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Low-dose versus standard-dose bacille Calmette–Guérin for non-muscle-invasive bladder cancer: Systematic review and meta-analysis of randomized controlled trials

Choi SY, Ha MS, Kim JH, Chi BH, Kim JW, Chang IH, Kim TH, Myung SC

Purpose: Intravesical BCG (bacille Calmette–Guérin) instillation in patients with non-muscle-invasive bladder cancer decreases the risk for tumor recurrence and progression. After one BCG product was discontinued, a chronic global BCG...
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Peanut Sprout Extracts Cultivated with Fermented Sawdust Medium Inhibits Benign Prostatic Hyperplasia In Vitro and In Vivo

Song JH, Hwang B, Chung HJ, Moon B, Kim JW, Ko K, Kim BW, Kim WR, Kim WJ, Myung SC, Moon SK

Purpose: In this study, we tested whether the resveratrol-enriched peanut sprout extracts cultivated with fermented sawdust medium (PSEFS) could suppress benign prostatic hyperplasia (BPH) in vitro and in vivo. Materials and...
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Epigenetic Regulation of Filaggrin Gene Expression in Human Epidermal Keratinocytes

Lee J, Jang A, Seo SJ, Myung SC

BACKGROUND: Loss-of-function mutations in the filaggrin gene (FLG), which encodes an epidermal protein crucial for the formation of a functional skin barrier, have been identified as a major predisposing factor...
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Myometrial relaxation of mice via expression of two pore domain acid sensitive K⁺ (TASK-2) channels

Kyeong KS, Hong SH, Kim YC, Cho W, Myung SC, Lee MY, You RY, Kim CH, Kwon SY, Suzuki H, Park YJ, Jeong EH, Kim HS, Kim H, Lim SW, Xu WX, Lee SJ, Ji IW

Myometrial relaxation of mouse via expression of two-pore domain acid sensitive (TASK) channels was studied. In our previous report, we suggested that two-pore domain acid-sensing K⁺ channels (TASK-2) might be...
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The Internalization of Bacillus Calmette-Guerin (BCG) in Bladder Cancer Cells May be Inhibited by Human beta-defensin 3

Lim SW, Chang IH, Kim TH, Myung SC, Kim KD, Moon YT, Kim JW, Chi BH

PURPOSE: To investigate whether secretion of human beta-defensin 3 (HBD-3) is induced by bacillus Calmette-Guerin (BCG) and to determine whether HBD-3 affects BCG internalization in bladder cancer cells. MATERIALS AND METHODS:...
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Nicotine in High Concentration Causes Contraction of Isolated Strips of Rabbit Corpus Cavernosum

Nguyen HB, Lee SY, Park SH, Han JH, Lee MY, Myung SC

It is well known that cigarette smoke can cause erectile dysfunction by affecting the penile vascular system. However, the exact effects of nicotine on the corpus cavernosum remains poorly understood....
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The association of 5-alpha reductase type 2 (SRD5A2) gene polymorphisms with prostate cancer in a Korean population

Choi SY, Kim HJ, Cheong HS, Myung SC

PURPOSE: Steroid 5-alpha reductase type 2 (SRD5A2) modifies testosterone to dihydrotestosterone (DHT) in the prostate. Single-nucleotide polymorphisms (SNPs) of the SRD5A2 gene might affect DHT. We sought to understand the...
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Febrile Urinary Tract Infection After Prostate Biopsy and Quinolone Resistance

Choi JW, Kim TH, Chang IH, Kim KD, Moon YT, Myung SC, Kim JW, Kim MS, Kwon JK

PURPOSE: Complications after prostate biopsy have increased and various causes have been reported. Growing evidence of increasing quinolone resistance is of particular concern. In the current retrospective study, we evaluated...
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Predicting Recurrence and Progression of Non-Muscle-Invasive Bladder Cancer in Korean Patients: A Comparison of the EORTC and CUETO Models

Choi SY, Ryu JH, Chang IH, Kim TH, Myung SC, Moon YT, Kim KD, Kim JW

PURPOSE: This study aimed to confirm the utility of the European Organization for Research and Treatment of Cancer (EORTC) and the Spanish Urological Club for Oncological Treatment (CUETO) scoring systems...
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Pilot Study of Low-Dose Nonenhanced Computed Tomography With Iterative Reconstruction for Diagnosis of Urinary Stones

Park SH, Kim KD, Moon YT, Myung SC, Kim TH, Chang IH, Kwon JK

PURPOSE: To evaluate the efficacy of low-dose computed tomography (LDCT) for detecting urinary stones with the use of an iterative reconstruction technique for reducing radiation dose and image noise. MATERIALS AND...
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Beta-Defensin 124 Is Required for Efficient Innate Immune Responses in Prostate Epithelial RWPE-1 Cells

