Korean J Gastroenterol.  2016 Sep;68(3):143-147. 10.4166/kjg.2016.68.3.143.

Current Status of Translational Research on Constipation

• Lee HJ
• Park KS

• KMID: 2358716
• DOI: http://doi.org/10.4166/kjg.2016.68.3.143

Abstract

Constipation is one of the most common gastrointestinal disorders with a prevalence up to 16.5% in the general population. It is frequently multifactorial and the pathophysiologic mechanism of constipation is not fully understood. Many preclinical studies of constipation have used animal models. Translational research using these animal models is essential to the investigation of neurogenic and myogenic mechanisms of colon, and to the estimation of the clinical efficacy of new drugs. In this review, we discuss some of the current translational research projects on constipation using animal models.

Keyword

Constipation; Translational medical research; Gastrointestinal motility; Colon

MeSH Terms

Colon
Constipation*
Gastrointestinal Motility
Models, Animal
Prevalence
Translational Medical Research*
Treatment Outcome