Korean J Phys Anthropol.  2004 Jun;17(2):99-107.

Inhibitory Effect of Rubus coreanus on Compound 48/80-induced Anaphylactic Shock and Vascular Permeability in Vivo

Affiliations
  • 1Department of Anatomy and Research Center for Allergic Immunologic Disease, Chonbuk National University Medical School, Jeonju, Korea. asch@chonbuk.ac.kr

Abstract

As an attempt to search for antiallergic and antiinflammatory activities, we examined he potency of Rubus coreanus water extract (RCWE). The effect of RCWE on systemic anaphylactic shock and vascular permeability was investigated. Results are 1) compound 48/40-induced mortality rate in mice were significantly inhibited by pretreatment of RCWE and compound 48/40-induced mean death time in mice were delayed by pretreatment of RCWE, 2) compound 48/40-induced mesenteric mast cell degranulation in mice were significantly inhibited by pretreatment of RCWE, 3) the increase of vascular permeability induced by compound 48/80 or anti-DNP IgE in rat was significantly inhibited by pretreatment of RCWE. These results suggest that RCWE contains substances with an activity to inhibit the systemic anaphylaxis and vascular permeability.

Keyword

Anaphylactic shock; Mast cell; Rubus coreanus; Vascular permeability
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