- Role of Mitogen Activated Protein Kinase and PI 3-kinase on Cell Proliferation in Pancreatic Cancer Cell Lines with K-ras Mutation
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Ryu JK, Kim J, Chang YH, Lee WJ, Kim YT, Yoon YB, Kim CY
- KMID: 2240269
- Korean J Gastroenterol.
- 2000 Sep;36(3):372-382.
No Abstract Available. -
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- Current update in diverse diseases
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Koh SH
- KMID: 2384000
- Hanyang Med Rev.
- 2017 May;37(1):1-1.
- doi: 10.7599/hmr.2017.37.1.1
No abstract available. -
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- Phosphatidylinositol-3-kinase Inhibitor Enhances Nitric Oxide Synthesis and Apoptosis in LPS-Stimulated Macrophages
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Park YC
- KMID: 1610767
- Korean J Anat.
- 2003 Aug;36(4):323-329.
Phosphatidylinositol-3-kinase (PI3-kinase) is critical player in cell proliferation and death. The mechanism by which bacterial lipopolysaccharide (LPS) induces synthesis of nitric oxide (NO) in murine macrophages is incompletely understood. In... -
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- Molecules and their functions in autophagy
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Pyo JO, Nah J, Jung YK
- KMID: 1120125
- Exp Mol Med.
- 2012 Feb;44(2):73-80.
- doi: 10.3858/emm.2012.44.2.029
Autophagy is a self-degradation system of cellular components through an autophagosomal-lysosomal pathway. Over the last 15 yr, yeast genetic screens led to the identification of a number of genes involved... -
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- Effect of Inositol-phosphatase on Fc Receptor-mediated Phagocytosis of Macrophages
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Kim JH
- KMID: 2150609
- Immune Netw.
- 2005 Sep;5(3):144-149.
- doi: 10.4110/in.2005.5.3.144
BACKGROUND: Fc receptor-mediated phagocytosis is a complex process involving the activation of kinases and phosphatases. FcgammaRIIB has been known to transduces inhibitory signals through an immunoreceptor tyrosine-based inhibitory motif (ITIM)... -
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- Phosphatidylinositol 4-phosphate 5-kinase alpha negatively regulates nerve growth factor-induced neurite outgrowth in PC12 cells
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Liu T, Lee SY
- KMID: 2154235
- Exp Mol Med.
- 2013 Mar;45(3):e16.
Neurite outgrowth, a cell differentiation process involving membrane morphological changes, is critical for neuronal network and development. The membrane lipid, phosphatidylinositol (PI) 4,5-bisphosphate (PIP2), is a key regulator of many... -
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- Apoptotic Cell Death Induced by Disruption of Epithelial Cell and Extracellular Matrix Interactions in Mouse Inner Medullary Collection Duct Cells
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Cheon JS, Park MY, Kim YK, Lee SH, Jung JS
- KMID: 1968463
- Korean J Nephrol.
- 1999 Jan;18(1):37-45.
Cell-matrix interactions have major effects upon phenotypic features such as gene regulation, cytoskeletal structure, differentiation, and aspects of cell growth control. Upon detachment from the matrix epithelial cells enter into... -
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- Role of Shc and phosphoinositide 3-kinase in heregulin-induced mitogenic signaling via ErbB3
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Kim MS, Koland JG
- KMID: 1581029
- Korean J Physiol Pharmacol.
- 2000 Dec;4(6):507-513.
ErbB3/HER3 is a cell surface receptor which belongs to the ErbB/HER subfamily of receptor protein tyrosine kinases. When expressed in NIH/3T3 cells, ErbB3 can form heterodimeric coreceptor with endogenous ErbB2. Among known intracellular... -
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- Amphetamine-induced ERM Proteins Phosphorylation Is through PKCbeta Activation in PC12 Cells
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Jeong HJ, Kim JH, Jeon S
- KMID: 1448929
- Korean J Physiol Pharmacol.
- 2011 Aug;15(4):245-249.
- doi: 10.4196/kjpp.2011.15.4.245
Amphetamine, a synthetic psychostimulant, is transported by the dopamine transporter (DAT) to the cytosol and increases the exchange of extracellular amphetamine by intracellular dopamine. Recently, we reported that the phosphorylation... -
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- Kappa-opioid receptor activation during reperfusion limits myocardial infarction via ERK1/2 activation in isolated rat hearts
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Kim JH, Jang YH, Chun KJ, Kim J, Park YH, Kim JS, Kim JM, Lee MY
- KMID: 1780180
- Korean J Anesthesiol.
- 2011 May;60(5):351-356.
- doi: 10.4097/kjae.2011.60.5.351
BACKGROUND: We investigated whether p42/p44 extracellular signal-regulated kinases (ERK1/2) and/or phosphatidylinositol-3-OH kinase (PI3K)-Akt play a crucial role in cardioprotection by kappa-opioid receptor (KOP) activation. METHODS: Langendorff perfused rat hearts were subjected... -
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- Up-regulation of P13K/Akt Signaling by 17 beta-estradiol through Activation of Estrogen Receptor-alpha in Breast Cancer Cells
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So MC, Hwang HP, Lee CH, Youn HJ, Jung SH, Kim JC
- KMID: 2286625
- J Breast Cancer.
- 2006 Jun;9(2):91-97.
