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Colonic Transit Disorder Mediated by Downregulation of Interstitial Cells of Cajal/Anoctamin-1 in Dextran Sodium Sulfate-induced Colitis Mice

Lu C, Lu H, Huang X, Liu S, Zang J, Li Y, Chen J, Xu W

  • KMID: 2449103
  • J Neurogastroenterol Motil.
  • 2019 Apr;25(2):316-331.
  • doi: 10.5056/jnm18173
BACKGROUND/AIMS: Interstitial cells of Cajal (ICC) and their special calcium-activated chloride channel, anoctamin-1 (ANO1) play pivotal roles in regulating colonic transit. This study is designed to investigate the role of...
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Potentiation of endothelium-dependent vasorelaxation of mesenteric arteries from spontaneously hypertensive rats by gemigliptin, a dipeptidyl peptidase-4 inhibitor class of anti-diabetic drug

Kim HJ, Baek EB, Kim SJ

Dipeptidyl peptidase4 (DPP4) inhibitors such as gemigliptin are anti-diabetic drugs elevating plasma concentration of incretins such as GLP-1. In addition to the DPP4 inhibition, gemigliptin might directly improve the functions...
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The Protective Effect of Melissa officinalis L. in Visceral Hypersensitivity in Rat Using 2 Models of Acid-induced Colitis and Stress-induced Irritable Bowel Syndrome: A Possible Role of Nitric Oxide Pathway

Dolatabadi F, Abdolghaffari AH, Farzaei MH, Baeeri M, Ziarani FS, Eslami M, Abdollahi , Rahimi R

  • KMID: 2417394
  • J Neurogastroenterol Motil.
  • 2018 Jul;24(3):490-501.
  • doi: 10.5056/jnm17035
BACKGROUND/AIMS: The aim of present study is to estimate the effects of Melissa officinalis L. (MO) on visceral hypersensitivity (VH), defecation pattern and biochemical factors in 2 experimental models of...
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Effects of Fengliao-Changweikang in Diarrhea-predominant Irritable Bowel Syndrome Rats and Its Mechanism Involving Colonic Motility

Jia M, Lu X, Wang Z, Zhao L, Zhang S

  • KMID: 2417393
  • J Neurogastroenterol Motil.
  • 2018 Jul;24(3):479-489.
  • doi: 10.5056/jnm17093
BACKGROUND/AIMS: This study was designed to investigate the effect of Fengliao-Changweikang (FLCWK) in diarrhea-predominant irritable bowel syndrome (IBS-D) rats and explore its underlying mechanisms. METHODS: IBS-D model rats were induced by...
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Supplementing punicalagin reduces oxidative stress markers and restores angiogenic balance in a rat model of pregnancy-induced hypertension

Wang Y, Huang M, Yang X, Yang Z, Li L, Mei J

Pre-eclampsia (PE) is a pregnancy disorder that is characterised by severe hypertension and increased risks of foetal and maternal mortality. The aetiology of PE not completely understood; however, maternal nutrition...
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Penile Erection Induced by Scoparone from Artemisia capillaris through the Nitric Oxide-Cyclic Guanosine Monophosphate Signaling Pathway

Choi BR, Kim HK, Park JK

PURPOSE: The objective of this study was to evaluate the relaxant effect of scoparone from Artemisia capillaris on rabbit penile corpus cavernosum smooth muscle (PCCSM) and to elucidate the mechanism...
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Quercetin Relaxed the Smooth Muscle of Rabbit Penile Corpus Cavernosum by Activating the NO-cGMP Signaling Pathway

Choi BR, Kim HK, Park JK

The aim of this study was to investigate the effect and action mechanism of quercetin on penile corpus cavernosum smooth muscle (PCCSM). PCCSM precontracted with phenylephrine (Phe) was treated with...
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Influence of Repeated Senna Laxative Use on Skin Barrier Function in Mice

Yokoyama S, Hiramoto K, Yamate Y, Ooi K

BACKGROUND: Senna, one of the major stimulant laxatives, is widely used for treating constipation. Chronic senna use has been reported to be associated with colonic disorders such as melanosis coli...
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Expression of Class I and Class II a/b Histone Deacetylase is Dysregulated in Hypertensive Animal Models

Kee HJ, Kim GR, Lin MQ, Choi SY, Ryu Y, Jin L, Piao ZH, Jeong MH

BACKGROUND AND OBJECTIVES: Dysregulation of histone deacetylase expression and enzymatic activity is associated with a number of diseases. It has been reported that protein levels of histone deacetylase (HDAC)1 and...
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Dexmedetomidine inhibits vasoconstriction via activation of endothelial nitric oxide synthase

