-terminal domain (CTD). The CTD is made up of... -
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- Expression and Localization of COMMD1 Proteins in Human Placentas from Women with Preeclampsia
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Kwon HS, Park SH, Hwang HS, Sohn IS, Kim SN
- KMID: 1503916
- Yonsei Med J.
- 2013 Mar;54(2):494-499.
- doi: 10.3349/ymj.2013.54.2.494
PURPOSE: Recently, COMMD1 has been identified as a novel interactor and regulator of hypoxia-inducible factor-1 and nuclear factor kappa B transcriptional activity. The goal of this study was to determine... -
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- Regulation of bcl-2 family in hydrogen peroxide-induced apoptosis in human leukemia HL-60 cells
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Lee JE, Sohn JW, Lee JH, Lee KC, Son CS, Tockgo YC
- KMID: 927133
- Exp Mol Med.
- 2000 Mar;32(1):42-46.
Numerous types of cells have been shown to undergo apoptosis when exposed to oxidant agent such as hydrogen peroxide. In order to understand the functional relationship between the anti- and... -
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- Tryptase and Protease-Activated Receptor 2 Expression Levels in Irritable Bowel Syndrome
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Liang WJ, Zhang G, Luo HS, Liang LX, Huang D, Zhang FC
- KMID: 2411965
- Gut Liver.
- 2016 May;10(3):382-390.
- doi: 10.5009/gnl14319
BACKGROUND/AIMS: Previous studies have revealed that mast cells (MCs) may activate the protease-activated receptors and release of neuropeptides involved in the pathogenesis of irritable bowel syndrome (IBS). The levels of... -
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- LRIG1 Enhances Chemosensitivity by Modulating BCL-2 Expression and Receptor Tyrosine Kinase Signaling in Glioma Cells
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Guo Z, Chen Q, Liu B, Tian D, Zhang S, Li M
- KMID: 1799481
- Yonsei Med J.
- 2014 Sep;55(5):1196-1205.
- doi: 10.3349/ymj.2014.55.5.1196
PURPOSE: Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) are an inhibitor of receptor tyrosine kinases (RTKs) that was discovered in recent years, and many studies showed that LRIG1 is a... -
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- Hypoxic Regulation of VEGF, HIF-1 (alpha) in Coronary Collaterals Development
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Sung KC, Kim KS, Lee S
- KMID: 1115253
- Korean J Intern Med.
- 2005 Dec;20(4):295-302.
- doi: 10.3904/kjim.2005.20.4.295
BACKGROUND: The interindividual variability for the development of collaterals in coronary artery disease is dependent on the hypoxic induction level of VEGF. To determine whether the hypoxic induction of VEGF... -
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- STAT3 and ERK Signaling Pathways Are Implicated in the Invasion Activity by Oncostatin M through Induction of Matrix Metalloproteinases 2 and 9
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Ko HS, Park BJ, Choi SK, Kang HK, Kim A, Kim HS, Park IY, Shin JC
- KMID: 2374099
- Yonsei Med J.
- 2016 May;57(3):761-768.
- doi: 10.3349/ymj.2016.57.3.761
PURPOSE: Our previous studies have shown that oncostatin M (OSM) promotes trophoblast invasion activity through increased enzyme activity of matrix metalloproteinase (MMP)-2 and -9. We further investigated OSM-induced intracellular signaling... -
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- Metformin Reduces Bleomycin-induced Pulmonary Fibrosis in Mice
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Choi SM, Jang AH, Kim H, Lee KH, Kim YW
- KMID: 2468274
- J Korean Med Sci.
- 2016 Sep;31(9):1419-1425.
- doi: 10.3346/jkms.2016.31.9.1419
Metformin has anti-inflammatory and anti-fibrotic effects. We investigated whether metformin has an inhibitory effect on bleomycin (BLM)-induced pulmonary fibrosis in a murine model. A total of 62 mice were divided... -
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- Knockdown of Bcl-xL Enhances Growth-Inhibiting and Apoptosis-Inducing Effects of Resveratrol and Clofarabine in Malignant Mesothelioma H-2452 Cells
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Lee YJ, Hwang IS, Lee YJ, Lee CH, Kim SH, Nam HS, Choi YJ, Lee SH
- KMID: 2069926
- J Korean Med Sci.
- 2014 Nov;29(11):1464-1472.
- doi: 10.3346/jkms.2014.29.11.1464
Mcl-1 and Bcl-xL, key anti-apoptotic proteins of the Bcl-2 family, have attracted attention as important molecules in the cell survival and drug resistance. In this study, we investigated whether inhibition... -
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- Pyrrolidine Dithiocarbamate Inhibits Nuclear Factor kappaB and Toll-Like Receptor 4 Expression in Rats with Acute Necrotizing Pancreatitis
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Xu M, Wang KN, Wu K, Wang XP
- KMID: 2155650
- Gut Liver.
- 2015 May;9(3):411-416.
- doi: 10.5009/gnl14050
BACKGROUND/AIMS: To investigate the expression of Toll-like receptor 4 (TLR4) in the pancreases of rats with acute necrotizing pancreatitis (ANP) and any changes upon treatment with pyrrolidine dithiocarbamate (PDTC), an... -
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- The Role of Focal Adhesion Kinase in the TGF-beta-Induced Myofibroblast Transdifferentiation of Human Tenon's Fibroblasts
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Hong S, Lee JB, Iizuka Y, Song YK, Seong GJ, Han SH
- KMID: 1120181
- Korean J Ophthalmol.
