- KRAS Mutation Detection in Non-small Cell Lung Cancer Using a Peptide Nucleic Acid-Mediated Polymerase Chain Reaction Clamping Method and Comparative Validation with Next-Generation Sequencing
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Lee B, Lee B, Han G, Kwon MJ, Han J, Choi YL
- KMID: 1978941
- Korean J Pathol.
- 2014 Apr;48(2):100-107.
BACKGROUND: KRAS is one of commonly mutated genetic "drivers" in non-small cell lung cancers (NSCLCs). Recent studies indicate that patients with KRAS-mutated tumors do not benefit from adjuvant chemotherapy, so... -
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- Evaluation of Peptide Nucleic Acid Probe-Based Fluorescence In Situ Hybridization for the Detection of Mycobacterium tuberculosis Complex and Nontuberculous Mycobacteria in Clinical Respiratory Specimens
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Lee SH, Kim SY, Kim HH, Lee EY, Chang CL
- KMID: 1971110
- Ann Clin Microbiol.
- 2015 Jun;18(2):37-43.
- doi: 10.5145/ACM.2015.18.2.37
BACKGROUND: Tuberculosis is globally the most important cause of death from single pathogen. Rapid and accurate identification of mycobacteria is essential for the control of tuberculosis. We evaluated a fluorescence... -
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- Peptide Nucleic Acid Probe-Based Analysis as a New Detection Method for Clarithromycin Resistance in Helicobacter pylori
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Jung DH, Kim JH, Jeong SJ, Park SY, Kang IM, Lee KH, Song YG
- KMID: 2427454
- Gut Liver.
- 2018 Nov;12(6):641-647.
- doi: 10.5009/gnl18111
BACKGROUND/AIMS: Helicobacter pylori eradication rates are decreasing because of increases in clarithromycin resistance. Thus, finding an easy and accurate method of detecting clarithromycin resistance is important. METHODS: We evaluated 70 H.... -
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- Detection of BRAFV600E Mutations in Papillary Thyroid Carcinomas by Peptide Nucleic Acid Clamp Real-Time PCR: A Comparison with Direct Sequencing
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Jeong D, Jeong Y, Lee S, Lee H, Lee W, Kim H, Park D, Park S, Mu W, Cho HD, Oh MH, Lee SS, Yang SH, Kim CJ
- KMID: 1439780
- Korean J Pathol.
- 2012 Feb;46(1):61-67.
- doi: 10.4132/KoreanJPathol.2012.46.1.61
BACKGROUND: Papillary thyroid carcinoma (PTC) of the thyroid is the most common endocrine malignancy. High prevalence of an activating point mutation of BRAF gene, BRAFV600E, has been reported in PTC.... -
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- Evaluation of Dual-Color Fluorescence In Situ Hybridization With Peptide Nucleic Acid Probes for the Detection of Mycobacterium tuberculosis and Non-Tuberculous Mycobacteria in Clinical Specimens
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Kim N, Lee SH, Yi J, Chang CL
- KMID: 2369765
- Ann Lab Med.
- 2015 Sep;35(5):500-505.
- doi: 10.3343/alm.2015.35.5.500
BACKGROUND: Peptide nucleic acid (PNA) probes are artificial DNA analogues with a hydrophobic nature that can penetrate the mycobacterial cell wall. We evaluated a FISH method for simultaneous detection and... -
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- Rapid and Sensitive Detection of KRAS Mutation by Peptide Nucleic Acid-based Real-time PCR Clamping: A Comparison with Direct Sequencing between Fresh Tissue and Formalin-fixed and Paraffin Embedded Tissue of Colorectal Cancer
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Jeong D, Jeong Y, Lee J, Baek MJ, Kim Y, Lee JH, Cho HD, Oh MH, Kim CJ
- KMID: 1443748
- Korean J Pathol.
- 2011 Apr;45(2):151-159.
- doi: 10.4132/KoreanJPathol.2011.45.2.151
BACKGROUND: Rapid and sensitive detection of KRAS mutation is needed to maximize the benefits for patients who are being treated with monoclonal antibodies to target the epidermal growth factor receptor... -
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- PNA-Mediated PCR Clamping for the Detection of EGFR Mutations in Non-Small Cell Lung Cancer
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Lee KY, Kim HJ, Kim SJ, Yoo GH, Kim WD, Oh SY, Kim WS
- KMID: 2114621
- Tuberc Respir Dis.
