- Comparison of In Vivo Pharmacokinetics and Pharmacodynamics of Vancomycin Products Available in Korea
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Kim HK, Choi SM, Kang G, Park KH, Lee DG, Park WB, Rhee SJ, Lee S, Jung SI, Jang HC
- KMID: 2471915
- Yonsei Med J.
- 2020 Apr;61(4):301-309.
- doi: 10.3349/ymj.2020.61.4.301
PURPOSE: Few studies have been investigated the in vivo efficacy of generic vancomycin products available outside of the United States. In this study, we aimed to compare the in vivo... -
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- Elucidation of the pathophysiology of intradialytic muscle cramps: pharmacokinetics applied to translational research
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Atkinson A
- KMID: 2467964
- Transl Clin Pharmacol.
- 2019 Dec;27(4):119-122.
- doi: 10.12793/tcp.2019.27.4.119
In the conventional concept of translational research, investigations flow from the laboratory bench to the bedside. However, clinical research can also serve as the starting point for subsequent laboratory investigations... -
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- Comments on: Pharmacokinetics of cisplatin during open and minimally-invasive secondary cytoreductive surgery plus HIPEC in women with platinum-sensitive recurrent ovarian cancer: a prospective study
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Batista TP, Kusamura S
- KMID: 2458907
- J Gynecol Oncol.
- 2019 Nov;30(6):e111.
- doi: 10.3802/jgo.2019.30.e111
No abstract available. -
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- Simultaneous quantification of ticagrelor and its active metabolite, AR-C124910XX, in human plasma by liquid chromatography-tandem mass spectrometry: Applications in steady-state pharmacokinetics in patients
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Chae SU, Min KL, Lee CB, Huang Z, Chang MJ, Bae SK
- KMID: 2458949
- Transl Clin Pharmacol.
- 2019 Sep;27(3):98-106.
- doi: 10.12793/tcp.2019.27.3.98
A sensitive and simple liquid chromatography-tandem mass spectrometry method was developed and validated for the simultaneous quantification of ticagrelor and its active metabolite, AR-C124910XX from 50 µL human plasma using... -
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- Pharmacokinetics of cisplatin during open and minimally-invasive secondary cytoreductive surgery plus HIPEC in women with platinum-sensitive recurrent ovarian cancer: a prospective study
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Petrillo M, Zucchetti , Cianci S, Morosi L, Ronsini C, Colombo A, D'Incalci , Scambia G, Fagotti A
- KMID: 2450238
- J Gynecol Oncol.
- 2019 Jul;30(4):e59.
- doi: 10.3802/jgo.2019.30.e59
OBJECTIVE: Evidences from animal models seem to suggest that minimally invasive surgery may enhance cisplatin diffusion when the drug is administered in the context of post-operative hyperthermic intraperitoneal chemotherapy (HIPEC).... -
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- Understanding the pharmacokinetics of reversible metabolism
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Cho S, Yoon YR
- KMID: 2457571
- Transl Clin Pharmacol.
- 2019 Jun;27(2):52-58.
- doi: 10.12793/tcp.2019.27.2.52
This tutorial introduces the mathematical skills required to obtain exact and approximate solutions for reversible reactions and provides graphical insights to help understand the pharmacokinetics of reversible metabolism. The matrix... -
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- Effects of CYP1A enzyme specific inhibitor on pharmacokinetics of para-acetaminophen in Bactrian camel
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San R, Yue W, Hasi S
- KMID: 2448701
- J Vet Sci.
- 2019 May;20(3):e12.
- doi: 10.4142/jvs.2019.20.e12
The effects of CYP1A enzyme on the pharmacokinetics of p-acetaminophen were studied in Bactrian camel. Twelve Bactrian camels were divided into 2 groups, then given a single dose of p-acetaminophen... -
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- Pharmacokinetics of enrofloxacin HCl-2Hâ‚‚O (Enro-C) in dogs and pharmacokinetic/pharmacodynamic Monte Carlo simulations against Leptospira spp.
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Sumano H, Ocampo L, Tapia G, Mendoza CD, Gutierrez
- KMID: 2420928
- J Vet Sci.
- 2018 Sep;19(5):600-607.
- doi: 10.4142/jvs.2018.19.5.600
Pharmacokinetic/pharmacodynamic (PK/PD) ratios of reference enrofloxacin (Enro-R) and enrofloxacin as HCl-2H₂O (Enro-C), as well as Monte Carlo simulations based on composite MIC₅₀ and MIC₉₀ (MIC, minimum inhibitory concentration) vs. Leptospira... -
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- Effect of plasma membrane monoamine transporter genetic variants on pharmacokinetics of metformin in humans
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Moon SJ, Oh J, Lee SH, Choi Y, Yu KS, Chung JY
- KMID: 2413831
- Transl Clin Pharmacol.
- 2018 Jun;26(2):79-85.
- doi: 10.12793/tcp.2018.26.2.79
Metformin, an oral hypoglycemic agent belonging to biguanide class, is widely used to treat type 2 diabetes mellitus, and several drug transporters such as organic cation transporters (OCTs), multidrug and... -
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- Pharmacokinetics comparison of solifenacin tartrate and solifenacin succinate: a randomized, open-label, single-dose, 2-way crossover study in healthy male volunteers
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Kim YM, Jeon JY, Moon SJ, Jung J, Son H, Kim MG
- KMID: 2413830
- Transl Clin Pharmacol.
- 2018 Jun;26(2):73-78.
