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c-Fos Immunoreactivity in the Neurons of the Lateral Geniculate Nucleus in Albino Rats by Light Exposure after Dark Rearing

Cha YJ, Lee JH, Baik TK, Park JS

PURPOSE: To investigate the effect of dark rearing immediately after birth on the maturation of the visual relay neurons in the lateral geniculate nucleus. METHODS: Fifty neonatal rats were used. Neonates...
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Downregulation of neurotrophic factors in the brain of a mouse model of Gaucher disease: implications for neuronal loss in Gaucher disease

Kim EY, Hong YB, Go SH, Lee B, Jung SC

  • KMID: 1110118
  • Exp Mol Med.
  • 2006 Aug;38(4):348-356.
Gaucher disease is a glycosphingolipid storage disease caused by deficiency of glucocerebrosidase, resulting in the accumulation of glucosylceramide in lysosomes. The neuronopathic forms of this disease are associated with neuronal...
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Corticotropin-releasing Factor (CRF) and Urocortin Promote the Survival of Cultured Cerebellar GABAergic Neurons Through the Type 1 CRF Receptor

Choi JS, Pham T, Jang YJ, Bui BC, Lee BH, Joo KM, Cha CI, Lee KH

Corticotropin releasing factor (CRF) is known to be involved in the stress response and in some degenerative brain disorders. In addition, CRF has a role as a neuromodulator in adult...
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Dopamine promotes formation and secretion of non-fibrillar alpha-synuclein oligomers

Lee HJ, Baek SM, Ho DH, Suk JE, Cho ED, Lee SJ

Parkinson's disease (PD) is characterized by selective and progressive degeneration of dopamine (DA)-producing neurons in the substantia nigra pars compacta (SNpc) and by abnormal aggregation of alpha-synuclein. Previous studies have...
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Efficacy of Anti-NaV1.7 Antibody on the Sensory Nervous System in a Rat Model of Lumbar Intervertebral Disc Injury

Nojima D, Inage K, Sakuma Y, Sato J, Orita S, Yamauchi K, Eguchi Y, Ochiai N, Kuniyoshi , Aoki Y, Nakamura J, Miyagi M, Suzuki M, Kubota G, Sainoh T, Fujimoto K, Shiga Y, Abe K, Kanamoto H, Inoue G, Takahashi , Ohtori S

PURPOSE: The pathophysiology of discogenic low back pain is not fully understood. Tetrodotoxin-sensitive voltage-gated sodium (NaV) channels are associated with primary sensory nerve transmission, and the NaV1.7 channel has emerged...
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Expression of tyrosine kinase A in the cerebral cortex of postnatal developing rat

Kwon HJ, Lee KY, Park IK, Park MS, Lee MY, Kim MK

  • KMID: 1091197
  • J Vet Sci.
  • 2005 Sep;6(3):185-189.
Tyrosine kinase A (TrkA)is an essential component of the high affinity nerve growth factor (NGF) receptor necessary to the mediate the biological effects of the neurotrophins, NGF. This study examined...
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Calcium-influx increases SOD1 aggregates via nitric oxide in cultured motor neurons

Kim HJ, Im W, Kim S, Kim SH, Sung JJ, Kim M, Lee KW

  • KMID: 1090960
  • Exp Mol Med.
  • 2007 Oct;39(5):574-582.
Familial amyotrophic lateral sclerosis (fALS) is caused by mutations in Cu/Zn-superoxide dismutase (SOD1), and SOD1 aggregation and calcium toxicity are involved in neuronal death. However, the effect of altered calcium...
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Increased expression of the receptor for advanced glycation end products in neurons and astrocytes in a triple transgenic mouse model of Alzheimer's disease

Choi BR, Cho WH, Kim J, Lee HJ, Chung C, Jeon WK, Han JS

The receptor for advanced glycation end products (RAGE) has been reported to have a pivotal role in the pathogenesis of Alzheimer's disease (AD). This study investigated RAGE levels in the...
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Upregulation of Glutamate Receptors in Rat Cerebral Cortex with Neuronal Migration Disorders

Lee MC, Shim JJ, Kim JH, Kim MK, Woo YJ, Chung WK, Suh JJ, Nam SC, Lee JS, Kim YS, Kim JH, Kim HI

Neuronal migration disorders (NMDs) constitute the main pathologic substrate of medically intractable epilepsy in human. This study is designed to investigate the changes in expression of glutamate receptor subtypes on...
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Gephyrin: a central GABAergic synapse organizer

Choii G, Ko J

Gephyrin is a central element that anchors, clusters and stabilizes glycine and gamma-aminobutyric acid type A receptors at inhibitory synapses of the mammalian brain. It self-assembles into a hexagonal lattice...
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Human SNF2L Gene Is Regulated Constitutively and Inducibly in Neural Cells via a cAMP-Response Element

Xia Y, Wang L, Ma C, Gong Y, Zhao Y

PURPOSE: SNF2L belongs to Imitation Switch family and plays an essential role in neural tissues and gonads. In our previous studies, we have demonstrated that the basal transcription of human...
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Toward understanding the role of the neuron-specific BAF chromatin remodeling complex in memory formation

Choi KY, Yoo M, Han JH

The long-term storage of memory requires the finely tuned coordination of intracellular signaling with the transcriptional, translational and epigenetic regulations of gene expression. Among the epigenetic mechanisms, however, we know...
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N-acetyl-D-glucosamine kinase interacts with dynein light-chain roadblock type 1 at Golgi outposts in neuronal dendritic branch points

Islam MA, Sharif SR, Lee H, Seog DH, Moon IS

N-acetylglucosamine kinase (GlcNAc kinase or NAGK) is a ubiquitously expressed enzyme in mammalian cells. Recent studies have shown that NAGK has an essential structural, non-enzymatic role in the upregulation of...
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beta1-integrin-dependent migration of microglia in response to neuron-released alpha-synuclein

Kim C, Cho ED, Kim HK, You S, Lee HJ, Hwang D, Lee SJ

Chronic neuroinflammation is an integral pathological feature of major neurodegenerative diseases. The recruitment of microglia to affected brain regions and the activation of these cells are the major events leading...
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Low Dose Radiation Overcomes Diabetes-induced Suppression of Hippocampal Neuronal Cell Proliferation in Rats

Kang JO, Kim SK, Hong SE, Lee TH, Kim CJ

We investigated the effect of low dose radiation on diabetes induced suppression of neurogenesis in the hippocampal dentate gyrus of rat. After 0.01 Gy, 0.1 Gy, 1 Gy and 10...
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