- Effects of Hydrogen Sulfide and Nitric Oxide on the Permeability of Cultured Trabecular Meshwork Cells
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Son MS, Baek MJ, Kim JW
- KMID: 2471767
- J Korean Ophthalmol Soc.
- 2020 Mar;61(3):267-273.
- doi: 10.3341/jkos.2020.61.3.267
PURPOSE: To investigate the effects of hydrogen sulfide (Hâ‚‚S) on the permeability of a cultured human trabecular meshwork cells (HTMC) monolayer and its interaction with nitric oxide (NO). METHODS: After exposing... -
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- Minocycline and Its Impact on Microbial Dysbiosis in the Skin and Gastrointestinal Tract of Acne Patients
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Thompson K, Rainer BM, Antonescu , Florea L, Mongodin E, Kang S, Chien AL
- KMID: 2467197
- Ann Dermatol.
- 2020 Feb;32(1):21-30.
- doi: 10.5021/ad.2020.32.1.21
BACKGROUND: Associations between acne and gastrointestinal comorbidities suggest that microbial dysbiosis and intestinal permeability may promote inflammatory acne, a condition often managed with oral antibiotics. OBJECTIVE: We performed a case-control study... -
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- Analysis of interaction between intracellular spermine and transient receptor potential canonical 4 channel: multiple candidate sites of negatively charged amino acids for the inward rectification of transient receptor potential canonical 4
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Kim J, Moon SH, Kim T, Ko J, Jeon YK, Shin YC, Jeon JH, So I
- KMID: 2466574
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):101-110.
- doi: 10.4196/kjpp.2020.24.1.101
Transient receptor potential canonical 4 (TRPC4) channel is a nonselective calcium-permeable cation channels. In intestinal smooth muscle cells, TRPC4 currents contribute more than 80% to muscarinic cationic current (mIcat). With... -
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- Particulate Matter 2.5 Causes Deficiency in Barrier Integrity in Human Nasal Epithelial Cells
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Xian M, Ma S, Wang K, Lou H, Wang Y, Zhang L, Wang C, Akdis CA
- KMID: 2462572
- Allergy Asthma Immunol Res.
- 2020 Jan;12(1):56-71.
- doi: 10.4168/aair.2020.12.1.56
PURPOSE: The effect of air pollution-related particulate matter (PM) on epithelial barrier function and tight junction (TJ) expression in human nasal mucosa has not been studied to date. This study... -
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- In Vitro Effects of Plasma Collected From Rats Administered Naftopidil on Whole Urinary Bladder Preparation Isolated From Rats
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Hattori T, Sugaya K, Nishijima , Kadekawa K, Ueda T, Yamamoto H
- KMID: 2468713
- Int Neurourol J.
- 2019 Dec;23(4):277-286.
- doi: 10.5213/inj.1938102.051
PURPOSE: Alpha-1-adrenoceptor blockers (e.g., naftopidil) are prescribed for the treatment of male lower urinary tract symptoms. Although the mechanism of action of naftopidil has been studied in various organs, that... -
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- Bowel Wall Thickness, Elasticity, Intestinal Permeability, and Inflammatory Cytokines in Patients with Cirrhosis and Ascites
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Lee SH, Kwon HJ, Kim NH, Kim HJ, Cho YK, Jeon WK, Park EH, Kim BI
- KMID: 2467217
- Korean J Med.
- 2019 Dec;94(6):511-518.
- doi: 10.3904/kjm.2019.94.6.511
BACKGROUND/AIMS: Previous studies have reported that endotoxemia is associated with pathogenesis and complications in cirrhosis. Endotoxin stimulates the secretion of inflammatory cytokines, which contributes to the development of complications. In... -
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- Effect and Mechanism of Phosphodiesterase Inhibitors on Trabecular Outflow
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Kim JW, Lee JB, Lee SH
- KMID: 2459522
- Korean J Ophthalmol.
- 2019 Oct;33(5):414-421.
- doi: 10.3341/kjo.2019.0057
PURPOSE: Phosphodiesterase (PDE) inhibitors increase matrix metalloproteinase (MMP) production by inhibiting re-uptake of adenosine and may potentiate nitric oxide (NO) activity. This study was performed to investigate the effects and... -
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- Cyclosporin A aggravates hydrogen peroxide-induced cell death in kidney proximal tubule epithelial cells
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Moon D, Kim J
- KMID: 2459547
- Anat Cell Biol.
- 2019 Sep;52(3):312-323.
- doi: 10.5115/acb.18.192
Cyclosporin A (CsA) does not only exert a toxic effect on kidney parenchymal cells, but also protects them against necrotic cell death by inhibiting opening of mitochondrial permeability transition pore.... -
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- Arg-Leu-Tyr-Glu Suppresses Retinal Endothelial Permeability and Choroidal Neovascularization by Inhibiting the VEGF Receptor 2 Signaling Pathway
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Park W, Baek YY, Kim J, Jo DH, Choi S, Kim JH, Kim T, Kim S, Park M, Kim JY, Won MH, Ha KS, Kim JH, Kwon YG, Kim YM
- KMID: 2456222
- Biomol Ther.
- 2019 Sep;27(5):474-483.
- doi: 10.4062/biomolther.2019.041
Vascular endothelial growth factor (VEGF) plays a pivotal role in pathologic ocular neovascularization and vascular leakage via activation of VEGF receptor 2 (VEGFR2). This study was undertaken to evaluate the... -
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- Health effects and consultations about radon exposure
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Seo S, Kang JK, Lee D, Jin YW
- KMID: 2452640
- J Korean Med Assoc.
- 2019 Jul;62(7):376-382.