Kim KH, Lee J, Han JH, Myung SC

PURPOSE: The present study aimed to determine the role played by beta-defensin 124 (DEFB124) in the innate immunity of prostate epithelial RWPE-1 cells during bacterial infection. MATERIALS AND METHODS: The expression...
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Modulation of Antimicrobial Peptide Human beta-defensin-3 by Toll-like Receptor Ligands in Vaginal Epithelial Cells

Lee SY, Kim HJ, Chang IH, Han JH, Kim KD, Moon YT, Myung SC

PURPOSE: Vaginal epithelial cells have always been exposed to various pathogens. However, this has not always caused clinical infection. In addition to a previously reported protection effect of the vagina,...
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Mechanism of Relaxation Via TASK-2 Channels in Uterine Circular Muscle of Mouse

Hong SH, Sung R, Kim YC, Suzuki H, Choi W, Park YJ, Ji IW, Kim CH, Myung SC, Lee MY, Kang TM, You RY, Lee KJ, Lim SW, Yun HY, Song YJ, Xu WX, Kim HS, Lee SJ

Plasma pH can be altered during pregnancy and at labor. Membrane excitability of smooth muscle including uterine muscle is suppressed by the activation of K+ channels. Because contractility of uterine...
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Effectiveness of Flexible Ureteroscopic Stone Removal for Treating Ureteral and Ipsilateral Renal Stones: A Single-Center Experience

Lee SH, Kim TH, Myung SC, Moon YT, Kim KD, Kim JH, Kwon JK, Chang IH

  • KMID: 2316015
  • Korean J Urol.
  • 2013 Jun;54(6):377-382.
PURPOSE: The aim of this study was to evaluate the effectiveness of simultaneous flexible ureteroscopic removal of stones (URS) for ureteral and ipsilateral renal stones and to analyze the predictive...
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Relaxing Effect of Acetylcholine on Phenylephrine-Induced Contraction of Isolated Rabbit Prostate Strips Is Mediated by Neuronal Nitric Oxide Synthase

Nguyen HB, Lee SY, Park SH, Lee MY, Chang IH, Myung SC

PURPOSE: The location of acetylcholinesterase-containing nerve fibers suggests a role for acetylcholine in both contractility and secretion in the prostate gland. The colocalization of nitrergic nerves with cholinergic nerves, and...
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Improvement of andropause symptoms by dandelion and rooibos extract complex CRS-10 in aging male

Noh YH, Kim DH, Kim JY, Park J, Kim OH, Han D, Kim WY, Kim SS, Lee MY, Heo SH, Kim M, Lee WB, Jeong Y, Myung SC

  • KMID: 2313635
  • Nutr Res Pract.
  • 2012 Dec;6(6):505-512.
Many aging male suffer various andropause symptoms including loss of physical and mental activities. This study evaluated the putative alleviative effects of CRS-10 dandelion and rooibos extract complex (CRS-10) on...
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Delayed Presentation of Intravesical Bone Penetration after Pelvic Ring Fracture

Kim JH, Ha YC, Kim TH, Myung SC, Moon YT, Kim KD, Chang IH

Retrograde cystography and computed tomography (CT) are considered the gold standard for investigating bladder and pelvic bone injury. However, these methods can miss extraperitoneal bladder rupture caused by a penetrating...
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Influence of Overweight on 24-Hour Urine Chemistry Studies and Recurrent Urolithiasis in Children

Chung JD, Kim TH, Myung SC, Moon YT, Kim KD, Chang IH

  • KMID: 2315390
  • Korean J Urol.
  • 2012 Apr;53(4):268-274.
PURPOSE: We investigated the influence of overweight on 24-hour urine chemistry studies and recurrent urolithiasis (UL) in children. MATERIALS AND METHODS: A retrospective cohort study was designed to assess children who...
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A Novel Pathway Underlying the Inhibitory Effects of Melatonin on Isolated Rat Urinary Bladder Contraction

Han JH, Chang IH, Myung SC, Lee MY, Kim WY, Lee SY, Lee SY, Lee SW, Kim KD

The aim of the present study was to elucidate the direct effects of melatonin on bladder activity and to determine the mechanisms responsible for the detrusor activity of melatonin in...
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Impact of Changing Trends in Medical Therapy on Surgery for Benign Prostatic Hyperplasia Over Two Decades

Choi SY, Kim TH, Myung SC, Moon YT, Kim KD, Kim YS, Kim HR, Chang IH

PURPOSE: Following the introduction of medical therapy for benign prostatic hyperplasia (BPH), we determined the effect of the change in trends in medical therapy on the indication and outcome of...
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