- Enhancement of ATP-induced Currents by Phospholipase D1 Overexpressed in PC12 Cells
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Park JB, Kim YR, Jeon BH, Park SK, Oh SO, Kim YG, Lee SD, Kim KJ
- KMID: 2285291
- Korean J Physiol Pharmacol.
- 2003 Aug;7(4):223-230.
Using phospholipase D1 (PLD1) -overexpressing PC12 (PLD1-PC12) cells, the regulatory roles of PLD1 on ATP-induced currents were investigated. In control and PLD1-PC12 cells, ATP increased PLD activity in an external... -
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- Cytosine Arabinoside-Induced PC12 Cell Death Pathway
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Yang BG, Chai YG, Yang BH
- KMID: 2334571
- J Korean Soc Biol Psychiatry.
- 1998 Nov;5(2):219-226.
Cytosine arabinoside(AraC) inhibits DNA synthesis and beta-DNA polymerase, an enzyme involved in DNA repair. This a potent antimitotic agent, is clinically used as an anticancer drug with side effect of... -
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- Reactive Oxygen Species are Involved in Y-27632-induced Neurite Outgrowth in PC12 Cells
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Park SY, Moon SA, An JM, Kim DS, Seo JT
- KMID: 2368587
- Int J Oral Biol.
- 2016 Dec;41(4):231-236.
- doi: 10.11620/IJOB.2016.41.4.231
Inhibition of Rho-associated coiled coil-containing kinase (ROCK) has been reported to promote differentiation of neuronal cells. Here, we examined the effect of Y-27632, a ROCK inhibitor, on the outgrowth of... -
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- Screening of Low Molecular Metabolite, FS390 as an Inhibitor of Neurotransmitter Release from PC12 Cells
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Chung YT, Kim HJ, Lee YS
- KMID: 1937820
- Korean J Anat.
- 2006 Apr;39(2):91-102.
We established an in vitro experimental system using the following procedure. We first introduced tritium-labeled norepinephrine ([3H]-NE) into PC12 cells. The [3H]-NE incorporated-PC12 cells were stimulated by a high concentration... -
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- Overexpressed Mitochondrial Thioredoxin Protects PC12 Cells from Hydrogen Peroxide and Serum-deprivation
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Lee YS, Yu SA
- KMID: 1607352
- Korean J Physiol Pharmacol.
- 2003 Feb;7(1):33-37.
Oxidative damage to mitochondria is a critical mechanism in necrotic or apoptotic cell death induced by many kinds of toxic chemicals. Thioredoxin (Trx) family proteins are known to play protective... -
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- Sciatic nerve leachate of cattle causes neuronal differentiation of PC12 cells via ERK1/2 signaling pathway
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Zhang Z, Liu Y, Zhu X, Wei L, Zhu J, Shi K, Wang G, Pan L
- KMID: 2417566
- J Vet Sci.
- 2018 Jul;19(4):512-518.
- doi: 10.4142/jvs.2018.19.4.512
Previous studies have shown that the sciatic nerve has neurotrophic activity, and nerve regeneration, differentiation, and axon outgrowth can be modulated by different sciatic nerve preparations. However, numerous animals may... -
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- An Effect of Testesterone on the Proliferation of Artificially Induced Senescent PC12 Pheochromocytoma Cells
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Lee E, Oh CS, Shin DH, Lee YS
- KMID: 2338398
- J Korean Geriatr Soc.
- 2005 Dec;9(4):301-305.
BACKGROUNDS: Although the role of testosterone in the neuroprotection is still poorly known, accumulating evidence suggests that testosterone may be an important role in neurodegenerative disease including dementia. So we... -
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- Differential Inhibition of MPP+- or 6-Hydroxydopamine-induced Cell Viability Loss in PC12 Cells by Trifluoperazine and W-7
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Lee CS
- KMID: 1600082
- Korean J Physiol Pharmacol.
- 2005 Aug;9(4):247-253.
The present study assessed the effect of calmodulin antagonists trifluoperazine and W-7 against the cytotoxicity of MPP+ and 6-hydroxydopamine (6-OHDA) in relation to the mitochondrial dysfunction and cell death in... -
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- The Effects of Psychotropic Drugs on the beta-Amyloid-Induced Cytotoxicity in PC12 Cells
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Kim TS, Lee C, Lee SJ, Toh KY, Kim JJ, Paik IH
- KMID: 2340493
- J Korean Neuropsychiatr Assoc.
- 2000 Sep;39(5):936-943.
OBJECTIVE: Amyloid beta protein(Abeta) has been regarded to be toxic to neurons in vitro. However, the mechanism of action leading to neuronal death remains unknown. In this study, we report... -
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- Lysophosphatidylcholine suppresses apoptosis and induces neurite outgrowth in PC12 cells through activation of phospholipase D2
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Yun DH, Jeon ES, Sung SM, Ryu SH, Kim JH
- KMID: 1110121
- Exp Mol Med.
- 2006 Aug;38(4):375-384.
