- Opening of ATP-sensitive K+ channel by pinacidil requires serine/threonine phosphorylation in rat ventricular myocytes
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Kwak YG, Chae SW
- KMID: 2285223
- Korean J Physiol Pharmacol.
- 1999 Jun;3(3):293-303.
The influences of specific protein phosphatase and protein kinase inhibitors on the ATP-sensitive K+ (KATP) channel-opening effect of pinacidil were investigated in single rat ventricular myocytes using patch clamp technique. In cell-attached patches,... -
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- Regulatory B Subunits of Protein Phosphatase 2A Are Involved in Site-specific Regulation of Tau Protein Phosphorylation
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Yu UY, Yoo BC, Ahn JH
- KMID: 2285505
- Korean J Physiol Pharmacol.
- 2014 Apr;18(2):155-161.
- doi: 10.4196/kjpp.2014.18.2.155
Overexpression of amyloid precursor protein with the Swedish mutation causes abnormal hyperphosphorylation of the microtubule-associated protein tau. Hyperphosphorylated isoforms of tau are major components of neurofibrillary tangles, which are histopathological... -
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- Focal Cerebral Ischemia Reduces Protein Phosphatase 2A Subunit B Expression in Brain Tissue and HT22 Cells
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Koh PO
- KMID: 2391863
- Lab Anim Res.
- 2011 Mar;27(1):73-76.
Protein phosphatase 2A (PP2A) is a serine and threonine protein phosphatase that regulates cell cycle progression and apoptosis. PP2A is composed of various subunits. Among these subunits, subunit B plays... -
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- Curcumin treatment recovery the decrease of protein phosphatase 2A subunit B induced by focal cerebral ischemia in Sprague-Dawley rats
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Shah FA, Park DJ, Gim SA, Koh PO
- KMID: 2312130
- Lab Anim Res.
- 2015 Sep;31(3):134-138.
- doi: 10.5625/lar.2015.31.3.134
Curcumin provides various biological effects through its anti-inflammatory and antioxidant properties. Moreover, curcumin exerts a neuroprotective effect against ischemic condition-induced brain damage. Protein phosphatase 2A (PP2A) is a ubiquitous serine... -
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- Cardamonin Suppresses TGF-beta1-Induced Epithelial Mesenchymal Transition via Restoring Protein Phosphatase 2A Expression
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Kim EJ, Kim HJ, Park MK, Kang GJ, Byun HJ, Lee H, Lee CH
- KMID: 2380347
- Biomol Ther.
- 2015 Mar;23(2):141-148.
- doi: 10.4062/biomolther.2014.117
Epithelial mesenchymal transition (EMT) is the first step in metastasis and implicated in the phenotype of cancer stem cells. Therefore, understanding and controlling EMT, are essential to the prevention and... -
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- Propofol Inhibits Platelet-derived Growth Factor-stimulated Migration in Rat Aortic Smooth Muscle Cells
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Lee K, Lee K, Kim B, Lim J, Koo J, Lee M, Lee HM, Lee CK, Won KJ
- KMID: 2239834
- Korean J Anesthesiol.
- 2008 Mar;54(3):S22-S28.
- doi: 10.4097/kjae.2008.54.3.S22
BACKGROUND: Propofol is the extensively used general anesthetic-sedative agent.Although propofol is known to be involved in migration of various cells, migration response to it in vascular smooth muscle cells is... -
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- Telmisartan Inhibits Nitric Oxide Production and Vessel Relaxation via Protein Phosphatase 2A-mediated Endothelial NO Synthase-Ser¹¹â·â¹ Dephosphorylation
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Cho DH
- KMID: 2461172
- J Korean Med Sci.
- 2019 Nov;34(42):e266.
- doi: 10.3346/jkms.2019.34.e266
BACKGROUND: Apart from its blood pressure-lowering effect by blocking the renin-angiotensin-aldosterone system, telmisartan, an angiotensin II type 1 receptor blocker (ARB), exhibits various ancillary effects including cardiovascular protective effects in... -
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- Modulation of Ca2+ activated potassium channels by cGMP-dependent signal transduction mechanism in cerebral arterial smooth muscle cells of the rabbit
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Han J, Kim N, Lee K, Kim E
- KMID: 1581022
- Korean J Physiol Pharmacol.
- 2000 Dec;4(6):445-453.
The present investigation tested the hypothesis that the activation of protein kinase G (PKG) leads to a phosphorylation of Ca2+-activated potassium channel (KCa channel) and is involved in the activation of KCa channel... -
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