- 2010 Oct;69(4):271-278.
- doi: 10.4046/trd.2010.69.4.271
BACKGROUND: Recent studies have demonstrated that the epidermal growth factor receptor (EGFR) genotype is the most important predictive marker to EGFR-tyrosine kinase inhibitors (TKIs) and first-line gefitinib treatment will be... -
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- Peptide Nucleic Acid Clamping Versus Direct Sequencing for the Detection of EGFR Gene Mutation in Patients with Non-small Cell Lung Cancer
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Yoon SH, Choi YD, Oh IJ, Kim KS, Choi H, Chang J, Shin HJ, Park CK, Kim YC
- KMID: 2403384
- Cancer Res Treat.
- 2015 Oct;47(4):661-669.
- doi: 10.4143/crt.2014.282
PURPOSE: Direct sequencing (DS) is the standard method for detection of epidermal growth factor receptor (EGFR) gene mutation in non-small cell lung cancer (NSCLC); however, low detection sensitivity is a... -
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- Peptide Nucleic Acid Clamping and Direct Sequencing in the Detection of Oncogenic Alterations in Lung Cancer: Systematic Review and Meta-Analysis
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Song JU, Lee J
- KMID: 2418783
- Yonsei Med J.
- 2018 Mar;59(2):211-218.
- doi: 10.3349/ymj.2018.59.2.211
PURPOSE: Molecular testing in non-small cell lung cancer (NSCLC) aids in identifying oncogenic alterations. The aim of this study was to compare the rates of detection of oncogenic alterations and... -
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- Comparison of Direct Sequencing, PNA Clamping-Real Time Polymerase Chain Reaction, and Pyrosequencing Methods for the Detection of EGFR Mutations in Non-small Cell Lung Carcinoma and the Correlation with Clinical Responses to EGFR Tyrosine Kinase Inhibitor Treatment
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Lee HJ, Xu X, Kim H, Jin Y, Sun P, Kim JE, Chung JH
- KMID: 1837571
- Korean J Pathol.
- 2013 Feb;47(1):52-60.
BACKGROUND: The aims of this study were to evaluate the abilities of direct sequencing (DS), peptide nucleic acid (PNA) clamping, and pyrosequencing methods to detect epidermal growth factor receptor (EGFR)... -
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- Comparative Analysis of Peptide Nucleic Acid (PNA)-Mediated Real-Time PCR Clamping and DNA Direct Sequencing for EGFR Mutation Detection
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Kim HJ, Kim WS, Shin KC, Lee GH, Kim MJ, Lee JE, Song KS, Kim SY, Lee KY
- KMID: 2319463
- Tuberc Respir Dis.
- 2011 Jan;70(1):21-27.
BACKGROUND: Although the gold standard method for research trials on epidermal growth factor receptor (EGFR) mutations has been direct sequencing, this approach has the limitations of low sensitivity and of... -
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- Evaluation of Peptide Nucleic Acid Probe-based Real-time PCR for Detection of Mycobacterium tuberculosis Complex and Nontuberculous Mycobacteria in Respiratory Specimens
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Choi YJ, Kim HJ, Shin HB, Nam HS, Lee SH, Park JS, Park KS, Baek KA
- KMID: 1380084
- Ann Lab Med.
- 2012 Jul;32(4):257-263.
- doi: 10.3343/alm.2012.32.4.257
BACKGROUND: A peptide nucleic acid (PNA) probe-based real-time PCR (PNAqPCR(TM) TB/NTM detection kit; PANAGENE, Korea) assay has been recently developed for the simultaneous detection of Mycobacterium tuberculosis complex (MTBC) and... -
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- Detection of Plasma BRAF(V600E) Mutation Is Associated with Lung Metastasis in Papillary Thyroid Carcinomas
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Kim BH, Kim IJ, Lee BJ, Lee JC, Kim IS, Kim SJ, Kim WJ, Jeon YK, Kim SS, Kim YK
- KMID: 2450335
- Yonsei Med J.
- 2015 May;56(3):634-640.
- doi: 10.3349/ymj.2015.56.3.634
PURPOSE: The BRAF(V600E) mutation represents a novel indicator of the progression and aggressiveness of papillary thyroid carcinoma (PTC). The purpose of this study was to determine the clinical significance of... -
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