Korean J Ophthalmol.  2011 Feb;25(1):57-59. 10.3341/kjo.2011.25.1.57.

A Case of Ocular Benign Lymphoid Hyperplasia Treated with Bevacizumab Injection

Affiliations
  • 1Department of Ophthalmology, Chung-Ang University College of Medicine, Seoul, Korea. JCK50ey@kornet.net

Abstract

We report the first case of ocular benign lymphoid hyperplasia (BLH) treated with subconjunctival injection of bevacizumab (Avastin). A 27-year-old man presented to our clinic with conjunctival masses and limbal neovascularization. An incisional biopsy yielded the diagnosis of BLH. The patient was subsequently given a subconjunctival injection of bevacizumab (1.25 mg / 0.1 mL). The patient did not experience recurrence or malignant metaplasia during the one-year follow-up period. In patients with conjunctival BLH, subconjunctival injection of bevacizumab can be a useful treatment option in patients unable to undergo a surgical procedure due to limbal neovascularization.

Keyword

Bevacizumab; Conjunctival benign lymphoid hyperplasia; Subconjunctival injection

MeSH Terms

Adult
Angiogenesis Inhibitors/*administration & dosage
Antibodies, Monoclonal/*administration & dosage
Conjunctiva
Conjunctival Diseases/*drug therapy/*pathology
Humans
Hyperplasia
Injections, Intraocular
Limbus Corneae/blood supply
Lymphoid Tissue/*pathology
Lymphoproliferative Di
Male
Neovascularization, Pathologic/drug therapy

Figure

  • Fig. 1 (A) Slit lamp photograph of the patient's right eye on initial presentation. Note the size, salmon color, and elevated appearance of the hypervascular lesion. (B) Slit lamp photograph of the patient's left eye on initial presentation. Note the size, faint salmon color, and mildly protruding mass. (C,D) Slit lamp photograph of both eyes 2 months following subconjunctival injection of bevacizumab. The lesions appear to be almost completely resolved with no obvious remnants seen on the sclera or conjunctiva. (E) Slit lamp photograph of the patient's right eye after biopsy.

  • Fig. 2 Haematoxylin and eosin staining. (A) ×40 magnification of the lesion biopsied in Fig. 1A. (B) ×200 magnification of the same lesion. Note the abundance of lymphocytes and the predominance of T cells (CD3+) and B cells (CD20+), a pattern typical of benign lymphoid hyperplasia.


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