- Systematic Classification of Mixed-Lineage Leukemia Fusion Partners Predicts Additional Cancer Pathways
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Marschalek R
- KMID: 2373507
- Ann Lab Med.
- 2016 Mar;36(2):85-100.
- doi: 10.3343/alm.2016.36.2.85
Chromosomal translocations of the human mixed-lineage leukemia (MLL) gene have been analyzed for more than 20 yr at the molecular level. So far, we have collected about 80 direct MLL... -
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- MLL-SEPT5 Fusion Transcript in Two de novo Acute Myeloid Leukemia Patients With t(11;22)(q23;q11)
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Wang N, Wu X, Sheng G, Ma L, Wen L, Yao H, Chen S
- KMID: 2373585
- Ann Lab Med.
- 2016 Sep;36(5):501-503.
- doi: 10.3343/alm.2016.36.5.501
No abstract available. -
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- A Rare Case of Pediatric T Lymphoblastic Leukemia With t(11;17)(q23;q21) Involving Mixed-Lineage Leukemia Gene Rearrangement
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Kim H, Lee JK, Lee JA, Hong YJ, Hong SI, Jo HS, Chang YH
- KMID: 2373500
- Ann Lab Med.
- 2016 Jan;36(1):64-66.
- doi: 10.3343/alm.2016.36.1.64
No abstract available. -
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- Acute Lymphoblastic Leukemia with Mature B-Cell Phenotype and t(9;11;11)(p22;q23;p11.2): A Case Study and Literature Review
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Kim B, Lee ST, Kim HJ, Lee SH, Yoo KH, Koo HH, Kim SH
- KMID: 1791914
- Ann Lab Med.
- 2014 Mar;34(2):166-169.
- doi: 10.3343/alm.2014.34.2.166
No abstract available. -
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- Acute Myeloid Leukemia With MLL Rearrangement and CD4+/CD56+ Expression can be Misdiagnosed as Blastic Plasmacytoid Dendritic Cell Neoplasm: Two Case Reports
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Lee JM, Kim IS, Lee JN, Park SH, Kim HH, Chang CL, Lee EY, Kim HR, Oh SH, Song SA
- KMID: 2373582
- Ann Lab Med.
- 2016 Sep;36(5):494-497.
- doi: 10.3343/alm.2016.36.5.494
No abstract available. -
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- Isolation of MLL1 Inhibitory RNA Aptamers
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Ul-Haq A, Jin ML, Jeong KW, Kim HM, Chun KH
- KMID: 2442012
- Biomol Ther.
- 2019 Feb;27(2):201-209.
- doi: 10.4062/biomolther.2018.157
Mixed lineage leukemia proteins (MLL) are the key histone lysine methyltransferases that regulate expression of diverse genes. Aberrant activation of MLL promotes leukemia as well as solid tumors in humans,... -
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- Spectra of Chromosomal Aberrations in 325 Leukemia Patients and Implications for the Development of New Molecular Detection Systems
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Choi HJ, Kim HR, Shin MG, Kook H, Kim HJ, Shin JH, Suh SP, Ryang DW
- KMID: 1094259
- J Korean Med Sci.
- 2011 Jul;26(7):886-892.
- doi: 10.3346/jkms.2011.26.7.886
This study investigated the spectrum of chromosomal abnormalities in 325 leukemia patients and developed optimal profiles of leukemic fusion genes for multiplex RT-PCR. We prospectively analyzed blood and bone marrow... -
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- Three-way Translocation of MLL/MLLT3, t(1;9;11)(p34.2;p22;q23), in a Pediatric Case of Acute Myeloid Leukemia
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Jun KR, Lee JN, Park JA, Kim HR, Shin JH, Oh SH, Lee JY, Song SA
- KMID: 1094354
- Korean J Lab Med.
- 2011 Apr;31(2):127-129.
- doi: 10.3343/kjlm.2011.31.2.127
The chromosome band 11q23 is a common target region of chromosomal translocation in different types of leukemia, including infantile leukemia and therapy-related leukemia. The target gene at 11q23, MLL, is... -
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- Clinical Utility of Fluorescence in-situ Hybridization Profile Test in Detecting Genetic Aberrations in Acute Leukemia
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Kim SR, Kim HJ, Kim SH
- KMID: 1077410
- Korean J Lab Med.
- 2009 Oct;29(5):371-378.
- doi: 10.3343/kjlm.2009.29.5.371
BACKGROUND: Cytogenetic abnormalities are one of the most reliable prognostic factors in acute leukemia. Combination of conventional chromosome analysis (CCA) and FISH provides higher sensitivity in detecting these genetic abnormalities,... -
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- A Case of Therapy-related Acute Lymphoblastic Leukemia with t(11;19)(q23;p13.3) and MLL/MLLT1 Gene Rearrangement
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Yoo BJ, Nam MH, Sung HJ, Lim CS, Lee CK, Cho YJ, Lee KN, Yoon SY
- KMID: 1096654
- Korean J Lab Med.
- 2011 Jan;31(1):13-17.
- doi: 10.3343/kjlm.2011.31.1.13
Therapy-related ALL (t-ALL) is a rare secondary leukemia that develops after chemotherapy and/or radiotherapy for primary malignancies. Chromosomal 11q23 abnormalities are the most common karyotypic alterations in t-ALL. The t(11;19)(q23;p13)... -
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- A Case of Therapy-related ALL with MLL Gene Rearrangement Following Treatment of Breast Cancer
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Cho J, Hur M, Moon HW, Yun YM, Lee CH, Lee HG
- KMID: 1781624
- Korean J Lab Med.
- 2010 Jun;30(3):255-259.
- doi: 10.3343/kjlm.2010.30.3.255
ALL with MLL gene rearrangement secondary to chemotherapy has been rarely reported. We report a case of therapy-related ALL (t-ALL) with MLL gene rearrangement in a patient who had undergone... -
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