- Novel Drugs for Asthma Treatment: Immunomodulatory Therapy
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Lee JH
- KMID: 2263473
- Korean J Med.
- 2012 Aug;83(2):190-196.
The management of asthma focuses on the reduction of airway inflammation accompany with symptomatic care after recognition. Glucocorticosteroid is the most important drug to reduce airway inflammation, and it has... -
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- Treatment of Atopic Dermatitis: an Update and Review of the Literature
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Kim TY
- KMID: 1474532
- Pediatr Allergy Respir Dis.
- 2009 Sep;19(3):209-219.
Atopic dermatitis is a chronic, relapsing, inflammatory skin disease, with genetic and environmental backgrounds. Successful management of atopic dermatitis requires a multipronged approach. Management should compromise of a disease-adapted treatment... -
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- Control of Scarring in Adult Wounds using Antisense Connective Tissue Growth Factor Ollgodeoxynucleotides
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Chung HT
- KMID: 1550742
- Korean J Immunol.
- 1999 Dec;21(4):311-317.
Adult wounds heal with scar formation, whereas fetal wounds heal without scarring and with a lesser inflammatory and cytokine response. Recently connective tissue growth factor (CTGF) is known to play... -
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- Site-Specific Mutagenesis in Escherichia coli by Bulky Exocyclic Amino-Substituted Guanine and Adenine Derivatives in Double-Stranded or Gapped Plasmids
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Moon KY
- KMID: 1807225
- Cancer Res Treat.
- 2003 Feb;35(1):75-80.
PURPOSE: 7-Bromomethylbenz[alpha]anthracene is a known mutagen and carcinogen. The mutagenic potency of its two major DNA adducts, i.e., N2-(benz[alpha]anthracen-7-ylmethyl)-2'-deoxyguanosine (b[alpha]a2G) and N6-(benz[alpha]anthracen-7-ylmethyl)-2'-deoxyadenosine (b[alpha]a6A), as well as the simpler benzylated analogs,... -
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- Antiviral Effect of Antisense Phosphorothioate Oligonucleotides Targeted to Herpes Simplex Virus
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Lee YC, Kim SJ, Cho YJ
- KMID: 2146905
- J Korean Soc Microbiol.
- 1999 Jun;34(3):233-243.
To search the effective antisense oligonucleotide that inhibit the growth of Herpes simplex virus type 1 (HSV-1), six kinds of phosphorothioate oligodeoxynucleotides (S-ODNs) were synthesized and the antiviral activity was... -
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- Comparison of L1 consensus primers with E6 type specific primers for detection of human papillomaviruses in paraffin sections of cervical neoplasia
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Park JS, Namkoong S, Han SK, Nha DJ, Lee HY, Kim SJ
- KMID: 1421953
- J Korean Med Sci.
- 1993 Feb;8(1):60-67.
- doi: 10.3346/jkms.1993.8.1.60
In our comparative study of L1 consensus primers with E6 type-specific primers for detection of human papillomavirus (HPVs) by polymerase chain reaction (PCR) in 35 cases of cervical neoplasia, the... -
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- Inhibition of Allergic Response by Intranasal Selective NF-κB Decoy Oligodeoxynucleotides in a Murine Model of Allergic Rhinitis
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Wee JH, Zhang YL, Rhee CS, Kim DY
- KMID: 2355895
- Allergy Asthma Immunol Res.
- 2017 Jan;9(1):61-69.
- doi: 10.4168/aair.2017.9.1.61
PURPOSE: It remains unknown whether local inhibition of Nuclear factor-kappa B (NF-κB) could have therapeutic value in the treatment of allergic rhinitis (AR). This study aimed to evaluate the effect... -
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- Antisense Deoxyoligonucleotides Inhibit Activities of Matrix Metalloproteinase-2 in Human Fibrosarcoma HT1080 Cells
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Park JS, Yang DO, Lim SH, Yoo HG, Cho HN, Jung YD, Kim SJ, Chung SS, Shin BA
- KMID: 1568915
- Cancer Res Treat.
- 2002 Dec;34(6):444-449.
PURPOSE: MMP-2, 72 kDa-type IV collagenase, plays a major role in the migration and growth of tumor cells, a process that requires the disintegration of basement membrane. Activation of MMP-2... -
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- Intra-peritoneal NF-kappaB decoy oligodeoxynucleotide decreases postoperative intra-abdominal adhesion
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Ahn BN, Song MH, Kim JH, Kim KH, Park KK, Choi YS
- KMID: 1992620
- Korean J Obstet Gynecol.
- 2012 Apr;55(4):244-249.
- doi: 10.5468/KJOG.2012.55.4.244
OBJECTIVE: The objective of this study was to evaluate the effect of intra-peritoneal nuclear factor kappaB (NF-kappaB) decoy oligodeoxynucleotide on the prevention of postoperative intra-abdominal adhesion. METHODS: Forty female BALB/c mice... -
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- Modulation of Eosinophilia and Cytokines of Bronchoalveolar Larvage Fluid(BALF) by CpG Oligodeoxynucleotides(ODN) in a Mouse Model of Established Airway Inflammation
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Mok JS, Choi SM
- KMID: 1994329
- Pediatr Allergy Respir Dis.
- 2002 Jun;12(2):93-104.
PURPOSE: Asthma is an inflammatory disease of the airways that is induced by Th2 cytokines and inhibited by Th1 cytokines. Oligodeoxynucleotides containing a CpG motif(CpG ODN), as potent inducers of... -
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- Newly Identified TLR9 Stimulant, M6-395 Is a Potent Polyclonal Activator for Murine B Cells
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Park MH, Jung YJ, Kim PH
- KMID: 2014653
- Immune Netw.