- doi: 10.12793/tcp.2018.26.2.73
Solifenacin is a muscarinic antagonist indicated for the treatment of overactive bladder with symptoms. Solifenacin tartrate is a newly developed salt formulation of solifenacin. This study compared the pharmacokinetic and... -
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- Pharmacokinetics of fixed-dose combination of rosuvastatin 20 mg and ezetimibe 10 mg compared to concurrent administration of individual tablets in healthy Korean subjects
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Hwang I, Park SI, Lee S, Lee B, Yu KS, Jeon JY, Kim MG
- KMID: 2420303
- Transl Clin Pharmacol.
- 2018 Mar;26(1):16-24.
- doi: 10.12793/tcp.2018.26.1.16
This study aimed to compare the pharmacokinetics of fixed-dose combination (FDC) tablet of rosuvastatin 20 mg/ezetimibe 10 mg with that of concurrent administration of individual rosuvastatin 20 mg tablet and... -
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- Understanding the pharmacokinetics of prodrug and metabolite
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Cho S, Yoon YR
- KMID: 2420300
- Transl Clin Pharmacol.
- 2018 Mar;26(1):1-5.
- doi: 0.12793/tcp.2018.26.1.1
This tutorial explains the pharmacokinetics of a prodrug and its active metabolite (or parent drug) using a two-step, consecutive, first-order irreversible reaction as a basic model for prodrug metabolism. In... -
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- Comparison of pharmacokinetics and safety of fixed-dose combination of SKI306X and aceclofenac versus separate tablets in healthy subjects
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Meng X, Oh ES, Park MS, Kim D, Kim JH, Kim CO
- KMID: 2407002
- Transl Clin Pharmacol.
- 2017 Dec;25(4):196-201.
- doi: 10.12793/tcp.2017.25.4.196
JOINS (SKI306X) is an herbal anti-arthritic medicine that is widely used with aceclofenac for treating osteoarthritis in Korea. A fixed-dose combination (FDC) tablet containing SKI306X and aceclofenac was developed to... -
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- Pharmacokinetics of atorvastatin and sustained-release metformin fixed-dose combination tablets: two randomized, open-label, 2-way crossover studies in healthy male subjects under fed conditions
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Choi YK, Park SE, Kim EY, Park HJ, Kim EJ, Song GS, Ghim JL
- KMID: 2407001
- Transl Clin Pharmacol.
- 2017 Dec;25(4):190-195.
- doi: 10.12793/tcp.2017.25.4.190
Two separate studies were conducted to establish bioequivalence (BE) for two doses of atorvastatin/metformin sustained-release (SR) fixed dose combination (FDC) versus the same dosage of the individual component (IC) tablets... -
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- Screening study for genetic polymorphisms affecting pharmacokinetics of talniflumate
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Jin LH, Kim BH, Lee JH, Lee K, Kwack K, Yim SV
- KMID: 2406997
- Transl Clin Pharmacol.
- 2017 Dec;25(4):166-172.
- doi: 10.12793/tcp.2017.25.4.166
Talniflumate is a phthalidyl ester of niflumic acid, which has potent analgesic and anti-inflammatory effects and is widely used to treat inflammatory disorders, such as rheumatoid arthritis. To screen the... -
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- Pharmacokinetics of tilmicosin in healthy pigs and in pigs experimentally infected with Haemophilus parasuis
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Zhang L, Zhao L, Liu Y, Liu J, Li X
- KMID: 2398501
- J Vet Sci.
- 2017 Dec;18(4):431-437.
- doi: 10.4142/jvs.2017.18.4.431
A comparative in vivo pharmacokinetic (PK) study of tilmicosin (TIL) was conducted in 6 crossbred healthy pigs and 6 crossbred pigs infected with Haemophilus (H.) parasuis following oral administration of... -
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- Role of the ABCB1 Drug Transporter Polymorphisms in the Pharmacokinetics of Oseltamivir in Humans: a Preliminary Report
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Cha YJ, Ghim JL
- KMID: 2385963
- J Korean Med Sci.
- 2017 Sep;32(9):1542-1547.
- doi: 10.3346/jkms.2017.32.9.1542
Oseltamivir is a substrate of P-glycoprotein, an efflux drug transporter encoded by ABCB1. The objective of this study was to assess the role of ABCB1 (c.1236C>T, c.2677G>T/A, and c.3435C>T) polymorphisms... -
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- Pharmacokinetics and drug therapy in neonates
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Cho HJ
- KMID: 2385909
- Pediatr Emerg Med J.
- 2017 Jun;4(1):5-11.
- doi: 10.22470/pemj.2017.00059
Neonates include both full term and preterm infants up to 28 days of age. The heterogeneity and rapid physiologic change of neonates affect all aspects of pharmacokinetics such as absorption,... -
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- Clinical Pharmacokinetics of Caffeine in Korean Preterm Infants with Apnea of Prematurity
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Lim MS, Son MJ, Shin JE, Lee SM, Eun HS, Park MS, Park KI, Namgung R
- KMID: 2371411
- Neonatal Med.
- 2017 Feb;24(1):20-25.
- doi: 10.5385/nm.2017.24.1.20
PURPOSE: Caffeine shows wide interindividual pharmacokinetic (PK) variation, and therapeutic drug monitoring (TDM) may be needed. The PK profile of caffeine in Korean preterm neonates was investigated, and factors influencing... -
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- Experience and pharmacokinetics of Levetiracetam in Korean neonates with neonatal seizures
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Shin JW, Jung YS, Park K, Lee SM, Eun HS, Park MS, Park KI, Namgung R
- KMID: 2371378
- Korean J Pediatr.
- 2017 Feb;60(2):50-54.
- doi: 10.3345/kjp.2017.60.2.50
PURPOSE: The aims of this study were to evaluate the safety and pharmacokinetics of levetiracetam (LEV) in neonates with seizures and to establish a population pharmacokinetics (PPK) model by using... -
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