Lysophosphatidylcholine (LPC) is a bioactive lipid generated by phospholipase A2-mediated hydrolysis of phosphatidylcholine. In the present study, we demonstrate that LPC stimulates phospholipase D2 (PLD2) activity in rat pheochromocytoma PC12... -
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- Involvement of Caspases and Bcl-2 Family in Nitric Oxide-Induced Apoptosis of Rat PC12 Cells
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Jeong YJ, Jung JY, Lee JH, Cho JH, Lee GS, Kim SH, Kim WJ
- KMID: 1587474
- Korean J Physiol Pharmacol.
- 2006 Dec;10(6):329-335.
This study was aimed to investigate the nitric oxide (NO)-induced cytotoxic mechanism in PC12 cells. Sodium nitroprusside (SNP), an NO donor, decreased the viability of PC12 cells in dose- and... -
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- Intracellular Aciditfication Induces PC12 cell Apoptosis Through p38 Kinase Activation
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Bae WY, Chay KO, lee KY
- KMID: 2172396
- Chonnam Med J.
- 2001 Dec;37(4):335-343.
No abstract available. -
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- Ameliorative Effects of Ombuoside on Dopamine Biosynthesis in PC12 Cells
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Davaasambuu U, Park KH, Park HJ, Choi HS, Lee CK, Hwang BY, Lee MK
- KMID: 2416069
- Nat Prod Sci.
- 2018 Jun;24(2):99-102.
- doi: 10.20307/nps.2018.24.2.99
This study investigated the effects of ombuoside, a flavonol glycoside, on dopamine biosynthesis in PC12 cells. Ombuoside at concentrations of 1, 5, and 10 µM increased intracellular dopamine levels at... -
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- Calcium overload is essential for the acceleration of staurosporine-induced cell death following neuronal differentiation in PC12 cells
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Seo SR, Seo JT
- KMID: 1088602
- Exp Mol Med.
- 2009 Apr;41(4):269-276.
- doi: 10.3858/emm.2009.41.4.030
Differentiation of neuronal cells has been shown to accelerate stress-induced cell death, but the underlying mechanisms are not completely understood. Here, we find that early and sustained increase in cytosolic... -
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- Neurotrophic and Neuritogenic Effects of Water Extracts of Rhizoma of Coptis chinensis Franch in PC12 Cells
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Kwon GY, Choe BK, Kim SK
- KMID: 2071593
- Korean J Physiol Pharmacol.
- 2003 Jun;7(3):175-179.
Coptis chinensis (CC) is one of the traditional herbs used in Oriental medicine for the treatment of gastrointestinal disorders, anxiety, and insomnia. In this study, neurotrophic and neuritogenic effects of... -
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- Subcellular Distribution of Microtubule in Artificially Induced Senescent PC12 Cells
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Lee E, Oh CS, Shin DH, Lee YS
- KMID: 2338530
- J Korean Geriatr Soc.
- 2006 Dec;10(4):278-284.
Background: Since recent reports showed the possibility that cytoskeletal proteins, which were known to be exclusively within the cytoplasm, might play a role in the re-distribution of the intranuclear chromatin... -
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- Promoting Effect of Hydrogen Peroxide on 1-Methyl-4-phenylpyridinium-induced Mitochondrial Dysfunction and Cell Death in PC12 Cells
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Lee DH, Lee CS
- KMID: 1512942
- Korean J Physiol Pharmacol.
- 2006 Feb;10(1):51-58.
The promoting effect of hydrogen peroxide (H2O2) against the cytotoxicity of 1-methyl-4-phenylpyridinium (MPP+) in differentiated PC12 cells was assessed by measuring the effect on the mitochondrial membrane permeability. Treatment of... -
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- Expression of Inducible Nitric Oxide Synthase and Nitric Oxide Mediated Apoptosis in Neuronal PC12 Cells after Lipopolysaccharide/Tumor Necrosis Factor-/Interferon- Treatment
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Kim J, Kim J, Kang K, Kwak E, Park J, Park T, Sohn Y
- KMID: 1725913
- Korean J Pathol.
- 2002 Aug;36(4):249-256.
BACKGROUND: Inducible nitric oxide synthase (iNOS) has been detected in a number of pathologic conditions in the central nervous system. This study was investigated the patterns of iNOS expression in... -
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- Mercury induced the Accumulation of Amyloid Beta (Abeta) in PC12 Cells: The Role of Production and Degradation of Abeta
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Song JW, Choi BS
- KMID: 2317841
- Toxicol Res.
- 2013 Dec;29(4):235-240.
Extracellular accumulation of amyloid beta protein (Abeta) plays a central role in Alzheimer's disease (AD). Some metals, such as copper, lead, and aluminum can affect the Abeta accumulation in the... -
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- Enhanced tyrosine hydroxylase expression in PC12 cells co-cultured with feline mesenchymal stem cells
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Jin GZ, Yin XJ, Yu XF, Cho SJ, Lee HS, Lee HJ, Kong IK
- KMID: 1106218
- J Vet Sci.
- 2007 Dec;8(4):377-382.
- doi: 10.4142/jvs.2007.8.4.377
Mesenchymal stem cells (MSCs) secrete a variety of neuroregulatory molecules, such as nerve growth factor, brain-derived neurotrophic factor, and glial cell-derived neurotrophic factor, which upregulate tyrosine hydroxylase (TH) gene expression... -
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