- The Role of Oxidative Stress in the Pathogenesis of Asthma
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Cho YS, Moon HB
- KMID: 2133806
- Allergy Asthma Immunol Res.
- 2010 Jul;2(3):183-187.
- doi: 10.4168/aair.2010.2.3.183
Oxidative stress plays a critical role in the pathogenesis of asthma. To effectively control oxidative stress in asthmatics, it is important to investigate the precise intracellular mechanism by which the... -
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- Reactive Oxygen Species and Cellular Function Switch
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Ryu SE
- KMID: 2168240
- Hanyang Med Rev.
- 2013 May;33(2):104-109.
- doi: 10.7599/hmr.2013.33.2.104
Reactive oxygen species (ROS) are harmful to cellular components such as proteins, DNA and lipids. The continuous production of ROS during the respiratory electron transfer process has been regarded as... -
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- Comparative Analysis of Protein Tyrosine Phosphatases Regulating Microglial Activation
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Song GJ, Kim J, Kim JH, Song S, Park H, Zhang ZY, Suk K
- KMID: 2354878
- Exp Neurobiol.
- 2016 Oct;25(5):252-261.
- doi: 10.5607/en.2016.25.5.252
Protein tyrosine phosphatases (PTPs) are key regulatory factors in inflammatory signaling pathways. Although PTPs have been extensively studied, little is known about their role in neuroinflammation. In the present study,... -
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- Phosphorylation of chicken protein tyrosine phosphatase 1 by casein kinase II in vitro
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Jung EJ, Kang KR, Kang YS
- KMID: 1532667
- Exp Mol Med.
- 1997 Dec;29(4):229-233.
The phosphorylation and dephosphorylation of proteins on tyrosyl residues are key regulatory mechanisms of cell growth and signal transduction and are controlled by opposing activities of protein tyrosine kinases and... -
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- Modulation of L-type Ca2+ channel currents by various protein kinase activators and inhibitors in rat clonal pituitary GH3 cell line
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Bae YM, Baek HJ, Cho HN, Earm YE, Ho WK
- KMID: 2285234
- Korean J Physiol Pharmacol.
- 2001 Apr;5(2):139-146.
L-type Ca2+ channels play an important role in regulating cytosolic Ca2+ and thereby regulating hormone secretions in neuroendocrine cells. Since hormone secretions are also regulated by various kinds of protein kinases, we investigated... -
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- Protein tyrosine phosphatase 1B is a mediator of cyclic ADP ribose-induced Ca²⺠signaling in ventricular myocytes
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Park SA, Hong BZ, Ha KC, Kim UH, Han MK, Kwak YG
- KMID: 2386961
- Exp Mol Med.
- 2017 Jun;49(6):e341.
- doi: 10.1038/emm.2017.68
Cyclic ADP-ribose (cADPR) releases Ca²⺠from ryanodine receptor (RyR)-sensitive calcium pools in various cell types. In cardiac myocytes, the physiological levels of cADPR transiently increase the amplitude and frequency of... -
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- Role of Tyrosine Kinases in Norepinephrine-Induced Vascular Contraction in Renal Hypertensive Rats
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Yeum CH, Jun JY, Yoon PJ, Shin MK, Cho HH, Jang JS, Hong SP, Yeum CH
- KMID: 1938830
- Korean Circ J.
- 2002 Oct;32(10):894-901.
- doi: 10.4070/kcj.2002.32.10.894
BACKGROUND AND OBJECTIVES: Protein tyrosine kinases appear to be involved in the signal transduction mechanisms, which result in vascular smooth muscle contraction, as well those required in cell growth. The... -
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- Association of Killer Cell Ig-like Receptor (KIR) with an Adaptor Protein Shc
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Cho HI, Chwae YJ, Park SM, Kim J
- KMID: 2150616
- Immune Netw.
- 2006 Jun;6(2):67-75.
- doi: 10.4110/in.2006.6.2.67
BACKGROUND: Cytotoxic function of killer cells is inhibited by specific recognition of class I MHC molecules on target cells by inhibitory killer Ig-like receptors (KIR) expressed on NK cells and... -
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- The long-term effect of ramipril on Gialpha2-protein and Protein Tyrosine Phosphatase 1B in an animal model of type 2 diabetes(OLETF rat)
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Lee JM, Hong OK, Kwon HS, Moon SD, Chang SA, Son HS, Yoon KH, Cha BY, Kang SK
- KMID: 2331782
- J Korean Diabetes Assoc.
- 2006 Jan;30(1):25-38.
BACKGROUND: The regulation of tyrosine phosphorylation/dephosphorylation is an important mechanism in various intracellular metabolism. Also impaired insulin signal transduction is important in pathogenesis of type 2 diabetes. It has been... -
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- Identification of the Marker-Genes for Dioxin(2,3,7,8-tetradibenzo-p-dioxin)-Induced Immune Dysfunction by Using the High-Density Oligonucleotide Microarray
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Kim JA, Lee EJ, Kim HL
- KMID: 2166168
- Genomics Inform.
- 2004 Jun;2(2):75-80.
In a variety of animal species, the perinatal exposure of experimental animals to the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) leads to the immune dysfunction, which is more severe and persistent than that caused... -
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- The Effect of Disodium Etidronate on Phosphatase Activity in Experimental bone Formation of Rats
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Roh KJ, Ahn YS, Choi JY
- KMID: 2443199
- J Korean Orthop Assoc.
- 1990 Dec;25(6):1761-1776.