- 2012 Feb;12(1):27-32.
- doi: 10.4110/in.2012.12.1.27
BACKGROUND: Toll-like receptors (TLRs) have been extensively studied in recent years. However, functions of these molecules in murine B cell biology are largely unknown. A TLR4 stimulant, LPS is well... -
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- The Effect of Ribbon-Type Antisense Oligodeoxynucleotides for Transforming Growth Factor-beta1 in Unilateral Ureteral Obstruction
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Han SM, Kim EJ, Jeoung HS, Lee BY, Lee SS, Park KK, Kim HC
- KMID: 2073725
- Korean J Pathol.
- 2002 Apr;36(2):84-92.
BACKGROUND: In unilateral ureteral obstruction (UUO), the obstructed kidney is characterized by interstitial fibrosis and an increase in transforming growth factor (TGF)-beta1. Interstitial expression of TGF-beta1 is important in tublointerstitial... -
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- Metabolic Phenotype of Glycogen Synthase Gene Inhibition in Human Skeletal Muscle Cells
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Koh JJ, Park KS, Kim JM, Kim SY, Lee HK, Ciaraldi T, Henry RR
- KMID: 1539950
- J Korean Diabetes Assoc.
- 2000 Jun;24(3):331-339.
BACKGROUND: Glycogen synthase (GS) is the rate-limiting enzyme controlling non-oxidative glucose disposal in skeletal muscle. Reduction in GS activity and impaired insulin responsiveness are characteristic features of skeletal muscle in... -
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- Effect of CpG Oligodeoxynucleotides on Airways of Mice with Established Airways Inflammation
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Hwang HW, Kim SJ, Kim WD, Cho SM, Lee DS, Choi SM
- KMID: 2335653
- J Korean Pediatr Soc.
- 2002 Jul;45(7):875-883.
PURPOSE: Airways eosinophilia and increased IgE, characteristic features of asthma, result from a predominant Th2 response. In this study, we investigated the effect of CpG oligodeoxynucleotides (ODNs) on the inhibition... -
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- Toll-like receptor 9 expression and interferon-alpha secretion upon CpG-ODN stimulation in allergic subjects
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Han MY, Jee HM, Kim HY, Lee CA, Cho HJ, Hwang SG, Kim KE
- KMID: 2281257
- Korean J Pediatr.
- 2009 Sep;52(9):1015-1020.
- doi: 10.3345/kjp.2009.52.9.1015
PURPOSE: The aim of this study is to explore the effect of the Toll-like receptor 9 (TLR9) expressed in plasmacytoid dendritic cells (pDCs) that respond to antigen to Th2 immune... -
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- Effect of Cytosine-phosphate-Guanine Oligodeoxynucleotides on Airway Hyperresponsiveness and Inflammation of Repeated Respiratory Syncytial Virus Infection in a Mouse Model
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- KMID: 2146024
- Korean J Asthma Allergy Clin Immunol.
- 2010 Jun;30(2):123-130.
BACKGROUND: Severe respiratory syncytial virus (RSV) infection in neonate has been reported as a risk factor for the development of allergic asthma or early transient wheezing. RSV can induce reinfection... -
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- Effect of Transcription Factor Decoy for NF-κB on the TNF-α Induced Cytokine and ICAM-1 Expression in Cultured HaCaT cells
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Lee KS, Kim JO, Kim BC, Ryoo YW
- KMID: 2362392
- Ann Dermatol.
- 2003 Sep;15(3):93-98.
- doi: 10.5021/ad.2003.15.3.
BACKGROUND: Psoriasis is the most prevalent T-cell-mediated inflammatory skin disease in humans. Numerous cytokines and adhesion molecules are expressed in the skin lesion of psoriasis such as TNF-α, IL-1, IL-6,... -
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- Rat Organic Anion Transporter 3 Co-localized with Caveolin-2 in Rat Kidney
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Kim HW, Kwak JO, Kim MJ, Lee SW, Jung SM, Gwak HK, Cha SH
- KMID: 2079491
- Korean J Nephrol.
- 2005 Jul;24(4):537-548.
BACKGROUND: The recently identified organic anion transporter 3 (rOAT3) was mainly expressed in kidney, liver and brain tissue, and it contributes the movement of endogenous or exogenous substances across the... -
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- Modulation of Antibody Responses against Gnathostoma spinigerum in Mice Immunized with Crude Antigen Formulated in CpG Oligonucleotide and Montanide ISA720
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Intapan PM, Hirunpetcharat C, Kularbkaew C, Yutanawiboonchai W, Janwan P, Maleewong
- KMID: 1712215
- Korean J Parasitol.
- 2013 Dec;51(6):637-644.
- doi: 10.3347/kjp.2013.51.6.637
This study aimed to investigate the antibody responses in mice immunized with Gnathostoma spinigerum crude antigen (GsAg) incorporated with the combined adjuvant, a synthetic oligonucleotide containing unmethylated CpG motif (CpG... -
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- Plasminogen Activator Inhibitor-1 Antisense Oligodeoxynucleotides Abrogate Mesangial Fibronectin Accumulation
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Park J, Seo JY, Ha H
- KMID: 2071710
- Korean J Physiol Pharmacol.
- 2010 Dec;14(6):385-390.
- doi: 10.4196/kjpp.2010.14.6.385
Excessive extracellular matrix (ECM) accumulation is the main feature of chronic renal disease including diabetic nephropathy. Plasminogen activator inhibitor (PAI)-1 is known to play an important role in renal ECM... -
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