J Vet Sci.  2005 Jun;6(2):147-150.

Pharmacokinetics and dosage regimen of ceftriaxone in E. coli lipopolysaccharide induced fever in buffalo calves

Affiliations
  • 1Department of Pharmacology and Toxicology, College of Veterinary Sciences, Punjab Agricultural University, Ludhiana-141004, India. guggujalajan@yahoo.co.in
  • 2Faculty of Veterinary and Animal Husbandry, Sher-e-Kashmir University Agricultural Science Technology, R.S. Pura, Jammu-181102, India.

Abstract

The present study was planned to investigate the pharmacokinetics of ceftriaxone in experimentally induced febrile buffalo calves (n = 5). The fever was induced by intravenous injection of E.coli lipopolysaccaride (1 microgram/kg). To study the pharmacokinetics, ceftriaxone was administered at the dose rate of 10 mg/kg body wt. in all animals. At 1 min, the peak concentration of ceftriaxone was 79.4 +/- 2.37 microgram/ml and the drug was detected up to 6 h. The elimination rate constant was 0.35 +/- 0.02 /h and elimination half-life was 2.04 +/- 0.14 h. The apparent volume of distribution (Vd(area)) and total body clearance (ClB) were 1.21 +/- 0.15 l/kg and 0.41 +/- 0.03 l/kg/h, respectively. To maintain a minimum therapeutic concentration of 1 microgram/kg, a satisfactory dosage regimen of cefriaxone in febrile buffalo calves is 19 mg/kg followed by 18 mg/kg at 8 h intervals.

Keyword

buffalo calf; ceftriaxone; dosage regimen; febrile; pharmacokinetics
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