- doi: 10.4048/jbc.2006.9.2.91
PURPOSE: Estrogen stimulates cell proliferation in breast cancer, the biological effects of which are mediated through two intracellular receptors: estrogen receptor-alpha (ERalpha) and estrogen receptor-beta (ERbeta). However, the actual role... -
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- Dual Inhibition of PI3K/Akt/mTOR Pathway and Role of Autophagy in Non-Small Cell Lung Cancer Cells
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Jeong EH, Choi HS, Lee TG, Kim HR, Kim CH
- KMID: 2319806
- Tuberc Respir Dis.
- 2012 Apr;72(4):343-351.
BACKGROUND: The phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling axis has emerged as a novel target for cancer therapy. Agents that inhibit this pathway are currently under development for... -
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- Hexane Extract of Orthosiphon stamineus Induces Insulin Expression and Prevents Glucotoxicity in INS-1 Cells
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Lee HJ, Choi YJ, Park SY, Kim JY, Won KC, Son JK, Kim YW
- KMID: 2280657
- Diabetes Metab J.
- 2015 Feb;39(1):51-58.
- doi: 10.4093/dmj.2015.39.1.51
BACKGROUND: Hyperglycemia, a characteristic feature of diabetes, induces glucotoxicity in pancreatic beta-cells, resulting in further impairment of insulin secretion and worsening glycemic control. Thus, preservation of insulin secretory capacity is... -
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- Comparative effects of PKB- alpha and PKC- zeta on the phosphorylation of GLUT4-containing vesicles in rat adipocytes
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Hah JS
- KMID: 1581027
- Korean J Physiol Pharmacol.
- 2000 Dec;4(6):487-496.
Insulin stimulates glucose transport in muscle and fat cells by promoting the translocation of glucose transporter (GLUT4) to the cell surface. Phosphatidylinositide 3-kinase (PI3-kinase) has been implicated in this process. However, the involvement... -
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- GLUT phosphorylation may be required to GLUT translocation mechanism
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Hah JS
- KMID: 1581028
- Korean J Physiol Pharmacol.
- 2000 Dec;4(6):497-506.
In this work, GLUTs phosphorylations by a downstream effector of PI3-kinase, PKC- zeta, were studied, and GLUT4 phosphorylation was compared with GLUT2 phosphorylation in relation to the translocation mechanism. Prior to phosphorylation experiment,... -
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- 7,8,4′-Trihydroxyisoflavone, a Metabolized Product of Daidzein, Attenuates 6-Hydroxydopamine-Induced Neurotoxicity in SH-SY5Y Cells
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Ko YH, Kim SK, Kwon SH, Seo JY, Lee BR, Kim YJ, Hur KH, Kim SY, Lee SY, Jang CG
- KMID: 2455091
- Biomol Ther.
- 2019 Jul;27(4):363-372.
- doi: 10.4062/biomolther.2018.211
Daidzein isolated from soybean (Glycine max) has been widely studied for its antioxidant and anti-inflammatory activities. However, the protective effects of 7,8,4′-trihydroxyisoflavone (THIF), a major metabolite of daidzein, on 6-hydroxydopamine... -
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- The Tumor Suppressor Function of PTEN/MMAC1 through the Regulation of IGFs and IGFBPs
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Yi HK, Hwang DJ, Kim SY, Lee DY, Hwang PH
- KMID: 1875814
- Korean J Pediatr.
- 2004 Aug;47(8):884-891.
PURPOSE: PTEN/MMAC1, a novel tumor suppressor gene, is mutated in a variety of advanced and metastatic cancers. It acts as a phosphatase, and thereby, regulates the PI-3 kinase/Akt pathway. In... -
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- The Role of Akt-1/PKBalpha on Insulin Action in 3T3-L1 Adipocyte
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Lee JM, Son HS, Kwon HS, Kwack SK, Ko SH, Chang SA, Yoon KH, Cha BY, Lee KW, Son HY, Kang SK, Sharma P
- KMID: 2177818
- J Korean Diabetes Assoc.
- 2002 Aug;26(4):274-285.
BACKGROUNDS: Akt/PKB as a serine/threonine kinase is stimulated by insulin and other growth factors. And insulin stimulates glucose uptake by promoting the translocation of glucose transporter 4 (GLUT4) to the... -
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- IL-15 Induced an Increased SDF-1 Expression in the Synovial Fibroblasts of Patients with Rheumatoid Arthritis
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Park YE, Kim SI, Park SH, Baek SH, Oh HJ, Heo YM, Cho ML
- KMID: 2334911
- J Korean Rheum Assoc.
- 2010 Sep;17(3):238-245.
OBJECTIVE: Interleukin-15 (IL-15) recruits and activates synovial T cells, and IL-15 plays an important role in amplifying and perpetuating inflammation in the pathogenesis of rheumatoid arthritis (RA). Stromal cell-derived factor-1... -
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- Synergistic induction of cancer cell migration regulated by Gbetagamma and phosphatidylinositol 3-kinase
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Kim EK, Yun SJ, Ha JM, Kim YW, Jin IH, Woo DH, Lee HS, Ha HK, Bae SS
- KMID: 1387359
- Exp Mol Med.
- 2012 Aug;44(8):483-491.
Phosphatidylinositol 3-kinase (PI3K) is essential for both G protein-coupled receptor (GPCR)- and receptor tyrosine kinase (RTK)-mediated cancer cell migration. Here, we have shown that maximum migration is achieved by full... -
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