- doi: 10.5124/jkma.2019.62.7.376
Radon is a naturally occurring radioactive material classified as a carcinogen by the World Health Organization, and is known to be the factor with the second-greatest impact on lung cancer... -
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- New insights into the transcriptional regulation of aquaporin-2 and the treatment of X-linked hereditary nephrogenic diabetes insipidus
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Jung HJ, Kwon TH
- KMID: 2451864
- Kidney Res Clin Pract.
- 2019 Jun;38(2):145-158.
- doi: 10.23876/j.krcp.19.002
The kidney collecting duct (CD) is a tubular segment of the kidney where the osmolality and final flow rate of urine are established, enabling urine concentration and body water homeostasis.... -
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- Tenovin-1 Induces Senescence and Decreases Wound-Healing Activity in Cultured Rat Primary Astrocytes
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Bang M, Ryu O, Kim DG, Mabunga DF, Cho KS, Kim Y, Han SH, Kwon KJ, Shin CY
- KMID: 2447855
- Biomol Ther.
- 2019 May;27(3):283-289.
- doi: 10.4062/biomolther.2018.107
Brain aging induces neuropsychological changes, such as decreased memory capacity, language ability, and attention; and is also associated with neurodegenerative diseases. However, most of the studies on brain aging are... -
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- Dynamic Contrast-Enhanced Ultrasound of Gastric Cancer: Correlation with Perfusion CT and Histopathology
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Joo I, Kim SH, Lee DH, Han JK
- KMID: 2442712
- Korean J Radiol.
- 2019 May;20(5):781-790.
- doi: 10.3348/kjr.2018.0273
OBJECTIVE: To assess the relationship between contrast-enhanced ultrasound (CEUS) parameters and perfusion CT (PCT) parameters of gastric cancers and their correlation with histologic features. MATERIALS AND METHODS: This prospective study was... -
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- Tweety-homolog (Ttyh) Family Encodes the Pore-forming Subunits of the Swelling-dependent Volume-regulated Anion Channel (VRAC(swell)) in the Brain
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Han YE, Kwon J, Won J, An H, Jang MW, Woo J, Lee JS, Park MG, Yoon BE, Lee SE, Hwang EM, Jung JY, Park H, Oh SJ, Lee CJ
- KMID: 2450213
- Exp Neurobiol.
- 2019 Apr;28(2):183-215.
- doi: 10.5607/en.2019.28.2.183
In the brain, a reduction in extracellular osmolality causes water-influx and swelling, which subsequently triggers Clâ»- and osmolytes-efflux via volume-regulated anion channel (VRAC). Although LRRC8 family has been recently proposed... -
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- Circulating Permeability Factors in Idiopathic Nephrotic Syndrome
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Ha TS
- KMID: 2448157
- Child Kidney Dis.
- 2019 Apr;23(1):7-21.
- doi: 10.3339/jkspn.2019.23.1.7
Nephrotic syndrome (NS) is a common chronic glomerular disease in children characterized by significant proteinuria with resulting hypoalbuminemia, edema, and hyperlipidemia. Renal biopsy findings of diffuse foot processes effacement on... -
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- Anti-inflammatory effect of Lycium barbarum on polarized human intestinal epithelial cells
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Lee SR, Hwang HJ, Yoon JG, Bae EY, Goo KS, Cho SJ, Cho JA
- KMID: 2442366
- Nutr Res Pract.
- 2019 Apr;13(2):95-104.
- doi: 10.4162/nrp.2019.13.2.95
BACKGROUND/OBJECTIVES: Inflammatory Bowel Disease (IBD) has rapidly escalated in Asia (including Korea) due to increasing westernized diet patterns subsequent to industrialization. Factors associated with endoplasmic reticulum (ER) stress are demonstrated... -
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- Prediction of Treatment Outcome of Chemotherapy Using Perfusion Computed Tomography in Patients with Unresectable Advanced Gastric Cancer
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Lee DH, Kim SH, Lee SM, Han JK
- KMID: 2440482
- Korean J Radiol.
- 2019 Apr;20(4):589-598.
- doi: 10.3348/kjr.2018.0306
OBJECTIVE: To evaluate whether data acquired from perfusion computed tomography (PCT) parameters can aid in the prediction of treatment outcome after palliative chemotherapy in patients with unresectable advanced gastric cancer... -
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- Brain-Gut-Microbiota Axis in Alzheimer's Disease
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Kowalski K, Mulak A
- KMID: 2433497
- J Neurogastroenterol Motil.
- 2019 Jan;25(1):48-60.
- doi: 10.5056/jnm18087
Disturbances along the brain-gut-microbiota axis may significantly contribute to the pathogenesis of neurodegenerative disorders. Alzheimer's disease (AD) is the most frequent cause of dementia characterized by a progressive decline in... -
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- Brain consequences of acute kidney injury: Focusing on the hippocampus
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Malek M
- KMID: 2447176
- Kidney Res Clin Pract.
- 2018 Dec;37(4):315-322.
- doi: 10.23876/j.krcp.18.0056
The high mortality rates associated with acute kidney injury are mainly due to extra-renal complications that occur following distant-organ involvement. Damage to these organs, which is commonly referred to as... -
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- Ethanol changes atpB gene expression and proton permeability in Streptococcus mutans
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Cho CM, Park YJ, Lee SA, Kim JB, Kang JS
- KMID: 2430546
- J Korean Acad Oral Health.
- 2018 Dec;42(4):224-228.
- doi: 10.11149/jkaoh.2018.42.4.224
OBJECTIVES: As a first step to study the anticaries effect of ethanol alone, we investigated the effects of ethanol on the expression levels of the atpB gene and proton permeability... -
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