Nong L, Ma J, Zhang G, Deng C, Mao S, Li H, Cui J

Despite the complex vascular effects of dexmedetomidine (DEX), its actions on human pulmonary resistance arteries remain unknown. The present study tested the hypothesis that DEX inhibits vascular tension in human...
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Pituitary Adenylate Cyclase-activating Polypeptide Inhibits Pacemaker Activity of Colonic Interstitial Cells of Cajal

Wu MJ, Kee KH, Na J, Kim SW, Bae Y, Shin DH, Choi S, Jun JY, Jeong HS, Park JS

This study aimed to investigate the effect of pituitary adenylate cyclase-activating peptide (PACAP) on the pacemaker activity of interstitial cells of Cajal (ICC) in mouse colon and to identify the...
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Effect of Nitric Oxide on the Permeability of Trabecular Meshwork Cell Monolayer

Kim HY, Kim JW

PURPOSE: To investigate the effects of nitric oxide (NO) on the permeability of cultured human trabecular meshwork cell (HTMC) monolayer. METHODS: HTMCs were cultured until confluency in the Transwell inner chamber...
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The relaxing effect of Poncirus fructus and its flavonoid content on porcine coronary artery

Yu DJ, Jun JH, Kim TJ, Suh DK, Youn DH, Kim TW

Coronary artery disease is a common occurrence in human, and causes enormous social cost. Poncirus fructus (PF), the dried immature fruits of Poncirus trifoliata Rafinesquem, is used in the treatment...
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Inhibitory Effects of Ginsenoside-Rb2 on Nicotinic Stimulation-Evoked Catecholamine Secretion

Lim HJ, Lee HY, Lim DY

The aim of the present study was to investigate whether ginsenoside-Rb2 (Rb2) can affect the secretion of catecholamines (CA) in the perfused model of the rat adrenal medulla. Rb2 (3~30...
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H2 Receptor-Mediated Relaxation of Circular Smooth Muscle in Human Gastric Corpus: the Role of Nitric Oxide (NO)

Lee SE, Kim DH, Kim YC, Han JH, Choi W, Kim CH, Jeong HW, Park SM, Yun SJ, Choi SY, Sung R, Kim YH, Yoo RY, Sun PH, Kim H, Song YJ, Xu WX, Yun HY, Lee SJ

This study was designed to examine the effects of histamine on gastric motility and its specific receptor in the circular smooth muscle of the human gastric corpus. Histamine mainly produced...
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The Relaxant Effect of Propofol on Isolated Rat Intrapulmonary Arteries

Zhang G, Cui J, Chen Y, Ma J

Propofol is a widely used anesthetic. Many studies have shown that propofol has direct effects on blood vessels, but the precise mechanism is not fully understood. Secondary intrapulmonary artery rings...
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Autonomic Nerve Regulation of Colonic Peristalsis in Guinea Pigs

Gribovskaja-Rupp I, Babygirija R, Takahashi , Ludwig K

  • KMID: 2381170
  • J Neurogastroenterol Motil.
  • 2014 Apr;20(2):185-196.
BACKGROUND/AIMS: Colonic peristalsis is mainly regulated via intrinsic neurons in guinea pigs. However, autonomic regulation of colonic motility is poorly understood. We explored a guinea pig model for the study...
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Nitric Oxide Synthase Inhibition Attenuates Cardiac Response to Hemodilution with Viscogenic Plasma Expander

Chatpun S, Cabrales P

BACKGROUND AND OBJECTIVES: Increased vascular wall shear stress by elevated plasma viscosity significantly enhances the endothelial nitric oxide synthase (eNOS) activity during an acute isovolemic hemodilution. Also the modulation of...
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Depressor action and vasorelaxation of methylene chloride fraction extracted from Rubus coreanum

Yu BS, Choi MS, Lim DY

INTRODUCTION: The present study was designed to examine whether methylene chloride (CH2Cl2) fraction extracted from Rubus coreanum affects the contractility of the isolated thoracic aortic strips and blood pressure of...
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Moderate and Deep Hypothermia Produces Hyporesposiveness to Phenylephrine in Isolated Rat Aorta

Cho JW, Lee CH, Jang JS, Kwon OC, Roh WS, Kim JE

  • KMID: 1987359
  • Korean J Thorac Cardiovasc Surg.
  • 2013 Dec;46(6):402-412.
BACKGROUND: Moderate and severe hypothermia with cardiopulmonary bypass during aortic surgery can cause some complications such as endothelial cell dysfunction or coagulation disorders. This study found out the difference of...
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