- doi: 10.4055/jkoa.1990.25.6.1761
The bone formation of periarticular connective tissue after head injury and total hip arthroplasty is included in the category of heterotopic ossification. Induction of a new bone formation in the... -
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- A single fraction from Uncaria sinensis exerts neuroprotective effects against glutamate-induced neurotoxicity in primary cultured cortical neurons
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Kim HN, Jang JY, Choi BT
- KMID: 1845277
- Anat Cell Biol.
- 2015 Jun;48(2):95-103.
- doi: 10.5115/acb.2015.48.2.95
We identified a neuroprotective single fraction among 62 ones of hexane extract from Uncaria sinensis (JGH43IA) and investigated its effects and mechanisms in primary cortical neurons. Pretreatment with JGH43IA showed... -
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- Effect of Orthovanadate on Collagen and Fibronectin Synthesis, and Alkaline Phosphatase Activity in MC3E3-E1 Osteoblast cells
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Kim SY, Ihn JC, Choi JY, Ahn JC
- KMID: 2105968
- J Korean Orthop Assoc.
- 2003 Apr;38(2):133-141.
PURPOSE: The purpose: of this study was to know the effect of inhibition of protein dephosphorylation on the synthesis of collagen and fibronectin (FN), alkaline phosphatase (ALP) activity, and the... -
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- Propofol Inhibits Platelet-derived Growth Factor-stimulated Migration in Rat Aortic Smooth Muscle Cells
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Lee K, Lee K, Kim B, Lim J, Koo J, Lee M, Lee HM, Lee CK, Won KJ
- KMID: 2239834
- Korean J Anesthesiol.
- 2008 Mar;54(3):S22-S28.
- doi: 10.4097/kjae.2008.54.3.S22
BACKGROUND: Propofol is the extensively used general anesthetic-sedative agent.Although propofol is known to be involved in migration of various cells, migration response to it in vascular smooth muscle cells is... -
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- Two Cases of X-Linked Myotubular Myopathy with Novel MTM1 Mutations
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Lee EH, Yum MS, Park SJ, Lee BH, Kim GH, Yoo HW, Ko TS
- KMID: 2287572
- J Clin Neurol.
- 2013 Jan;9(1):57-60.
- doi: 10.3988/jcn.2013.9.1.57
BACKGROUND: Myotubular myopathy (MTM) is a congenital myopathy characterized by centrally placed nuclei in muscle fibers. Mutations in the myotubularin 1 gene (MTM1) have been identified in the most of... -
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- Protein Tyrosine Phosphatase N1 Gene Variants Associated with Type 2 Diabetes Mellitus and Its Related Phenotypes in the Korean Population
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Hong KW, Jin HS, Lim JE, Ryu HJ, Ahn Y, Lee JY, Han BG, Shin HD, Cho NH, Shin C, Woo JT, Park HK, Oh B
- KMID: 2166401
- Genomics Inform.
- 2008 Sep;6(3):99-109.
Protein phosphorylation at tyrosine residues is a key regulatory event that modulates insulin signal transduction. We studied the PTPN1 gene with regard to susceptibility to Korean type 2 diabetes mellitus (T2DM)... -
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- Characterization of Monoclonal Antibodies against Human Leukocyte Common Antigen (CD45)
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Shin HM, Cho WD, Lee GK, Lee SH, Lee KM, Ji GY, Yoon SS, Koo JH, Lee HC, Lee KH, Song HG
- KMID: 2150699
- Immune Netw.
- 2011 Apr;11(2):114-122.
- doi: 10.4110/in.2011.11.2.114
BACKGROUND: The leukocyte common antigen (CD45) is a transmembrane-type protein tyrosine phosphatase that has five isoforms. METHODS: We generated seven murine mAbs against human CD45 by injecting cells from different origins,... -
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- PRL-3 Expression in Primary Colorectal Cancer
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Lee HJ, Chu CW, Baek MJ, Shin EJ, Kim HC, Cho GS, Song OP, Kim HK, Park HJ
- KMID: 2199205
- J Korean Soc Coloproctol.
- 2007 Dec;23(6):497-502.
- doi: 10.3393/jksc.2007.23.6.497
PURPOSE: Overexpression of the protein tyrosine phosphatase (PRL-3) is elevated in liver metastases derived from colorectal cancer. We examined PRL-3 expression in the primary lesion of colorectal cancer patients and... -
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- Combined Measurements of Anti-ICA512 and Anti-GAD Antibodies in Insulin-dependent Diabetes Mellitus and Slowly Progressive Insulin-dependent Diabetes Mellitus in Korea
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Kim KA, Ahn KJ, Chung JH, Min YK, Lee MK, Oh PS, Jin DK, Kim BT, Park HJ, Kim KW, Lee MS
- KMID: 2331692
- J Korean Diabetes Assoc.
- 1998 Dec;22(4):482-490.
BACKGROUND: Type 1 diabetes mellitus is a chronic autoimmune disease in which circulating antibodies to various islet-specific antigens including autoantibodies to glutamic acid decarboxylase (GADAb), antibodies reacting with an islet... -
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- Correlation between Liver Metastases and the Level of PRL-3 mRNA Expression in Patients with Primary Colorectal Cancer
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Kim NW, Chu CW, Ahn TS, Kim CJ, Jung DJ, Son MW, Bae SH, Lee MS, Kim CH, Baek MJ
- KMID: 2198734
- J Korean Soc Coloproctol.
- 2011 Oct;27(5):231-236.
- doi: 10.3393/jksc.2011.27.5.231
PURPOSE: Phosphatase of regenerating liver-3 (PRL-3) has been associated with metastasis promotion. However, clinical applications of this association have not yet been clearly demonstrated. In this study, we evaluated the... -
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