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Photodynamic Therapy for Subretinal New Vessels

Lee SC, Bae JH, Koh HJ, Kim SS, Kwon OW

Photodynamic therapy (PDT) involves the induction of endothelial cell death or occlusion of blood vessels. On the basis of this mechanism of action, PDT is used in the treatment of...
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Leucine-rich G Protein-coupled Receptor-5 Is Significantly Increased in the Aqueous Humor of Human Eye with Proliferative Diabetic Retinopathy

Hong EH, Hwang M, Shin YU, Park HH, Koh SH, Cho H

Leucine-rich G protein-coupled receptor-5 (LGR5) is known to be a stem cell marker in many organs. LGR5 may have important roles in proliferative diabetic retinopathy (PDR) because LGR5 potentiate the...
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Expression of leptin receptor (Ob-R) in human atherosclerotic lesions: potential role in intimal neovascularization

Kang SM, Kwon HM, Hong BK, Kim D, Kim IJ, Choi EY, Jang Y, Kim HS, Kim MS, Kwon HC

Neovascularization of the adventitial vasa vasorum with extension into the intima of atherosclerotic lesions is frequently observed, but its pathophysiological significance is still subject to debate. Recently, leptin, the product...
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A Case of Ocular Benign Lymphoid Hyperplasia Treated with Bevacizumab Injection

Oh DH, Chun YS, Kim JC

We report the first case of ocular benign lymphoid hyperplasia (BLH) treated with subconjunctival injection of bevacizumab (Avastin). A 27-year-old man presented to our clinic with conjunctival masses and limbal...
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Role of placenta growth factor in cancer and inflammation

Kim KJ, Cho CS, Kim WU

Accumulating evidences have documented that angiogenesis is closely linked to inflammation and regulators of angiogenesis play key roles in various inflammatory conditions. PlGF is an angiogenic protein belonging to the...
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The discovery of placenta growth factor and its biological activity

De Falco S

Angiogenesis is a complex biological phenomenon crucial for a correct embryonic development and for post-natal growth. In adult life, it is a tightly regulated process confined to the uterus and...
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Relationship between Pericytes and Endothelial Cells in Retinal Neovascularization: A Histological and Immunofluorescent Study of Retinal Angiogenesis

Choi SH, Chung M, Park SW, Jeon NL, Kim JH, Yu YS

PURPOSE: To evaluate the relationship between pericytes and endothelial cells in retinal neovascularization through histological and immunofluorescent studies. METHODS: C57BL/6J mice were exposed to hyperoxia from postnatal day (P) 7 to...
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The inhibitory effects of recombinant plasminogen kringle 1-3 on the neovascularization of rabbit cornea induced by angiogenin, bFGF, and VEGF

Kim JH, Kim JC, Shin SH, Chang SI, Lee HS, Chung SI

  • KMID: 1029928
  • Exp Mol Med.
  • 1999 Dec;31(4):203-209.
Angiostatin is a potent angiogenesis inhibitor that is composed of the first four kringles of plasminogen fragment. Angiostatin with one less kringle molecule (kringle 1 to 3) was...
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ICG-enhanced digital angiography and photocoagulation of choroidal neovascularization in age-related macular degeneration

Kim SH, Lee DE, Park YJ

Choroidal neovascular membranes are often poorly defined on fluorescein angiography because of fluorescein leakage or blockage of hyperfluorescence by overlying hemorrhage, lipid, turbid fluid, or pigment. Indocyanine green (ICG) is...
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Proangiogenic cells enhanced persistent and physiologic neovascularization compared with macrophages

Choi YE, Cha YR, Lee KM, Kim HJ, Yoon CH

Proangiogenic cells (PACs) display surface markers and secrete angiogenic factors similar to those used by myelomonocytic cells, but, unlike myelomonocytic cells, PACs enhance neovascularization activity in experimental ischemic diseases. This...
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Percutaneous transmyocardial revascularization induces angiogenesis: a histologic and 3-dimensional micro computed tomography study

Kwon HM, Hong BK, Jang GJ, Kim DS, Choi EY, Kim IJ, McKenna CJ, Ritman EL, Schwartz R

The purpose of this study was to visualize the spatial patterns and connection of channels created after percutaneous transmyocardial revascularization (PTMR) in normal porcine hearts, and to estimate the relative...
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Hypoxia and angiogenesis: regulation of hypoxia-inducible factors via novel binding factors

Chen L, Endler A, Shibasaki

The mechanisms that regulate angiogenesis in hypoxia or hypoxic microenvironment are modulated by several pro- and antiangiogenic factors. Hypoxia-inducible factors (HIFs) have been established as the basic and major inducers...
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Central Retinal Vein Occlusion Occurrence in an Eales Disease Patient

Nam KY, Jo YJ, Kim JY

PURPOSE: To report the occurrence of central vein occlusion in an Eales disease patient. CASE SUMMARY: A 23-year-old man presented with decreased left eye visual acuity and was diagnosed with bilateral...
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Hypoxia-inducible factor 1, hepatocellular carcinoma and angiogenesis

Kim JW

No abstract available.
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Antiangiogenesis therapy: an update after the first decade

De Falco S

Angiogenesis is a complex biological phenomenon that forms new blood vessels from the pre-existing vasculature. Aberrant angiogenesis has been implicated in a variety of diseases such as cancer, atherosclerosis, arthritis,...
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VEGF-VEGFR Signals in Health and Disease

Shibuya M

  • KMID: 2048324
  • Biomol Ther.
  • 2014 Jan;22(1):1-9.
Vascular endothelial growth factor (VEGF)-VEGF receptor (VEGFR) system has been shown to play central roles not only in physiological angiogenesis, but also in pathological angiogenesis in diseases such as cancer....
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Regulation of glucose metabolism-related genes and VEGF by HIF-1alpha and HIF-1beta, but not HIF-2alpha, in gastric cancer

Song IS, Wang AG, Yoon SY, Kim JM, Kim JH, Lee DS, Kim NS

Hypoxia-inducible factors (HIFs) are transcription factors that activate the transcription of target genes involved in crucial aspects of cancer development. This study investigated the expression of HIFs and their contribution...
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Ultrastructure and blood-iris barrier in experimental rubeosis iridis in rabbit

Ko MK, Park LW, Kim YJ, Choe JK

Iris neovascularization was produced in rabbits by hypotony following repeated aspiration of the vitreous. The hypotony was produced after 0.3 ml of vitreous fluid was aspirated using a 25-gauge needle...
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The Relationship between Prostate-specific Antigen, Invasiveness and Vascular Endothelial Growth Factor in Human Prostatic Cancer

Kim HJ, Kim DS, Yun DK, Cho JH, Kim CW, Choi JB

  • KMID: 2292316
  • Korean J Urol.
  • 2001 Jun;42(6):621-626.
PURPOSE: Vascular endothelial growth factor (VEGF) known as an angiogenic factor is a potent inducer of pathologic neovascularization. The purpose of this study is identifying the relationship between serum PSA,...
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Microvessel and Lymphatic Vessel Density and VEGFR-3 Expression of Papillary Thyroid Carcinoma with Comparative Analysis of Clinicopathological Characteristics

Cheong H, Kang H, Kim HK, Bae JY, Song DE, Cho MS, Sung SH, Han WS, Koo H

  • KMID: 1837527
  • Korean J Pathol.
  • 2010 Jun;44(3):243-251.
BACKGROUND: This study was done to see if there were correlations between anatomic and molecular parameters such as microvessel density (MVD), lymphatic vessel density (LVD), and vascular endothelial growth factor...
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