- 2012 Feb;26(1):45-48.
- doi: 10.3341/kjo.2012.26.1.45
PURPOSE: To investigate the role of focal adhesion kinase (FAK) in transforming growth factor (TGF)-beta-induced myofibroblast transdifferentiation of human Tenon's fibroblasts. METHODS: Primary cultured human Tenon's fibroblasts were exposed to TGF-beta1... -
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- Resveratrol Has Anabolic Effects on Disc Degeneration in a Rabbit Model
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Kwon YJ
- KMID: 2158045
- J Korean Med Sci.
- 2013 Jun;28(6):939-945.
- doi: 10.3346/jkms.2013.28.6.939
This study was done to evaluate whether injections of resveratrol, a natural compound found in the skin of grapes, had anabolic effects on degenerated intervertebral discs in a rabbit model.... -
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- Effects of interleukin-10 on chemokine KC gene expression by mouse peritoneal macrophages in response to Candida albicans
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Kim HS, Shin DH, Kim SK
- KMID: 646014
- J Korean Med Sci.
- 1999 Oct;14(5):480-486.
- doi: 10.3346/jkms.1999.14.5.480
Chemokine KC has been considered to be a murine homologue of human GRO/MGSA and was identified as chemoattractant for monocytes and neutrophils. This study examined the expression of KC mRNA... -
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- The Glucotoxicity Protecting Effect of Ezetimibe in Pancreatic Beta Cells via Inhibition of CD36
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Yoon JS, Moon JS, Kim YW, Won KC, Lee HW
- KMID: 2363693
- J Korean Med Sci.
- 2016 Apr;31(4):547-552.
- doi: 10.3346/jkms.2016.31.4.547
Inhibition of CD36, a fatty acid transporter, has been reported to prevent glucotoxicity and ameliorate high glucose induced beta cell dysfunction. Ezetimibe is a selective cholesterol absorption inhibitor that blocks... -
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- Jak1/Stat3 Is an Upstream Signaling of NF-kappaB Activation in Helicobacter pylori-Induced IL-8 Production in Gastric Epithelial AGS Cells
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Cha B, Lim JW, Kim H
- KMID: 2450365
- Yonsei Med J.
- 2015 May;56(3):862-866.
- doi: 10.3349/ymj.2015.56.3.862
Helicobacter pylori (H. pylori) induces the activation of nuclear factor-kB (NF-kappaB) and cytokine expression in gastric epithelial cells. The Janus kinase/signal transducers and activators of transcription (Jak/Stat) cascade is the... -
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- Cholera toxin mediated regulation of the expression of Gq alpha and G11 alpha GTP binding proteins
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Shah BH
- KMID: 1029937
- Exp Mol Med.
- 1999 Jun;31(2):89-94.
Previously it has been shown that persistent activation of the stimulatory adenylyl cyclase pathway with cholera toxin (CT) downregulates the Gs alpha polypeptide (80%) in a cAMP-independent manner in C6 glioma cells... -
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- Toll-Like Receptor 4 Signaling is Involved in IgA-Stimulated Mesangial Cell Activation
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Lim BJ, Lee D, Hong SW, Jeong HJ
- KMID: 1727993
- Yonsei Med J.
- 2011 Jul;52(4):610-615.
- doi: 10.3349/ymj.2011.52.4.610
PURPOSE: Deposition of polymeric IgA1 in the kidney mesangium is the hallmark of IgA nephropathy, but the molecular mechanisms of IgA-mediated mesangial responses and inflammatory injuries remain poorly understood. We... -
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- Acute Modulations in Stratum Corneum Permeability Barrier Function Affect Claudin Expression and Epidermal Tight Junction Function via Changes of Epidermal Calcium Gradient
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Baek JH, Lee SE, Choi KJ, Choi EH, Lee SH
- KMID: 1503920
- Yonsei Med J.
- 2013 Mar;54(2):523-528.
- doi: 10.3349/ymj.2013.54.2.523
Tight junction (TJ) is recognized as a second barrier of the skin. Altered expression of TJ proteins in various skin diseases characterized by the abnormal permeability barrier such as psoriasis... -
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- DNA Hypomethylation-Mediated Overexpression of Carbonic Anhydrase 9 Induces an Aggressive Phenotype in Ovarian Cancer Cells
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Sung HY, Ju W, Ahn JH
- KMID: 2070216
- Yonsei Med J.
- 2014 Nov;55(6):1656-1663.
- doi: 10.3349/ymj.2014.55.6.1656
PURPOSE: Both genetic and epigenetic alterations can lead to abnormal expression of metastasis-regulating genes in tumor cells. Recent studies suggest that aberrant epigenetic alterations, followed by differential gene expression, leads... -
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- Clinical Usefulness of Glucocorticoid Receptor beta Expression and NF-kappa B Activity in Patients with Ulcerative Colitis
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Kim KJ, Myung SJ, Hong SS, Lee YJ, Lee SM, Byeon JS, Yang SK, Hong WS, Kim JH, Min YI
- KMID: 2439744
- Korean J Gastroenterol.
- 2005 Feb;45(2):103-110.
BACKGROUND/AIMS: Glucocorticoid resistance poses a challenging clinical problem in inflammatory bowel disease because more than one fourth of patients with severe ulcerative colitis do not respond to anti-inflammatory steroids.... -
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